Data updated: Jun 28, 2026
Acne Clinical Trial Landscape
Acne is being studied across 384 clinical trials registered since 2008, with 39 programs currently active. The competitive pipeline includes 13 active Phase 3 trials, 13 active Phase 2 trials, and 2 active Phase 1 trials.
Top industry sponsors include AbbVie, Sanofi, Zhejiang Sunshine Mandi Pharmaceutical Co.,Ltd..
Trial activity
39 active / 384 total since 2008
Active by phase 13 Ph3 / 112 13 Ph2 / 107 2 Ph1 / 71 11 Ph4 / 94
Sponsor activity
Who is running trials now — green active, blue completed, red failed/terminated.
Sorted by active Active Done Failed
AbbVie 2 6 2
Sanofi 2 1 0
Zhejiang Sunshine Mandi Pharmaceutical Co.,Ltd. 2 1 0
Galderma R&D 1 37 0
Bausch Health Americas, Inc. 1 24 0
Sun Pharmaceutical Industries Limited 1 6 0
Integrative Skin Science and Research 1 0 0
Shanghai Huaota Biopharmaceutical Co., Ltd. 1 0 0
Sagimet Biosciences Inc. 1 0 0
Jiangxi Kvvit Pharmaceutical Co., Ltd. 1 0 0
Biofrontera Inc. 1 0 0
Eurofarma Laboratorios S.A. 1 0 0
Equipmed USA LLC 1 0 0
Stiefel, a GSK Company 0 23 0
Sun Pharmaceutical Industries, Inc. 0 17 0
How the field has grown
New-trial starts peaked in 2016 (37 registered); 2025 saw 17. The right-hand chart shows median Phase 3 enrollment by start year — the number in parentheses is that year's Phase 3 trial count (59 in total), so single-trial years (and years with no Phase 3 starts) are obvious. Both are by trial start date; the current year is partial.
New trials started by year
2016 37
2017 17
2018 23
2019 14
2020 11
2021 15
2022 10
2023 9
2024 19
2025 17
2026 10
TheraRadar.com
Median Phase 3 enrollment by start year
2016 (12) 659
2017 (10) 746
2018 (10) 597
2019 (2) 599
2020 (4) 182
2021 (2) 224
2022 (2) 411
2023 (2) 339
2024 (9) 400
2025 (4) 408
2026 (2) 609
TheraRadar.com
Full trial pipeline
Every active and completed trial across Phase 1–4, with enrollment analytics. Sortable, filterable, exportable with Pro.
NCT05995340 ACTIVE NOT RECRUITING
ELAPR002f Injectable Gel in the Treatment of Atrophic Acne Scars
AbbVie n=157
NCT07389109 ACTIVE NOT RECRUITING
A Long-term Safety and Efficacy Study of N-Acetyl-GED-0507-34-LEVO Gel 5%, in Subjects With Acne Vulgaris (GEDACNE-LT)
PPM Services S.A. n=400
NCT07384208 ACTIVE NOT RECRUITING
A Study to Assess Efficacy and Safety of N-Acetyl-GED-0507-34-LEVO Gel 5% in Patients With Acne Vulgaris (GEDACNE 2)
PPM Services S.A. n=400
NCT07384195 ACTIVE NOT RECRUITING
A Study to Assess Efficacy and Safety of N-Acetyl-GED-0507-34-LEVO Gel 5%, in Patients With Acne Vulgaris (GEDACNE-1)
PPM Services S.A. n=400
NCT07457294 NOT YET RECRUITING
1% Clascoterone Cream for the Treatment Acne Vulgaris
Zhejiang Sunshine Mandi Pharmaceutical Co.,Ltd. n=692
NCT07207369 RECRUITING
A Study to Assess the Safety and Effectiveness of ELAPR002f Injectable Gel in Adult Participants With Atrophic Acne Scars
AbbVie n=395
NCT07186413 RECRUITING
A Study to Compare the Efficacy, Safety and Pharmacokinetics of Trifarotene 50 mcg/g Cream in Chinese Subjects With Acne Vulgaris
