Data updated: Jun 28, 2026
Acute Kidney Injury Clinical Trial Landscape
Acute Kidney Injury is being studied across 220 clinical trials registered since 2008, with 72 programs currently active. The competitive pipeline includes 17 active Phase 3 trials, 31 active Phase 2 trials, and 3 active Phase 1 trials.
Trial activity
72 active / 220 total since 2008
Active by phase 17 Ph3 / 56 31 Ph2 / 81 3 Ph1 / 20 21 Ph4 / 63
Sponsor activity
Who is running trials now — green active, blue completed, red failed/terminated.
Sorted by active Active Done Failed
Ebima Clifford Okundaye 2 0 0
Arch Biopartners Inc. 1 1 0
Vantive Health LLC 1 0 1
M2RLAB SL 1 0 0
CalciMedica, Inc. 1 0 0
AstraZeneca 1 0 0
Noorik Biopharmaceuticals AG 1 0 0
Hope Biosciences LLC 1 0 0
Bilix Co.,Ltd. 1 0 0
Fresenius Medical Care North America 1 0 0
EnnovaBio 1 0 0
Kelifarma 1 0 0
River 2 Renal Corp. 1 0 0
Complexa, Inc. 0 4 0
Novartis 0 2 1
How the field has grown
New-trial starts peaked in 2025 (23 registered). The right-hand chart shows median Phase 3 enrollment by start year — the number in parentheses is that year's Phase 3 trial count (36 in total), so single-trial years (and years with no Phase 3 starts) are obvious. Both are by trial start date; the current year is partial.
New trials started by year
2016 9
2017 9
2018 8
2019 12
2020 12
2021 12
2022 12
2023 16
2024 20
2025 23
2026 20
TheraRadar.com
Median Phase 3 enrollment by start year
2016 (3) 86
2017 (3) 250
2018 (2) 156
2019 (5) 64
2020 (2) 493
2021 (2) 150
2022 (2) 286
2023 (6) 62
2024 (3) 40
2025 (6) 86
2026 (2) 360
TheraRadar.com
Full trial pipeline
Every active and completed trial across Phase 1–4, with enrollment analytics. Sortable, filterable, exportable with Pro.
NCT06337838 RECRUITING
Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial
Hamilton Health Sciences Corporation n=100
NCT07550894 NOT YET RECRUITING
Phosphate-Containing Replacement Fluid for Patients Undergoing CRRT
Sun Yat-sen University n=220
NCT05399537 RECRUITING
Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT
Vantive Health LLC n=40
NCT06531642 RECRUITING
Comparison of Early Proton Pump Inhibitor Initiation Versus Usual Care on Acute Kidney Injury in Hemorrhagic Shock Patients
The University of Texas Health Science Center, Houston n=100
NCT07161843 NOT YET RECRUITING
Use of QRX3 for Acute Tubular Necrosis Type of Renal Failure in Hospitalized Patients ( QRX-3 in ARF)
Ebima Clifford Okundaye n=500
NCT06344442 RECRUITING
Low-dose Arginine-vasopressin Supplementation on Post-transplant Acute Kidney Injury After Liver Transplantation (AVENIR Trial)
Assistance Publique - Hôpitaux de Paris n=304
NCT05084196 RECRUITING
Melatonin for Prevention of Kidney Injury
Rutgers, The State University of New Jersey n=300
NCT04982419 RECRUITING
Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
VA Office of Research and Development n=240
NCT06196853 NOT YET RECRUITING
Prevention of Cisplatin-induced Nephrotoxicity
Mahidol University n=24
NCT07156786 NOT YET RECRUITING
N-Acetylcysteine Roles in Preserving Renal Function Measured by Urinary KIM-1 (Kidney Injury Molecule-1) and Serum Creatinine on Cancer Patients With Cisplatin Based Chemotherapy: A Randomized Placebo-Controlled Trial
Fakultas Kedokteran Universitas Indonesia n=72
NCT05272878 ACTIVE NOT RECRUITING
Impact of a Treatment With Angiotensin Receptor Blocker on Outcome After Acute Kidney Injury in Patients Discharged From the ICU.
Assistance Publique - Hôpitaux de Paris n=508
NCT06866236 NOT YET RECRUITING
Use of New Drug QRX-3 for Prevention and Treatment of Chronic Kidney Disease Progression
Ebima Clifford Okundaye n=3,000
NCT04589546 ACTIVE NOT RECRUITING
Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?
Centre Hospitalier Universitaire, Amiens n=310
NCT04216927 RECRUITING
NO During CPB in Neonates to Reduce Risk of AKI
Children's Hospital Medical Center, Cincinnati n=40
NCT05339139 RECRUITING
SAfety of Regional Citrate Anticoagulation (SARCA Study)
Fresenius Medical Care North America n=50
NCT06014801 RECRUITING
Low-intensity Versus Medium-intensity Continuous Kidney Replacement Therapy for Critically Ill Patients
Jikei University School of Medicine n=400
NCT05468203 TERMINATED
PREVENTion With Sglt-2 Inhibition of Acute Kidney Injury in Intensive Care
The George Institute n=51
NCT02836899 COMPLETED
Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.
