Drug Targets
Biological targets being pursued by FDA-approved drugs
860
Unique Targets
59
Major Targets (10+ drugs)
2364
Company-Target Pairs
1355
Indications Covered
Most Targeted (10+ approved drugs)
Glucocorticoid receptor
41 drugs Pain, Respiratory
BAUSCH AND LOMB INC, CHEPLAPHARM, Teva +22 more
COX-2
32 drugs Immunology, Ophthalmology
Lupin, AMRING PHARMS, YUNG SHIN PHARM +24 more
COX-1
28 drugs Immunology, Ophthalmology
Lupin, AMRING PHARMS, YUNG SHIN PHARM +20 more
Estrogen Receptor
27 drugs Women's Health, Oncology
Lupin, XIROMED, RISING +19 more
Beta-2 adrenergic receptor
26 drugs Cardiovascular, Respiratory
Viatris, NEPHRON, FDC LTD +12 more
AT1 receptor
26 drugs Cardiovascular, Renal
Lupin, Novartis, MICRO LABS LTD +14 more
Mu-opioid receptor
25 drugs Pain, Respiratory
Teva, SENORES PHARMS, Fresenius Kabi +16 more
ERBB2
22 drugs Oncology
Pfizer, MERUS N.V., Boehringer Ingelheim +13 more
ACE
20 drugs Cardiovascular
Cipla, Aurobindo Pharma, WATSON LABS INC +11 more
D2 receptor
20 drugs CNS, Cardiovascular
Teva, ZYDUS PHARMS, Sun Pharma +13 more
Insulin receptor
20 drugs Metabolic
SANOFI-AVENTIS US, Eli Lilly, Sanofi +4 more
TNF
20 drugs Oncology, Immunology
Teva, Boehringer Ingelheim, Amgen +12 more
Factor Xa
19 drugs Cardiovascular
Baxter, B BRAUN, MACLEODS PHARMS LTD +8 more
DPP-4
19 drugs Metabolic
Novartis, Aurobindo Pharma, Boehringer Ingelheim +7 more
beta-adrenergic receptor
19 drugs Cardiovascular, Ophthalmology
Aurobindo Pharma, Baxter, RISING +13 more
SGLT2
18 drugs Cardiovascular, Metabolic
AstraZeneca, Johnson & Johnson, Boehringer Ingelheim +6 more
Beta-1 adrenergic receptor
17 drugs Cardiovascular, Ophthalmology
Viatris, FDC LTD, CHARTWELL MOLECULAR +8 more
opioid receptor
17 drugs Pain, Other
SPECGX LLC, Viatris, Fresenius Kabi +7 more
HMGCR
17 drugs Cardiovascular, Metabolic
CHARTWELL RX, PHARMOBEDIENT, INVAGEN PHARMS +11 more
KIT
17 drugs Oncology
Viatris, EISAI INC, BLUEPRINT MEDICINES +11 more
GLP1R
17 drugs Metabolic
SANOFI-AVENTIS US, BIOCON PHARMA, Novo Nordisk +2 more
GABA A receptor
17 drugs CNS, Other
ALMATICA, EMERGE BIOSCIENCE, LUNDBECK PHARMS LLC +10 more
EGFR
17 drugs Oncology
Johnson & Johnson, Boehringer Ingelheim, PUMA BIOTECH +11 more
VEGFA
17 drugs Metabolic, Oncology
Amgen, Roche, CELLTRION INC +7 more
RANKL
17 drugs Oncology
Fresenius Kabi, SAMSUNG BIOEPIS CO LTD, Hikma +6 more
alpha-adrenergic receptor
16 drugs Cardiovascular, Immunology
Baxter, RISING, PH HEALTH +10 more
H+/K+ ATPase
15 drugs Gastrointestinal
Dr. Reddy's, Cipla, Sun Pharma +8 more
FKBP-12
15 drugs Immunology, Oncology
STRIDES PHARMA, Dr. Reddy's, GLAND +8 more
CD20
15 drugs Oncology, CNS
Roche, GENMAB US, INC., Amgen +5 more
Dihydrofolate reductase
14 drugs Oncology
STRIDES PHARMA INTL, Hikma, Apotex +10 more
Antithrombin III
14 drugs Cardiovascular
Baxter, B BRAUN, Pfizer +4 more
Norepinephrine transporter
14 drugs Pain, CNS
SENORES PHARMS, AXSOME, STRIDES PHARMA +10 more
RET
14 drugs Oncology
EISAI INC, RIGEL PHARMS, MSN +9 more
JAK2
14 drugs Immunology, Oncology
Sun Pharma, Eli Lilly, RIGEL PHARMS +8 more
Calcium channel
13 drugs Cardiovascular
Sun Pharma, HETERO LABS, AZURITY +7 more
JAK1
13 drugs Immunology, Oncology
Pfizer, Sun Pharma, Eli Lilly +6 more
Thyroid hormone receptor
13 drugs Oncology
