Data updated: Jun 28, 2026
Ankylosing Spondylitis Clinical Trial Landscape
Ankylosing Spondylitis is being studied across 137 clinical trials registered since 2008, with 22 programs currently active. The competitive pipeline includes 8 active Phase 3 trials, 8 active Phase 2 trials, and 2 active Phase 1 trials.
, LTD.
Trial activity
22 active / 137 total since 2008
Active by phase 8 Ph3 / 45 8 Ph2 / 41 2 Ph1 / 26 4 Ph4 / 25
Sponsor activity
Who is running trials now — green active, blue completed, red failed/terminated.
Sorted by active Active Done Failed
UCB Biopharma SRL 1 3 0
Suzhou Zelgen Biopharmaceuticals Co.,Ltd 1 1 0
Jiangsu vcare pharmaceutical technology co., LTD 1 1 0
Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. 1 1 0
Lynk Pharmaceuticals Co., Ltd 1 1 0
Shenzhen Huishan Biotechnology Co., Ltd. 1 0 0
XBiotech, Inc. 1 0 0
Tasly Pharmaceutical Group Co., Ltd 1 0 0
Asia Cell Therapeutics (Shanghai) Co., Ltd. 1 0 0
Bayer 0 15 0
Novartis 0 8 0
Biocad 0 4 0
Pfizer 0 2 2
Merck 0 2 1
How the field has grown
New-trial starts peaked in 2017 (13 registered); 2025 saw 7. The right-hand chart shows median Phase 3 enrollment by start year — the number in parentheses is that year's Phase 3 trial count (27 in total), so single-trial years (and years with no Phase 3 starts) are obvious. Both are by trial start date; the current year is partial.
New trials started by year
2016 11
2017 13
2018 5
2019 7
2020 5
2021 12
2022 7
2023 7
2024 5
2025 7
2026 6
TheraRadar.com
Median Phase 3 enrollment by start year
2016 (5) 199
2017 (3) 93
2018 (3) 228
2019 (4) 218
2020 (2) 506
2021 (1) 548
2022 (0) 0
2023 (4) 337
2024 (1) 180
2025 (3) 420
2026 (1) 614
TheraRadar.com
Full trial pipeline
Every active and completed trial across Phase 1–4, with enrollment analytics. Sortable, filterable, exportable with Pro.
NCT04436640 ACTIVE NOT RECRUITING
A Study to Evaluate the Long-term Safety, Tolerability and Efficacy of Bimekizumab in Subjects With Active Axial Spondyloarthritis Including Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis
UCB Biopharma SRL n=508
NCT07512960 RECRUITING
Duration of Dual Anti-Platelet Therapy in Chronic Limb Threatening Ischemia After Distal Revascularization
Fondation Hôpital Saint-Joseph n=614
NCT05861102 ACTIVE NOT RECRUITING
Efficacy and Safety Study of Jaktinib in Subjects With Active Ankylosing Spondylitis(AS)
Suzhou Zelgen Biopharmaceuticals Co.,Ltd n=265
NCT07172360 RECRUITING
Efficacy and Safety Phase III Clinical Study of VC005 Tablets in Subjects With Active Ankylosing Spondylitis.
Jiangsu vcare pharmaceutical technology co., LTD n=420
NCT07261644 RECRUITING
A Study to Evaluate the Efficacy and Safety of 608 in Adult Subjects With Active Ankylosing Spondylitis(AS)
Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. n=500
NCT07237568 RECRUITING
A Study to Evaluate Efficacy and Safety of LNK01001 in Adults With Ankylosing Spondylitis
Lynk Pharmaceuticals Co., Ltd n=352
NCT06000956 RECRUITING
A Study of Comparing Overall Improvement of Patients With Spondyloarthritis Treated With Jitongning Tablets and Placebo
Tasly Pharmaceutical Group Co., Ltd n=408
NCT06378697 COMPLETED
A Phase III Study to Evaluate the Efficacy and Safety of AK111 in Subjects With Active Ankylosing Spondylitis
Akeso n=510
NCT03928743 COMPLETED
A Study to Evaluate the Efficacy and Safety of Bimekizumab in Subjects With Active Ankylosing Spondylitis
UCB Biopharma SRL n=332
NCT07277179 COMPLETED
Evaluate the Efficacy, Safety, and Pharmacokinetic Profile and Immunogenicity of Subcutaneous Netakimab in Chinese Adult Patients With Active Ankylosing Spondylitis
SPH-BIOCAD (HK) Limited n=113
NCT02186873 COMPLETED
A Study of Golimumab in Participants With Active Ankylosing Spondylitis
Janssen Research & Development, LLC n=208
NCT03447704 COMPLETED
International Multicenter Comparative Randomized Placebo-controlled Clinical Study of Efficacy and Safety of BCD-085 in Patients With Ankylosing Spondylitis
Biocad n=228
NCT06985134 COMPLETED
Comparative Efficacy and Safety of Thalidomide and Sulfasalazine in Moderate to Severe Ankylosing Spondylitis: A Real-World Study From Bangladesh
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh n=93
NCT02469753 COMPLETED
Interest of Continuous Non-Steroidal Anti-Inflammatory Drug Treatment in Ankylosing Spondylitis Patients Treated by Anti-TNF Therapy in the Prevention of Radiographic Outcomes
University Hospital, Bordeaux n=188
NCT04156620 COMPLETED
