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Data updated: Jun 28, 2026

ALNYLAM PHARMS INC

Pharma
Gastroenterology Execution: Good

ALNYLAM PHARMS INC is a pharmaceutical company focused on Gastroenterology. Key products include AMVUTTRA.

2018
Since
4
Drugs
-
Trials
0
New Drugs (2yr)
Modality:
4 Small Molecules

FDA Novel Drug Designations

(2018-2022)
4 Novel 3 First-in-Class 4 Orphan 3 Breakthrough 3 Priority Review 2 Fast Track
See 4 novel approvals →
2022 AMVUTTRA (VUTRISIRAN SODIUM) Orphan · Fast Track
2020 OXLUMO (LUMASIRAN SODIUM) First-in-Class · Orphan · Breakthrough · Priority Review
2019 GIVLAARI (GIVOSIRAN SODIUM) First-in-Class · Orphan · Breakthrough · Priority Review
2018 ONPATTRO (PATISIRAN SODIUM) First-in-Class · Orphan · Breakthrough · Priority Review · Fast Track

ALNYLAM PHARMS INC at a Glance

  • Growing R&D activity with 17 trials in last 2 years
  • Fast trial execution (28 months median completion)

ALNYLAM PHARMS INC's Recent FDA Approvals

New NDA/BLA approvals for ALNYLAM PHARMS INC over the last two years — novel drugs only, excluding generics and label supplements.

No recent approvals

ALNYLAM PHARMS INC's Therapeutic Areas

ALNYLAM PHARMS INC's approved drugs and pipeline span 1 therapeutic area, led by Gastroenterology, across 0 biologic and 4 small-molecule drugs. Weighted by commercial stage — approved drugs count most, then late-stage trials.

Gastroenterology 100%
1 drugs

ALNYLAM PHARMS INC's Top Competitors

ALNYLAM PHARMS INC's closest competitors by therapeutic-area and drug-target overlap include Johnson & Johnson, Bristol-Myers Squibb, and BAUSCH. Ranked by overlap in therapeutic areas and drug targets across approved drugs and pipeline.

ALNYLAM PHARMS INC Pipeline Snapshot

Active clinical trials for ALNYLAM PHARMS INC across all therapeutic areas, from ClinicalTrials.gov.

No active pipeline data available

Phase 3 Readout Calendar Pro

4 Phase 3 trials with confidence-graded primary completion dates.

Full calendar →
Q4 2027
Nucresiran
Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy
Estimated · fresh NCT07223203
Q1 2028
Vutrisiran
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Estimated · fresh NCT06679946
Q2 2030
Nucresiran
Transthyretin Amyloidosis With Cardiomyopathy
Estimated · fresh NCT07052903
Unlock 1 more readouts with confidence-graded estimates
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Anchored on CT.gov primary completion date. Topline announcements typically precede this by 3–9 months. Confidence labels combine date type (ACTUAL/ESTIMATED) with last-update freshness.

Pro Intelligence Preview

Deep insights for investors and analysts

Revenue Insights

  • AMVUTTRA leads revenue
  • 4 key drugs tracked
View revenue breakdown →

Trial Catalysts

  • Gastroenterology pipeline focus
  • 4 Phase 3 readouts tracked
View readout calendar →

Patent Risk

  • Patent expiration timeline
  • Revenue at risk analysis
View patent timeline →

Compare Companies

  • Side-by-side pipeline analysis
  • Revenue & market share comparison
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Execution Intelligence

  • Phase 3: 10/15 completed
  • Speed: 28 months avg
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Revenue forecasts • Trial milestones • Patent risk modeling

How We Calculate These Metrics

Execution Quality Score

Measures trial completion rates weighted by phase importance. Phase 3 trials count 4x more than Phase 1 because late-stage completion is harder and more valuable.

What counts as "completed": A trial that reached its planned endpoint and reported results. Trials that were terminated early, withdrawn, or suspended are not counted as completed—these often indicate safety issues, lack of efficacy, or strategic pivots.

  • Excellent (80%+): Top-tier execution, most trials reach planned endpoints
  • Good (60-79%): Strong execution with occasional early terminations
  • Fair (40-59%): Average execution, notable rate of terminated/withdrawn trials
  • Needs Improvement (under 40%): High termination rates, execution challenges