Galderma R&D n=561
NCT06787222 ACTIVE NOT RECRUITING
Effectiveness and Safety of Zingiber Officinale Transdermal Patch for Acne Vulgaris; Study of Interleukin 1 and Skin Microbiome
Hasanuddin University n=26
NCT06403501 RECRUITING
Efficacy and Safety of Clascoterone Cream 1% in Facial Acne Vulgaris
Zhejiang Sunshine Mandi Pharmaceutical Co.,Ltd. n=692
NCT06905210 NOT YET RECRUITING
Study of New Antiandrogenic Progestogen + Low-dose Estrogen for Moderate Acne Vulgaris
Eurofarma Laboratorios S.A. n=526
NCT06447480 RECRUITING
Clinical Trial to Compare Oral Isotretinoin to Standard of Care in Moderate Acne Skin of Color Patients
Centre Hospitalier Universitaire de Nice n=420
NCT06775314 NOT YET RECRUITING
The Effectiveness and Safety of Cleanser Containing Triethyl Citrate, Pyruvic Acid, Combination Cream Containing Triethyl Citrate, Ethyl Linoleate, GT Peptide-10, Salicylic Acid 0,5%, Zinc Lactate, Hyaluronic Acid and Spot Cream Containing Triethyl Citrate, Ethyl Linoleate, GT Peptide-10, Honokiol
Dr.dr.Irma Bernadette, SpKK (K) n=102
NCT06602284 NOT YET RECRUITING
A Full Face Study to Evaluate the Efficacy of Dermapen 4™ Microneedling Device in Addition with MG-CLR Serum for Acne Treatment Over 12 Weeks.
Equipmed USA LLC n=10
NCT06248008 COMPLETED
A Study to Evaluate Safety of ASC40 Tablets in Patients With Moderate to Severe Acne Vulgaris
Ascletis Pharmaceuticals Co., Ltd. n=240
NCT05608499 TERMINATED
Duobrii Treatment of Acne Keloidalis Nuchae (AKN)
Icahn School of Medicine at Mount Sinai n=15
NCT06090721 COMPLETED
DMT310-009 Topical in the Treatment of Acne Vulgaris
Dermata Therapeutics n=520
NCT06192264 COMPLETED
A Study to Evaluate the Safety and Efficacy of ASC40 (Denifanstat) Tablets in the Treatment of Patients With Moderate to Severe Acne Vulgaris
Ascletis Pharmaceuticals Co., Ltd. n=480
NCT06242288 COMPLETED
Correlation Between Depression Scores and Serum NF-ĸB/NLRP3 Axis, Biotinidase, and HMGB After Treatment With Isotretinoin in Patients With Acne Vulgaris
Mostafa Bahaa n=40
NCT05550337 COMPLETED
Study Comparing Trifarotene Cream, 0.005% To AKLIEF ® (Trifarotene 0.005% Cream) In The Treatment Of Acne Vulgaris
Teva Pharmaceuticals USA n=807
NCT06451237 COMPLETED
Acne Remission Maintenance by Weekend Systemic Isotretinoin
Alexandria University n=60
NCT04214639 COMPLETED
Clinical Study Comparing the Efficacy and Safety of IDP-126 Gel in the Treatment of Acne Vulgaris
Bausch Health Americas, Inc. n=183
NCT04214652 COMPLETED
Clinical Study Comparing the Efficacy and Safety of IDP-126 Gel in the Treatment of Acne Vulgaris
Bausch Health Americas, Inc. n=180
NCT04960930 COMPLETED
To Evaluate the Efficacy and Safety of Minocycline Hydrochloride Foam in the Treatment of Moderate-to-severe Acne Vulgaris
Cutia Therapeutics (Shanghai) Co., Ltd n=372
NCT02667444 COMPLETED
P3 Study Comparing Once Daily SB204 and Vehicle Gel in Acne
Novan, Inc. n=1,330
NCT03334682 COMPLETED
Randomized Double-blind Study on the Benefit of Spironolactone for Treating Acne of Adult Woman.