STEVENS J, AMNEAL, ALVOGEN +7 more
IL-23
13 drugs Immunology
AbbVie, Eli Lilly, BIO-THERA SOLUTIONS LTD +8 more
Factor IIa
12 drugs Cardiovascular
Baxter, B BRAUN, Pfizer +2 more
GnRH receptor
12 drugs Oncology, Women's Health
INVAGEN PHARMS, AbbVie, AZURITY +5 more
D2
12 drugs CNS
Johnson & Johnson, Apotex, VANDA PHARMS INC +5 more
alpha-2 adrenergic receptor
11 drugs Ophthalmology, CNS
Novartis, Merck, BIOXCEL +6 more
Carbonic anhydrase
11 drugs CNS, Rare Disease
NATCO, SUPERNUS PHARMS, TORRENT +7 more
5-HT2A receptor
11 drugs CNS
Teva, ZYDUS PHARMS, HISAMITSU +5 more
PDE5
11 drugs Urology, Cardiovascular
PHARMOBEDIENT, WATSON LABS TEVA, VIVUS LLC +7 more
RARgamma
11 drugs Immunology, Dermatology
BAUSCH, ALMIRALL, VALEANT PHARMS NORTH +4 more
ROS1
11 drugs Oncology
Roche, NUVATION, Pfizer +7 more
CD3
11 drugs Oncology, Metabolic
GENMAB US, INC., IMMUNOCORE LTD, Johnson & Johnson +5 more
PDCD1
11 drugs Oncology
INCYTE CORP, Bristol-Myers Squibb, BEIGENE +5 more
Cyclooxygenase
10 drugs Immunology, Cardiovascular
G AND W LABS INC, Hikma, MICRO LABS LTD +5 more
Calcineurin
10 drugs Immunology, Ophthalmology
STRIDES PHARMA, Teva, LEO PHARMA AS +6 more
RARalpha
10 drugs Immunology, Dermatology
BAUSCH, ALMIRALL, VALEANT PHARMS NORTH +3 more
RARbeta
10 drugs Immunology, Dermatology
BAUSCH, ALMIRALL, VALEANT PHARMS NORTH +3 more
FLT3
10 drugs Oncology
ASTELLAS, RIGEL PHARMS, MSN +6 more
Phospholipase A2
10 drugs Ophthalmology, Pain
ALEMBIC, HARROW EYE, GALDERMA LABS +5 more
VEGFR-1
10 drugs Oncology
Apotex, PF PRISM CV, Dr. Reddy's +6 more
VEGFR-2
10 drugs Oncology
Apotex, PF PRISM CV, Dr. Reddy's +6 more
VEGFR-3
10 drugs Oncology
Apotex, PF PRISM CV, Dr. Reddy's +6 more
Hyaluronan
10 drugs Oncology, CNS
Roche, Johnson & Johnson, Bristol-Myers Squibb +2 more
Other Notable Targets (3-9 drugs)
beta 2-adrenergic receptor 9
Respiratory
SERT 9
CNS
5-HT1B 9
CNS
5-HT1D 9
CNS
mTOR 9
Immunology
Thymidylate Synthase 9
Oncology
H1 receptor 9
Sleep
CSF receptor 9
Oncology
Muscarinic receptor 9
Respiratory
CD19 9
Oncology
GH receptor 9
Endocrine
Ribonucleotide reductase 8
Oncology
THROMBIN 8
Cardiovascular
Carbonic Anhydrase II 8
Cardiovascular
alpha-1 adrenergic receptor 8
Cardiovascular
5-HT1A receptor 8
CNS
P2Y12 8
Cardiovascular
VEGFR2 8
Oncology
NTRK1 8
Oncology
TRKB 8
Oncology
Dopamine transporter 8
CNS
MET 8
Oncology
CYP3A 8
Infectious Disease
Kappa-opioid receptor 8
CNS
Muscarinic acetylcholine receptor 8
Respiratory
IL-12 8
Immunology
Beta-adrenoreceptor 7
Cardiovascular
NET 7
CNS
cholinergic receptor 7
CNS
C5 7
Immunology
LCK 7
Oncology
c-KIT 7
Oncology
guanylate cyclase 7
Cardiovascular
FGFR1 7
Oncology
NK1R 7
Oncology
CFTR 7
Respiratory
Mu opioid receptor 7
CNS
ALK 7
Oncology
Androgen Receptor 7
Oncology
TYK2 7
Immunology
BRAF 7
Oncology
Topoisomerase II 7
Oncology
FLT-3 7
Respiratory
Somatostatin receptor 6
Endocrine
GABA-A receptor 6
CNS
Cholinesterase 6
CNS
5-HT3 receptor 6
Gastrointestinal
SV2A 6
CNS
Thrombin 6
Cardiovascular
Serotonin transporter 6
Pain
BCR-ABL 6
Oncology
PDGFRbeta 6
Oncology
Folylpolyglutamate Synthetase 6
Oncology
Glycinamide Ribonucleotide Formyltransferase 6
Oncology
MAP2K1 6
Oncology
PDE4 6
Immunology
VMAT2 6
CNS
FGFR2 6
Oncology
FGFR3 6
Oncology
VEGFR1 6
Oncology
+ 169 more targets