Study to Demonstrate the Efficacy, Safety and Tolerability of an Intravenous Regimen of Secukinumab Compared to Placebo in Subjects With Active axSpA
Novartis Pharmaceuticals n=527
NCT04840485 COMPLETED
Efficacy and Safety of SHR-1314 in Patients With Active Ankylosing Spondylitis
Suzhou Suncadia Biopharmaceuticals Co., Ltd. n=548
NCT03746522 COMPLETED
Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) Participants With Moderate to Severe Obesity
Rhythm Pharmaceuticals, Inc. n=52
NCT03259074 COMPLETED
Effect of Secukinumab on Radiographic Progression in Ankylosing Spondylitis as Compared to GP2017 (Adalimumab Biosimilar)
Novartis Pharmaceuticals n=859
NCT04481139 COMPLETED
A Study to Evaluate the Efficacy and Safety of SHR0302 in Patients With Ankylosing Spondylitis
Jiangsu HengRui Medicine Co., Ltd. n=504
NCT03502616 COMPLETED
Efficacy and Safety of Tofacitinib in Subjects With Active Ankylosing Spondylitis (AS)
Pfizer n=270
NCT00762463 COMPLETED
Study Of Celecoxib Or Diclofenac For Efficacy and Safety In Chinese Patients With Ankylosing Spondylitis
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. n=240
NCT04483700 WITHDRAWN
Study to Evaluate the Efficacy and Safety of Filgotinib in Participants With Active Ankylosing Spondylitis Who Are Naive to Biologic Disease-Modifying Antirheumatic Drug Therapy
Gilead Sciences
NCT04483687 WITHDRAWN
Study to Evaluate the Efficacy and Safety of Filgotinib in Participants With Active Ankylosing Spondylitis Who Have an Inadequate Response to Biologic Disease-Modifying Antirheumatic Drug Therapy
Gilead Sciences
NCT02505542 COMPLETED
Study to Evaluate Maintenance of Sustained Remission of axSpA With CZP Compared to Placebo
UCB BIOSCIENCES GmbH n=736
NCT04345458 COMPLETED
Safety and Efficacy Study of Prefilled Liquid Etanercept(Yisaipu) for Active Ankylosing Spondylitis
Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. n=640
NCT04174131 COMPLETED
Restylane + Lidocaine and Restylane Lyft for the Treatment of Nasolabial Folds
Erevna Innovations Inc. n=10
NCT03357471 COMPLETED
Study to Test the Safe and Effective Use of an e-Device for the Self-injection of Certolizumab Pegol Solution by Subjects With Moderate to Severe Active Rheumatoid Arthritis, Active Ankylosing Spondylitis, Active Psoriatic Arthritis, or Moderately to Severely Active Crohn's Disease
UCB Biopharma S.P.R.L. n=70
NCT04135508 COMPLETED
A Phase III Study Evaluate the Efficacy and Safety of BAT1406 and Humira
Bio-Thera Solutions n=554
NCT02750592 COMPLETED
Study of Efficacy and Safety of Secukinumab in Japanese Patients With Active Ankylosing Spondylitis
Novartis Pharmaceuticals n=30
NCT02685904 TERMINATED
A Multicentre Study to Evaluate the Efficacy and Safety of ENIA11 in Patients With Ankylosing Spondylitis
Mycenax Biotech Inc. n=10
NCT02893254 COMPLETED
Efficacy and Safety of IBI303 in Adult Patients With Active Ankylosing Spondylitis
Innovent Biologics (Suzhou) Co. Ltd. n=438
NCT02762812 COMPLETED
Comparative Clinical Trial to Evaluate Efficacy and Safety of BCD-055 and Remicade® in Patients With Ankylosing Spondylitis
Biocad n=199
NCT02163330 TERMINATED
Normal Pressure Hydrocephalus Treatment by Acetazolamide
Rabin Medical Center n=2
NCT00844805 COMPLETED
Infliximab for Treatment of Axial Spondyloarthritis (P05336 AM1)
Merck Sharp & Dohme LLC n=158
NCT01358175 COMPLETED
16 Week Efficacy and 2 Year Long Term Safety and Efficacy of Secukinumab in Patients With Active Ankylosing Spondylitis
Novartis Pharmaceuticals n=371
NCT01694264 TERMINATED
Study of Anti-Viral Prophylaxis for HBsAg(+) or HBcAb(+)/HBsAb(-) Patients Starting Anti-TNFα
Seoul National University Hospital n=43
NCT01586650 COMPLETED
Effects of Aerobic Training in Patients With Ankylosing Spondylitis
Federal University of São Paulo n=70
NCT01091675 COMPLETED
Assessment of the Response to Etoricoxib in Patients With Ankylosing Spondylitis and Inadequate Response to ≥2 NSAIDs
Spanish Foundation of Rheumatology n=58
NCT01671852 WITHDRAWN
Intranasal Mometasone in Children With Obstructive Sleep Apnea Due to Adenotonsillar Hypertrophy
Children's & Women's Health Centre of British Columbia
NCT01248793 COMPLETED
Study of the Safety and Efficacy of Golimumab in Chinese Patients With Ankylosing Spondylitis
Centocor, Inc. n=213
NCT00667355 COMPLETED
A Study of Adalimumab in Japanese Subjects With Active Ankylosing Spondylitis
Abbott n=41
NCT01114880 COMPLETED
Efficacy and Safety of Adalimumab in Adult Chinese Subjects With Active Ankylosing Spondylitis
Abbott n=344
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only