Data updated: Jun 28, 2026
Constipation Clinical Trial Landscape
Constipation is being studied across 294 clinical trials registered since 2008, with 38 programs currently active. The competitive pipeline includes 12 active Phase 3 trials, 16 active Phase 2 trials, and 1 active Phase 1 trials.
Top industry sponsors include Ardelyx, Shionogi, Eli Lilly.
Trial activity
38 active / 294 total since 2008
Active by phase 12 Ph3 / 110 16 Ph2 / 99 1 Ph1 / 21 9 Ph4 / 64
Sponsor activity
Who is running trials now — green active, blue completed, red failed/terminated.
Sorted by active Active Done Failed
Ardelyx 4 5 0
Shionogi 1 4 0
Eli Lilly 1 0 0
HK inno.N Corporation 1 0 0
Bausch Health Americas, Inc. 0 17 1
AstraZeneca 0 10 1
Takeda 0 7 2
Forest Laboratories 0 8 1
Braintree Laboratories 0 8 0
Ironwood Pharmaceuticals, Inc. 0 6 1
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) 0 2 4
Ferring Pharmaceuticals 0 3 3
AbbVie 0 5 0
Glycyx Therapeutics 0 5 0
Astellas 0 4 0
How the field has grown
New-trial starts peaked in 2016 (23 registered); 2025 saw 12. The right-hand chart shows median Phase 3 enrollment by start year — the number in parentheses is that year's Phase 3 trial count (34 in total), so single-trial years (and years with no Phase 3 starts) are obvious. Both are by trial start date; the current year is partial.
New trials started by year
2016 23
2017 11
2018 11
2019 6
2020 10
2021 1
2022 10
2023 8
2024 10
2025 12
2026 5
TheraRadar.com
Median Phase 3 enrollment by start year
2016 (10) 208
2017 (1) 552
2018 (4) 76
2019 (2) 410
2020 (3) 100
2021 (1) 175
2022 (5) 160
2023 (1) 150
2024 (1) 300
2025 (4) 43
2026 (2) 385
TheraRadar.com
Full trial pipeline
Every active and completed trial across Phase 1–4, with enrollment analytics. Sortable, filterable, exportable with Pro.
NCT05905926 ENROLLING BY INVITATION
Safety Study of Tenapanor for the Treatment of Pediatric Patients (6 to Less Than 18 Years Old) With IBS-C
Ardelyx n=150
NCT06413368 RECRUITING
Maralixibat in Patients With Cystic Fibrosis and Constipation
Children's Hospital Los Angeles n=20
NCT07522255 NOT YET RECRUITING
Rifaximin Treatment in Bloating Predominant Functional Bowel Disorders
Mahidol University n=78
NCT06810167 RECRUITING
Assessing Tenapanor as a Treatment of CF-related Constipation.
Massachusetts General Hospital n=25
NCT07382167 RECRUITING
A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults
Ardelyx n=692
NCT07277907 RECRUITING
Efficacy and Safety of Lubiprostone in the Treatment of Slow Transit Constipation
Third Military Medical University n=346
NCT05643534 ACTIVE NOT RECRUITING
Study to Assess Safety and Efficacy of Tenapanor for Treatment of IBS-C in Pediatric Patients 12 to Less Than 18 Years
Ardelyx n=180
NCT05519683 RECRUITING
Home Transcutaneous Electrical Acustimulation (TEA)
University of Michigan n=160
NCT04547816 RECRUITING
Efficacy of Conservative Treatment of Functional Defecatory Disorders in Females With Pelvic Organ Prolapse
Federal State Budgetary Scientific Institution "Federal Research Centre of Nutrition, Biotechnology n=100
NCT06836024 NOT YET RECRUITING
A Trial of Actazin Versus PEG 3350 for Maintenance Therapy in Children With Constipation
Hamilton Health Sciences Corporation n=60
NCT06740422 NOT YET RECRUITING
Xuanhuang Runtong Tablet in the Treatment of Constipation (Yin-deficiency Type)
Beijing Hospital of Traditional Chinese Medicine n=300
NCT06351995 ACTIVE NOT RECRUITING
Neostigmine and Glycopyrrolate by Iontophoresis
James J. Peters Veterans Affairs Medical Center n=6
NCT04166058 COMPLETED
Long-term Safety of Linaclotide in Pediatric Participants With FC or IBS-C
AbbVie n=381
NCT05652205 COMPLETED
A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation
