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Data updated: Jun 28, 2026

MADRIGAL

Pharma

MADRIGAL is a pharmaceutical company focused on Infectious Disease, Metabolic, Cardiovascular. Key products include REZDIFFRA.

2024
Since
1
Drugs
-
Trials
0
New Drugs (2yr)
Modality:
1 Small Molecules

FDA Novel Drug Designations

(2024)
1 Novel 1 First-in-Class 1 Breakthrough 1 Accelerated 1 Priority Review 1 Fast Track
See 1 novel approval →
2024 REZDIFFRA (RESMETIROM) First-in-Class · Breakthrough · Priority Review · Accelerated · Fast Track

MADRIGAL at a Glance

  • Fast trial execution (4 months median completion)

MADRIGAL's Key Drugs

MADRIGAL's core commercial portfolio centers on REZDIFFRA, spanning Infectious Disease and Metabolic — its most strategically important drugs approved in the last 15 years.

MADRIGAL's Recent FDA Approvals

New NDA/BLA approvals for MADRIGAL over the last two years — novel drugs only, excluding generics and label supplements.

No recent approvals

MADRIGAL's Therapeutic Areas

MADRIGAL's approved drugs and pipeline span 4 therapeutic areas, led by Infectious Disease and Metabolic, across 0 biologic and 1 small-molecule drug. Weighted by commercial stage — approved drugs count most, then late-stage trials.

Infectious Disease 75%
1 drugs Phase 3: 1 Phase 2: 2 Phase 1: 1
Metabolic 10%
0 drugs Phase 2: 1
Cardiovascular 10%
0 drugs Phase 2: 1
Gastroenterology 5%
0 drugs Phase 1: 1

MADRIGAL's Top Competitors

MADRIGAL's closest competitors by therapeutic-area and drug-target overlap include Merck, Baxter, and Johnson & Johnson. Ranked by overlap in therapeutic areas and drug targets across approved drugs and pipeline.

MADRIGAL Pipeline Snapshot

MADRIGAL has 7 active clinical programs from ClinicalTrials.gov — 1 Phase 3, 4 Phase 2 and 2 Phase 1.

1
Phase 3
4
Phase 2
2
Phase 1

Phase 3 Readout Calendar Pro

2 Phase 3 trials with confidence-graded primary completion dates.

Full calendar →
Q4 2026
Resmetirom
NASH
Estimated · stale NCT05500222
Q1 2028
MGL-3196
NASH - Nonalcoholic Steatohepatitis
Estimated · stale NCT03900429

Anchored on CT.gov primary completion date. Topline announcements typically precede this by 3–9 months. Confidence labels combine date type (ACTUAL/ESTIMATED) with last-update freshness.

Pro Intelligence Preview

Deep insights for investors and analysts

Revenue Insights

  • REZDIFFRA leads revenue
  • Drug-level revenue analysis

Trial Catalysts

  • Infectious Disease pipeline focus
  • 2 Phase 3 readouts tracked
View readout calendar →

Patent Risk

  • Patent expiration timeline
  • Revenue at risk analysis

Compare Companies

  • Side-by-side pipeline analysis
  • Revenue & market share comparison

Execution Intelligence

  • Phase 3: 1/4 completed
  • Speed: 4 months avg
Unlock Full Intelligence

Revenue forecasts • Trial milestones • Patent risk modeling

How We Calculate These Metrics

Execution Quality Score

Measures trial completion rates weighted by phase importance. Phase 3 trials count 4x more than Phase 1 because late-stage completion is harder and more valuable.

What counts as "completed": A trial that reached its planned endpoint and reported results. Trials that were terminated early, withdrawn, or suspended are not counted as completed—these often indicate safety issues, lack of efficacy, or strategic pivots.

  • Excellent (80%+): Top-tier execution, most trials reach planned endpoints
  • Good (60-79%): Strong execution with occasional early terminations
  • Fair (40-59%): Average execution, notable rate of terminated/withdrawn trials
  • Needs Improvement (under 40%): High termination rates, execution challenges