Nantes University Hospital n=158
NCT03664752 COMPLETED
Study Comparing the Safety and Efficacy of IDP-120 Gel and IDP-120 Vehicle Gel in the Treatment of Acne Vulgaris
Bausch Health Americas, Inc. n=585
NCT03664739 COMPLETED
Study Comparing the Safety and Efficacy of IDP-120 Gel and IDP-120 Vehicle Gel in the Treatment of Acne Vulgaris
Bausch Health Americas, Inc. n=608
NCT05629468 COMPLETED
Comparing Efficacy of Azithromycin and Probiotics for Treatment of Acne Vulgaris
Pak Emirates Military Hospital n=75
NCT05573425 COMPLETED
Comparing the Efficacy of Topical Tazarotene Gel 0.1% v/s Microneedling in Atrophic Post Acne Scars
Jinnah Postgraduate Medical Centre n=202
NCT02832063 COMPLETED
Clinical Trial in Subjects With Mild to Moderate Acne Vulgaris
AOBiome LLC n=372
NCT02815280 COMPLETED
A Study to Compare the Efficacy and Safety of Topical Administration of FMX-101 for Treatment of Moderate-to-Severe Acne
Vyne Therapeutics Inc. n=495
NCT03271021 COMPLETED
A Study to Evaluate the Efficacy and Safety of Topical Administration of FMX101 in the Treatment of Moderate-to-Severe Acne Vulgaris
Vyne Therapeutics Inc. n=1,488
NCT02815267 COMPLETED
A Study to Compare the Efficacy and Safety of Topical Administration of FMX-101 for Treatment of Moderate-to-Severe Acne
Vyne Therapeutics Inc. n=466
NCT03761810 COMPLETED
A Study of S6G5T3 in the Treatment of Acne Vulgaris
Sol-Gel Technologies, Ltd. n=434
NCT03761784 COMPLETED
A Study of S6G5T-3 in the Treatment of Acne Vulgaris
Sol-Gel Technologies, Ltd. n=424
NCT03915860 COMPLETED
Participant Reported Outcomes With Use of Trifarotene 50 μg/g Cream in the Treatment of Moderate Facial and Truncal Acne Vulgaris
Galderma R&D n=47
NCT03393494 COMPLETED
Bioequivalence Study of Two Treatments in the Treatment of Acne Vulgaris on the Face
Padagis LLC n=825
NCT02515305 COMPLETED
Comparative Safety and Efficacy of Two Treatments in the Treatment of Acne Vulgaris
Padagis LLC n=890
NCT02525549 COMPLETED
Comparative Safety and Bioequivalence of Two Treatments in the Treatment of Acne Vulgaris
Padagis LLC n=903
NCT01796665 COMPLETED
A Study to Compare Clindamycin Phosphate and Benzoyl Peroxide Topical Gel 1.2%/2.5% to Acanya® Topical Gel in the Treatment of Acne Vulgaris
Padagis LLC n=1,180
NCT01138514 COMPLETED
Clinical Study Between Two Clindamycin 1%/Benzoyl Peroxide 5% Topical Gels
Padagis LLC n=1,555
NCT03073486 COMPLETED
A Study of Olumacostat Glasaretil Gel in Subjects With Acne Vulgaris
Dermira, Inc. n=744
NCT03127956 COMPLETED
A Long-term Safety Study of Olumacostat Glasaretil Gel in Subjects With Acne Vulgaris
Dermira, Inc. n=748
NCT03028363 COMPLETED
A Study of Olumacostat Glasaretil Gel in Subjects With Acne Vulgaris
Dermira, Inc. n=759
NCT03717506 COMPLETED
Bioequivalence Study of Clindamycin Phosphate Topical Lotion, 1% in Subjects With Acne Vulgaris
Balmoral Medical company n=1,236
NCT03168334 COMPLETED
A Phase 3, Vehicle-controlled Efficacy and Safety Study of IDP-123 Lotion in the Treatment of Acne Vulgaris (302)
Bausch Health Americas, Inc. n=801
NCT03168321 COMPLETED
