VEGF
17 drugsVascular Endothelial Growth Factor
Predictive biomarker for patient selection in 27 indications
Understanding VEGF
What it means: VEGF is a signaling protein that promotes angiogenesis (blood vessel formation). Tumors need blood supply to grow.
Why it matters: Anti-VEGF agents (bevacizumab) and VEGFR inhibitors (sorafenib, sunitinib) starve tumors by blocking angiogenesis.
Testing: VEGF is not routinely tested for patient selection. Anti-VEGF therapies are used based on tumor type, not biomarker.
17
Approved Drugs
27
Indications
10
Companies
VEGF is a precision-medicine biomarker linked to 17 FDA-approved targeted drugs from 10 companies, spanning 27 indications including Neovascular Age-Related Macular Degeneration, Macular Edema, Retinal Vein Occlusion. Explore the targeted therapies, indications, testing methods, and companies developing VEGF drugs below.
Search VEGF Clinical Trials
Search recruiting trials on ClinicalTrials.gov
Drugs Targeting VEGF
| Drug | Company | Therapeutic Area |
|---|---|---|
| ALYMSYS | AMNEAL PHARMS | Oncology |
| AVASTIN | Roche | Oncology |
| BEOVU | Novartis | Metabolic |
| BYOOVIZ | SAMSUNG BIOEPIS CO LTD | Ophthalmology |
| CIMERLI | Novartis | Metabolic |
| EYDENZELT | CELLTRION INC | Metabolic |
| EYLEA | Regeneron | Ophthalmology |
| EYLEA HD | Regeneron | Metabolic |
| JOBEVNE | BIOCON BIOLOGICS INC | Oncology |
| LUCENTIS | Roche | Ophthalmology |
| MVASI | Amgen | Oncology |
| PAVBLU | Amgen | Metabolic |
| SUSVIMO | Roche | Metabolic |
| VABYSMO | Roche | Metabolic |
| VEGZELMA | CELLTRION INC | Oncology |
| ZALTRAP | Sanofi | Oncology |
| ZIRABEV | Pfizer | Oncology |
VEGF Indications
Neovascular Age-Related Macular Degeneration Macular Edema Retinal Vein Occlusion Diabetic Macular Edema Diabetic Retinopathy Colorectal Cancer Non-Small Cell Lung Cancer Glioblastoma Renal Cell Carcinoma Cervical Cancer Epithelial Ovarian Cancer Fallopian Tube Cancer Primary Peritoneal Cancer Hepatocellular Carcinoma Neovascular Age-related Macular Degeneration Myopic Choroidal Neovascularization Macular Edema Following Retinal Vein Occlusion Neovascular (Wet) Age-Related Macular Degeneration (AMD) Macular Edema Following Retinal Vein Occlusion (RVO) Diabetic Macular Edema (DME) Diabetic Retinopathy (DR) Retinopathy of Prematurity (ROP) Ovarian Cancer Myopic Choroidal Neovascularization (mCNV) Metastatic Colorectal Cancer Metastatic Renal Cell Carcinoma Peritoneal Cancer