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Data updated: Jun 28, 2026

IONIS PHARMS INC

Pharma
Pharmaceuticals Execution: Good

IONIS PHARMS INC is a pharmaceutical company with 2 FDA-approved products.

2024
Since
2
Drugs
-
Trials
2
New Drugs (2yr)
Modality:
2 Small Molecules

FDA Novel Drug Designations

(2024-2025)
2 Novel 2 First-in-Class 2 Orphan 1 Breakthrough 1 Priority Review 1 Fast Track
See 2 novel approvals →
2025 DAWNZERA (AUTOINJECTOR) (DONIDALORSEN SODIUM) First-in-Class · Orphan
2024 TRYNGOLZA (AUTOINJECTOR) (OLEZARSEN SODIUM) First-in-Class · Orphan · Breakthrough · Priority Review · Fast Track

IONIS PHARMS INC at a Glance

  • Fast trial execution (20 months median completion)

Upcoming FDA Decisions

Full Calendar →
Sep 22, 2026 — Zilganersen

IONIS PHARMS INC's Key Drugs

IONIS PHARMS INC's core commercial portfolio centers on TRYNGOLZA (AUTOINJECTOR), DAWNZERA (AUTOINJECTOR) — its most strategically important drugs approved in the last 15 years.

IONIS PHARMS INC's Recent FDA Approvals

IONIS PHARMS INC secured 2 new FDA approvals for novel drugs (NDA/BLA) in the last two years.

IONIS PHARMS INC's Therapeutic Areas

Disease areas where IONIS PHARMS INC has approved drugs and an active pipeline. Weighted by commercial stage — approved drugs count most, then late-stage trials.

No indication data

IONIS PHARMS INC Pipeline Snapshot

Active clinical trials for IONIS PHARMS INC across all therapeutic areas, from ClinicalTrials.gov.

No active pipeline data available

Phase 3 Readout Calendar Pro

8 Phase 3 trials with confidence-graded primary completion dates.

Full calendar →
Q4 2026
Donidalorsen
Hereditary Angioedema
Estimated · aging NCT05392114
Q1 2027
Olezarsen
Severe Hypertriglyceridemia
Estimated · aging NCT05681351
Q2 2027
Olezarsen
Familial Chylomicronemia Syndrome
Estimated · aging NCT05185843
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Anchored on CT.gov primary completion date. Topline announcements typically precede this by 3–9 months. Confidence labels combine date type (ACTUAL/ESTIMATED) with last-update freshness.

Pro Intelligence Preview

Deep insights for investors and analysts

Revenue Insights

  • TRYNGOLZA (AUTOINJECTOR) leads revenue
  • 2 key drugs tracked
View revenue breakdown →

Trial Catalysts

  • Active trial monitoring
  • 8 Phase 3 readouts tracked
View readout calendar →

Patent Risk

  • Patent expiration timeline
  • Revenue at risk analysis
View patent timeline →

Compare Companies

  • Side-by-side pipeline analysis
  • Revenue & market share comparison
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Execution Intelligence

  • Phase 3: 9/20 completed
  • Speed: 20 months avg
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Revenue forecasts • Trial milestones • Patent risk modeling

How We Calculate These Metrics

Execution Quality Score

Measures trial completion rates weighted by phase importance. Phase 3 trials count 4x more than Phase 1 because late-stage completion is harder and more valuable.

What counts as "completed": A trial that reached its planned endpoint and reported results. Trials that were terminated early, withdrawn, or suspended are not counted as completed—these often indicate safety issues, lack of efficacy, or strategic pivots.

  • Excellent (80%+): Top-tier execution, most trials reach planned endpoints
  • Good (60-79%): Strong execution with occasional early terminations
  • Fair (40-59%): Average execution, notable rate of terminated/withdrawn trials
  • Needs Improvement (under 40%): High termination rates, execution challenges