Massachusetts General Hospital n=250
NCT01636089 COMPLETED
Bicarbonates Versus Saline for Contrast Induced Acute Kidney Injury Prevention in Intensive Care Unit
University Hospital, Caen n=300
NCT01682590 TERMINATED
I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit)
Centre Hospitalier Universitaire Dijon n=500
NCT01467466 COMPLETED
Prevention of Serious Adverse Events Following Angiography
VA Office of Research and Development n=5,177
NCT02664753 TERMINATED
L-carnitine as an Adjunct Treatment for Septic Shock Patients With Acute Kidney Injury
Centre Hospitalier Universitaire de Nīmes n=254
NCT02860130 TERMINATED
Clinical Evaluation of Use of Prismocitrate 18 in Patients Undergoing Acute Continuous Renal Replacement Therapy (CRRT)
Vantive Health LLC n=34
NCT07072572 COMPLETED
Lung Point of Care Ultrasound to Guide Albumin Administration in Cirrhosis
Centro Medico Issemym n=72
NCT06000748 TERMINATED
NEPH-ROSIS (NEPHrology in CirRhOSIS) Pilot Trial: A Trial to Treat Acute Kidney Injury Among Hospitalized Cirrhosis Patients
University of California, San Francisco n=6
NCT05049590 COMPLETED
Acute Normovolemic Hemodilution in Complex Cardiac Surgery
University of California, Los Angeles n=63
NCT04411472 TERMINATED
(Revival) Study to Investigate the Efficacy and Safety of Alkaline Phosphatase in Patients With Sepsis-Associated AKI
AM-Pharma n=676
NCT03630224 TERMINATED
Plasmalyte Versus Saline in Trauma Patients
Assistance Publique - Hôpitaux de Paris n=365
NCT01077895 WITHDRAWN
The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration (CVVH) on Intra-abdominal Pressure and Kidney Function
University Hospital, Ghent
NCT02620761 TERMINATED
Fenoldopam to Prevent Renal Dysfunction in Indomethacin Treated Preterm Infants
Medical College of Wisconsin n=1
NCT02980003 COMPLETED
PrevenTion of Contrast-inducEd nephroAThy With urinE Alkalinization
G. d'Annunzio University n=240
NCT04051073 COMPLETED
Can Continuous Non-invasive Monitoring Improve Stability of Intraoperative Blood Pressure - A Feasibility Study.
University Hospital Birmingham NHS Foundation Trust n=30
NCT05375188 COMPLETED
To Evaluate if Dexmedetomidine Infusion Provides Renal Protection in Patients Undergoing Coronary Artery Bypass Graft
National Institute of Cardiovascular Diseases, Pakistan n=60
NCT02665377 COMPLETED
Prevention of Akute Kidney Injury, Hearttransplant, ANP
Sahlgrenska University Hospital n=86
NCT03403751 TERMINATED
Phase 3 Study of Reltecimod vs Placebo in Patients With Sepsis-associated Acute Kidney Injury
Atox Bio Ltd n=58
NCT04297839 SUSPENDED
Evaluation of Regional Anticoagulation With Citrate in Extended Hemodialysis
University of Sao Paulo General Hospital n=200
NCT02875873 COMPLETED
Balanced Solution Versus Saline in Intensive Care Study
Hospital do Coracao n=11,075
NCT03277677 COMPLETED
The Effect of Fluid Resuscitation With 0.9% Sodium Chloride Versus Balanced Crystalloid Solution on Renal Function of Sepsis Patients
Chulalongkorn University n=116
NCT02799368 COMPLETED
Balanced Salt Solution Versus 0.9% Saline Infusion for Prevention of Contrast-induced Acute Kidney Injury (BASIC Trial)
Seoul National University Hospital n=493
NCT01391520 WITHDRAWN
Efficacy and Safety of Deferiprone in Patients With Chronic Kidney Disease Undergoing a Cardiac Catheterization and Receiving Contrast Agent
CorMedix
NCT04019184 COMPLETED
Reduction of Occurence of Acute Kidney Injury (AKI) Through Administration of Glutamine
University Hospital Muenster n=64
NCT04259684 WITHDRAWN
Nitric Oxide During Cardiopulmonary Bypass in Neonates to Reduce Risk of Acute Kidney Injury
Children's Hospital Medical Center, Cincinnati
NCT02272725 COMPLETED
Non-steroidal Anti-inflammatory Affect on Kidneys in Endurance Distances
Stanford University n=91
NCT03331146 WITHDRAWN
Nitrite Infusion in High Risk Patients Undergoing Cardiopulmonary Bypass
University of Alabama at Birmingham
NCT01225094 COMPLETED
Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's n=606
NCT03070353 COMPLETED
Dextran, a Plasma Expander, Offers New Hope for Patients With Decompensated Liver Cirrhosis and Acute Kidney Injury
Ramathibodi Hospital n=10
NCT00557219 TERMINATED
Fenoldopam and Ketanserin for Acute Kidney Failure Prevention After Cardiac Surgery
Medical University of Gdansk n=60
NCT00286403 WITHDRAWN
Vasodilators and Anti-Oxidant Therapy in Early ATN
Southeast Renal Research Institute
NCT01786824 TERMINATED
Preventing Contrast-induced Nephropathy: Evaluating Hydration Strategies and L-carnitine Administration
Centre Hospitalier Universitaire de Nīmes n=9
NCT01239966 COMPLETED
Pulmonary And Renal Support During Acute Respiratory Distress Syndrome
Hôpital Européen Marseille n=11
NCT01197235 TERMINATED
Effect of Darbepoetin in Contrast-induced Nephropathy
Seoul National University Bundang Hospital n=80
NCT00875069 COMPLETED
Efficacy and Safety of Ethanol Lock Solution in Prevention of Catheter Related Bloodstream Infection for Patients Suffering Acute Renal Failure, and Hospitalized in Intensive Care Unit. A Multi-Center, Randomized, Versus Placebo, Double Blinded Clinical Trial
University Hospital, Clermont-Ferrand n=1,460
NCT01562925 COMPLETED
Effect of Red Wine, White Wine and Beer on Contrast-Medium Induced Acute Kidney Injury
University of Cologne n=260
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only