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Data updated: Jun 28, 2026

RHYTHM

Pharma

RHYTHM is a pharmaceutical company focused on Metabolic, Cardiovascular, Infectious Disease. Key products include IMCIVREE.

2020
Since
1
Drugs
-
Trials
0
New Drugs (2yr)
Modality:
1 Small Molecules

FDA Novel Drug Designations

(2020)
1 Novel 1 First-in-Class 1 Orphan 1 Breakthrough 1 Priority Review
See 1 novel approval →
2020 IMCIVREE (SETMELANOTIDE ACETATE) First-in-Class · Orphan · Breakthrough · Priority Review

RHYTHM at a Glance

  • Fast trial execution (21 months median completion)

RHYTHM's Key Drugs

RHYTHM's core commercial portfolio centers on IMCIVREE, spanning Metabolic and Cardiovascular — its most strategically important drugs approved in the last 15 years.

RHYTHM's Recent FDA Approvals

New NDA/BLA approvals for RHYTHM over the last two years — novel drugs only, excluding generics and label supplements.

No recent approvals

RHYTHM's Therapeutic Areas

RHYTHM's approved drugs and pipeline span 3 therapeutic areas, led by Metabolic and Cardiovascular, across 0 biologic and 1 small-molecule drug. Weighted by commercial stage — approved drugs count most, then late-stage trials.

Metabolic 69%
1 drugs Phase 3: 7 Phase 2: 8 Phase 1: 3
Cardiovascular 30%
0 drugs Phase 3: 2 Phase 2: 3 Phase 1: 9
Infectious Disease 1%
0 drugs Phase 1: 1

RHYTHM's Top Competitors

RHYTHM's closest competitors by therapeutic-area and drug-target overlap include Merck, Baxter, and Sanofi. Ranked by overlap in therapeutic areas and drug targets across approved drugs and pipeline.

RHYTHM Pipeline Snapshot

RHYTHM has 33 active clinical programs from ClinicalTrials.gov — 9 Phase 3, 11 Phase 2 and 13 Phase 1.

9
Phase 3
11
Phase 2
13
Phase 1

Phase 3 Readout Calendar Pro

3 Phase 3 trials with confidence-graded primary completion dates.

Full calendar →
Q1 2027
Setmelanotide
Hypothalamic Obesity
Estimated · fresh NCT06760546
Q4 2027
Setmelanotide
Obesity Associated With Defects in Leptin-melanocortin Pathway
Estimated · aging NCT06596135
Q4 2025
Setmelanotide
Obesity
Completed · awaiting NCT05093634

Anchored on CT.gov primary completion date. Topline announcements typically precede this by 3–9 months. Confidence labels combine date type (ACTUAL/ESTIMATED) with last-update freshness.

Pro Intelligence Preview

Deep insights for investors and analysts

Revenue Insights

  • IMCIVREE leads revenue
  • Drug-level revenue analysis

Trial Catalysts

  • Metabolic pipeline focus
  • 3 Phase 3 readouts tracked
View readout calendar →

Patent Risk

  • Patent expiration timeline
  • Revenue at risk analysis

Compare Companies

  • Side-by-side pipeline analysis
  • Revenue & market share comparison

Execution Intelligence

  • Phase 3: 5/9 completed
  • Speed: 21 months avg
Unlock Full Intelligence

Revenue forecasts • Trial milestones • Patent risk modeling

How We Calculate These Metrics

Execution Quality Score

Measures trial completion rates weighted by phase importance. Phase 3 trials count 4x more than Phase 1 because late-stage completion is harder and more valuable.

What counts as "completed": A trial that reached its planned endpoint and reported results. Trials that were terminated early, withdrawn, or suspended are not counted as completed—these often indicate safety issues, lack of efficacy, or strategic pivots.

  • Excellent (80%+): Top-tier execution, most trials reach planned endpoints
  • Good (60-79%): Strong execution with occasional early terminations
  • Fair (40-59%): Average execution, notable rate of terminated/withdrawn trials
  • Needs Improvement (under 40%): High termination rates, execution challenges