AbbVie n=123
NCT04026113 COMPLETED
Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC)
AbbVie n=438
NCT02809105 COMPLETED
A Study of Oral Dosing of ASP0456 in Patients With Chronic Constipation
Astellas Pharma Inc n=186
NCT02316899 COMPLETED
Phase III Study to Evaluate the Efficacy and Safety of ASP0456 in Patients With Constipation Predominant Irritable Bowel Syndrome
Astellas Pharma Inc n=500
NCT05151328 COMPLETED
Efficacy and Safety of Plecanatide Comparing With Placebo in the Treatment of Functional Constipation
Shandong Luoxin Pharmaceutical Group Stock Co., Ltd. n=648
NCT04759833 TERMINATED
A Study of Prucalopride For Functional Constipation in Children and Teenagers
Takeda n=175
NCT02822508 COMPLETED
A Safety and Efficacy Evaluation of BLI801 Laxative in Adults Experiencing Non-Idiopathic Constipation
Braintree Laboratories n=434
NCT05341180 COMPLETED
Efficacy of Polyethylene Glycol vs Lactulose With Isabgol in Acute Fissure-in-Ano: PEGASIS Trial
All India Institute of Medical Sciences, Bhubaneswar n=144
NCT04433390 COMPLETED
Effect of Naloxegol on Postoperative Ileus in Patients Undergoing Cardiac Surgery
CMC Ambroise Paré n=305
NCT01117051 TERMINATED
Prucalopride Effects on Subjects With Chronic Non-cancer Pain Suffering From Opioid Induced Constipation
Shire n=174
NCT01147926 COMPLETED
Evaluation of Prucalopride in Male Subjects With Chronic Constipation.
Shire n=374
NCT02705378 WITHDRAWN
The Effect of Naloxegol on Refractory Constipation in the Intensive Care Unit
Massachusetts General Hospital
NCT03573908 COMPLETED
A Trial of Linaclotide 290 μg in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
Ironwood Pharmaceuticals, Inc. n=614
NCT02727751 COMPLETED
A Long-Term Safety Study of Tenapanor for the Treatment of IBS-C
Ardelyx n=312
NCT02481947 COMPLETED
A Safety and Efficacy Evaluation of BLI400 Laxative in Constipated Adults
Braintree Laboratories n=459
NCT02819297 COMPLETED
BLI400-302: A Safety and Efficacy Evaluation of BLI400 Laxative in Constipated Adults
Braintree Laboratories n=1,020
NCT02042183 COMPLETED
Lubiprostone in Children With Functional Constipation
Sucampo Pharma Americas, LLC n=606
NCT02819310 COMPLETED
An Open Label Study of Chronic Use of BLI400 Laxative in Constipated Adults
Braintree Laboratories n=330
NCT04451096 COMPLETED
Probiotics-prebiotic Fiber Therapy in Parkinson's Disease Patients With Constipation
National University of Malaysia n=48
NCT02766777 COMPLETED
Evaluation of the Safety of Lubiprostone in Pediatric Participants Aged ≥ 6 Years to < 18 Years With Functional Constipation
Sucampo Pharma Americas, LLC n=87
NCT02686138 COMPLETED
A 26-Week Study to Evaluate the Efficacy and Safety of Tenapanor in IBS-C
Ardelyx n=593
NCT02621892 COMPLETED
A 12-Week Study With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Tenapanor for the Treatment of IBS-C
Ardelyx n=606
NCT01923428 COMPLETED
The Efficacy of AZD1722 in Constipation Predominant Irritable Bowel Syndrome (IBS-C)
Ardelyx n=356
NCT02138136 COMPLETED
Lubiprostone for Children With Constipation
Sucampo Pharma Americas, LLC n=419
NCT03097861 COMPLETED
Evaluation of the Bioequivalence of Sprinkle and Capsule Formulations of Lubiprostone, as Compared to Placebo
Sucampo Pharma Americas, LLC n=552
NCT00936884 COMPLETED
Study Evaluating the Efficacy and Safety of Subcutaneous Methylnaltrexone (MOA-728) for the Treatment of Opioid-Induced-Constipation
Bausch Health Americas, Inc. n=50
NCT01982240 COMPLETED
12-Week Study of Plecanatide for CIC (The CIC3 Study)
Bausch Health Americas, Inc. n=1,394
NCT01993875 COMPLETED
Pharmacodynamic, Pharmacokinetic, and Tolerability Study of a Liquid Form of Lubiprostone in Adult Subjects With Chronic Idiopathic Constipation