A Phase 3, Vehicle-controlled Efficacy and Safety Study of IDP-123 Lotion in the Treatment of Acne Vulgaris (301)
Bausch Health Americas, Inc. n=813
NCT03290027 COMPLETED
A Study of the Safety and Efficacy of DFD-03 for the Treatment of Acne Vulgaris
Dr. Reddy's Laboratories Limited n=550
NCT03292640 COMPLETED
A Study of the Safety and Efficacy of DFD-03 Lotion in the Treatment of Acne Vulgaris for 12 Weeks
Dr. Reddy's Laboratories Limited n=547
NCT00883233 COMPLETED
Comparison of Four Different Regimens of Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel in Acne Vulgaris
Galderma R&D n=123
NCT01474590 COMPLETED
Efficacy & Safety Comparison of Epiduo With Doxycycline Versus Vehicle With Isotretinoin in the Treatment of Severe Acne
Galderma R&D n=266
NCT02932267 COMPLETED
Subject Reported Outcomes With Use of Adapalene 0.3% - Benzoyl Peroxide (BPO) 2.5% in Dark Skin Acne
Galderma R&D n=50
NCT00687908 COMPLETED
Adapalene-Benzoy Peroxide (BPO) Gel in the Treatment of Acne Vulgaris as a 6-month Maintenance
Galderma R&D n=243
NCT00688064 COMPLETED
Adapalene-BPO Gel Associated With Doxycycline Hyclate 100 mg in the Treatment of Severe Acne Vulgaris
Galderma R&D n=459
NCT01014689 COMPLETED
Comparison of Epiduo Associated With Lymecycline Versus Epiduo Vehicle Associated With Lymecycline in Acne Vulgaris
Galderma R&D n=378
NCT02608476 COMPLETED
A Study to Evaluate the Safety and Efficacy of CB-03-01 Cream, 1% in Subjects With Facial Acne Vulgaris (26)
Cassiopea SpA n=732
NCT02608450 COMPLETED
A Study to Evaluate the Safety and Efficacy of CB-03-01 Cream, 1% in Subjects With Facial Acne Vulgaris (25)
Cassiopea SpA n=708
NCT02682264 COMPLETED
An Open-Label, Long-Term Extension Study to Evaluate the Safety of CB-03-01 Cream, 1% in Participants With Acne Vulgaris
Cassiopea SpA n=609
NCT02005666 COMPLETED
To Compare the Efficacy and Safety of Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel of CHL Versus DUAC® Gel
Zydus Lifesciences Limited n=850
NCT03522441 COMPLETED
Bioequivalence Study of Clindamycin Gel 1% in Treatment of Acne Vulgaris
Akorn, Inc. n=1,125
NCT04329403 WITHDRAWN
Clinical Endpoint Bioequivalence Study of Adapalene Gel 0.1%
Aurobindo Pharma Ltd
NCT02651220 COMPLETED
Clinical End Point Study of Generic Adapalene and Benzoyl Peroxide Gel Versus Epiduo® Forte Gel in Treatment of Acne Vulgaris
Actavis Inc. n=1,001
NCT02267746 COMPLETED
A Study To Evaluate The Safety And Therapeutic Equivalence of Tazarotene Foam 0.1% in Subjects With Acne Vulgaris
Actavis Inc. n=893
NCT02616614 COMPLETED
Double-blind Placebo-controlled Trial of Generic Clindamycin/Benzoyl Peroxide Gel Versus Onexton Gel in Acne Vulgaris
Actavis Inc. n=862
NCT03615768 COMPLETED
A Study to Evaluate the Efficacy and Safety of Adapalene-Clindamycin Combination Gel in the Treatment of Acne Vulgaris
Lee's Pharmaceutical Limited n=1,617
NCT04015375 COMPLETED
Study Comparing Test to Aczone 7.5% and Both to a Placebo Control in the Treatment of Acne Vulgaris
Torrent Pharmaceuticals Limited n=1,150
NCT02249767 COMPLETED
Bioequivalence Study of Tretinoin Gel 0.05% to Brand Tretinoin Gel
Spear Pharmaceuticals n=574
NCT02932306 COMPLETED
Efficacy and Safety of IDP-121 and IDP-121 Vehicle Lotion in the Treatment of Acne Vulgaris
Bausch Health Americas, Inc. n=820
NCT01243450 COMPLETED
Bioequivalence Study of Generic Tretinoin 0.04% Microsphere Gel, 0.04% Retin-A Micro® and Placebo
Spear Pharmaceuticals n=958
NCT02965456 COMPLETED
Efficacy and Safety of IDP-121 and IDP-121 Vehicle Lotion in the Treatment of Acne Vulgaris
Bausch Health Americas, Inc. n=820
NCT02189629 COMPLETED
CD5789 (Trifarotene) Long Term Safety Study on Acne Vulgaris
Galderma R&D n=453
NCT02556788 COMPLETED
Double-Blind Efficacy and Safety of CD5789 (Trifarotene) 50µg/g Cream Versus Vehicle Cream in Acne Vulgaris
Galderma R&D n=1,212
NCT02566369 COMPLETED
Efficacy and Safety of CD5789 (Trifarotene) 50μg/g Cream Versus Vehicle Cream in Acne Vulgaris
Galderma R&D n=1,208
NCT01559922 COMPLETED
Use of Artefill® for Moderate to Severe Atrophic Acne Scar Correction
Suneva Medical, Inc. n=175
NCT01694433 COMPLETED
"Clinical Trial to Determine the Efficacy of Vitamin D for Acne Therapy"
University of California, Los Angeles n=66
NCT03650361 COMPLETED
Bioequivalence Study of Adapalene Gel 0.3% in Subjects With Facial Acne Vulgaris
Aleor Dermaceuticals Limited n=755
NCT01764308 TERMINATED
Effects of Omega-3 Fatty Acid Supplementation in Acne Patients
University of California, Los Angeles n=31
NCT02320149 COMPLETED
Study to Evaluate Safety & Efficacy of Sarecycline in Treatment of Acne
Almirall, S.A. n=968
NCT03178994 COMPLETED
The Study of Efficacy and Safety of 2% Ketoconazole Cream in Thai Females With Mild Degree of Post - Adolescence Acne
Chulalongkorn University n=42
NCT02413346 COMPLETED
A Multi-Center Open-Label Evaluation of the Safety of Sarecycline Tablets in the Treatment of Acne Vulgaris
Almirall, S.A. n=490
NCT02322866 COMPLETED
Randomized, Double-blind, Placebo-controlled Study to Evaluate Safety & Efficacy of Sarecycline in Treatment of Acne
Almirall, S.A. n=1,034
NCT01974323 COMPLETED
Safety and Efficacy Study of Dapsone Gel in Patients With Acne Vulgaris
Almirall, S.A. n=2,238
NCT01974141 COMPLETED
A Safety and Efficacy Study of Dapsone Gel in Patients With Acne Vulgaris
Almirall, S.A. n=2,102
NCT02886715 COMPLETED
A Study Comparing Tazarotene Cream 0.1% to TAZORAC® (Tazarotene) Cream 0.1% and Both to a Placebo Control in the Treatment of Acne Vulgaris
Fougera Pharmaceuticals Inc. n=1,110
NCT01880320 COMPLETED
Multi-center, Randomized, Double-blind Efficacy and Safety of CD0271 0.3%/CD1579 2.5 % Topical Gel in Acne Vulgaris
Galderma R&D n=503
NCT01701024 COMPLETED
Clinical Study to Test the Efficacy and Safety of ACYC to Treat Moderate to Severe Acne
Bausch Health Americas, Inc. n=498
NCT01445301 COMPLETED
Study STF115287, a Clinical Confirmation Study of GSK2585823 in the Treatment of Acne Vulgaris in Japanese Subjects
GlaxoSmithKline n=800
NCT02465632 COMPLETED
To Study Generic Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel (Glenmark Generics, Ltd) in the Treatment of Acne Vulgaris.
Glenmark Pharmaceuticals Ltd. India n=1,100
NCT00689117 COMPLETED
A Clinical Study to Evaluate the Safety and Effectiveness of an Investigational Product Called CT Gel
Stiefel, a GSK Company n=1,649
NCT00891982 COMPLETED
A Clinical Study to Evaluate the Tolerability of a Topical Antibiotic and Retinoid Used in a Combined Regimen With a BPO Wash
Stiefel, a GSK Company n=60
NCT01017120 COMPLETED
A Study to Evaluate the Safety and Efficacy of Tazarotene Foam, 0.1%, in Subjects With Common Facial Acne
Stiefel, a GSK Company n=742
NCT02073448 COMPLETED
Efficacy and Safety Study of GK530G Versus CD0271 0.1% Gel and CD1579 2.5% Gel in the Treatment of Acne Vulgaris.
Galderma R&D n=417
NCT03071549 COMPLETED
Combined Salicylic and Azaleic Acid Verus Trichloroacetic Acid 25% Peel in Treatment of Acne
Cairo University n=34
NCT01915732 COMPLETED
A Efficacy and Safety of Duac™Compared With Clindamycin Phosphate Gel in the Treatment of Mild to Moderate Acne Vulgaris
GlaxoSmithKline n=1,018
NCT02173054 COMPLETED
An Efficiency of a Moisturizer Containing Licochalcone A, L-carnitine and 1,2-decanediol With Adapalene Gel in Acne
Mahidol University n=120
NCT01017146 COMPLETED
A Study to Evaluate the Safety and Efficacy of Tazarotene Foam, 0.1%, in Subjects With Common Facial Acne - W0260-301
Stiefel, a GSK Company n=744
NCT02865005 COMPLETED
Trial of Dapsone 5.0% Gel in the Treatment of Acne Vulgaris
Seegpharm S.A. n=2,361
NCT00776919 COMPLETED
Trial of Clindamycin / Benzoyl Peroxide Gel in Subjects With Acne
Stiefel, a GSK Company n=1,315
NCT02160678 COMPLETED
Generic Tazarotene Cream, 0.1% in the Treatment of Acne Vulgaris
G & W Laboratories Inc. n=1,741
NCT01135069 COMPLETED
Bioequivalence Study of Generic Tretinoin 0.1% Microsphere Gel, 0.1% Retin-A Micro® and Placebo
Spear Pharmaceuticals n=480
NCT01400932 COMPLETED
Study STF115288, a Clinical Confirmation Study of GI148512 in the Treatment of Acne Vulgaris in Japanese Subjects
GlaxoSmithKline n=360
NCT00975143 COMPLETED
Efficacy and Safety of CIP-Isotretinoin in Patients With Severe Recalcitrant Nodular Acne
Cipher Pharmaceuticals Inc. n=925
NCT01584674 COMPLETED
A Clinical Trial Evaluating the Safety and Efficacy of the KLOX Biophotonic System in Moderate to Severe Acne
KLOX Technologies Inc. n=98
NCT00722761 COMPLETED
Safety and Efficacy Of Drospirenone and Ethinyl Estradiol vs Placebo in the Treatment of Truncal Acne
Massachusetts General Hospital n=30
NCT01788384 COMPLETED
Evaluate Therapeutic Equivalence and Safety of Two Clindamycin Phosphate and Benzoyl Peroxide Gels in Acne Vulgaris
Watson Laboratories, Inc. n=708
NCT01348321 COMPLETED
Comparison of Efficacy of Azithromycin and Levamisole Versus of Azithromycin in in the Treatment of Acne
Ahvaz Jundishapur University of Medical Sciences n=169
NCT00838812 COMPLETED
Safety and Efficacy Study of Association Between Tretinoin and Clindamycin on the Treatment of Acne Mild and Moderate
Igefarma Laboratorios S.A. n=154
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only