Mallinckrodt n=164
NCT00804141 COMPLETED
Study Evaluating Long-Term Safety of MOA-728 in Participants With Opioid-Induced Constipation
Bausch Health Americas, Inc. n=1,040
NCT01186770 COMPLETED
A Study of Oral Methylnaltrexone (MNTX) for the Treatment of Opioid-Induced Constipation (OIC) in Participants With Chronic, Non-Malignant Pain
Bausch Health Americas, Inc. n=804
NCT01919697 COMPLETED
Open-label Extension (OLE) Study of Plecanatide for Chronic Idiopathic Constipation (CIC)
Bausch Health Americas, Inc. n=2,370
NCT02387359 COMPLETED
The Plecanatide Irritable Bowel Syndrome With Constipation Study (IBS-C)
Bausch Health Americas, Inc. n=1,054
NCT02493452 COMPLETED
Second Plecanatide Study In Irritable Bowel Syndrome With Constipation (IBS-C)
Bausch Health Americas, Inc. n=1,135
NCT01429987 COMPLETED
The Plecanatide Chronic Idiopathic Constipation (CIC) Study
Bausch Health Americas, Inc. n=951
NCT02122471 COMPLETED
12-Week Study of Plecanatide for CIC (The National CIC3 Study)
Bausch Health Americas, Inc. n=1,410
NCT03885973 COMPLETED
Lactobacillus Plantarum IS 10560 Supplementation in Women With Functional Constipation
Fakultas Kedokteran Universitas Indonesia n=76
NCT00765999 COMPLETED
An Open-Label, Long-Term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation
Forest Laboratories n=1,559
NCT03829358 COMPLETED
The Role of Probiotics in Improving Quality of Life in Women With Functional Constipation
Fakultas Kedokteran Universitas Indonesia n=76
NCT01901341 TERMINATED
The Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) n=44
NCT01901302 TERMINATED
Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) n=61
NCT01696643 TERMINATED
Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) n=1,407
NCT01901328 TERMINATED
Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) n=49
NCT01438567 COMPLETED
A Study to Demonstrate Improvement in Symptoms of Constipation in Subjects That Require Around-the-clock Opioid Pain Killer Therapy
Mundipharma Research GmbH & Co KG n=270
NCT02194972 COMPLETED
Clinical Effects of Soluble Dietary Fiber Supplementation
Nanjing PLA General Hospital n=80
NCT02651155 COMPLETED
Lubiprostone for the Treatment of Chronic Idiopathic Constipation
Takeda n=204
NCT00730171 COMPLETED
An Open-label, Long-term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation
Ironwood Pharmaceuticals, Inc. n=1,743
NCT02961556 COMPLETED
General Clinical Study of AJG555 in Pediatric Patients With Chronic Constipation
EA Pharma Co., Ltd. n=39
NCT02291679 COMPLETED
Trial of Linaclotide in Patients With Chronic Idiopathic Constipation
Ironwood Pharmaceuticals, Inc. n=1,223
NCT01469819 COMPLETED
Lubiprostone Effect on Gastrointestinal Tract Transit Times Measured by Smartpill in Patients With Chronic Constipation
Texas Tech University Health Sciences Center, El Paso n=37
NCT01447849 COMPLETED
Lubiprostone and Mucus Secretion in Patients With Chronic Constipation
Texas Tech University Health Sciences Center, El Paso n=40
NCT01993940 COMPLETED
Efficacy and Safety of Naldemedine in Treating Opioid-induced Constipation
Shionogi n=553
NCT01965158 COMPLETED
Efficacy and Safety of Naldemedine in the Treatment of Opioid-induced Constipation
Shionogi n=547
NCT01116206 COMPLETED
An Efficacy and Safety Study of Prucalopride in Participants With Chronic Constipation
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. n=507
NCT01151878 COMPLETED
Glucomannan for Childhood Functional Constipation.
Medical University of Warsaw n=92
NCT01395524 COMPLETED
A 12-week Extension of the Phase III Study (D3820C00004) to Assess the Effect and Safety of NKTR-118 in Patients With Non-cancer-related Pain and Opioid-induced Constipation
AstraZeneca n=302
NCT01880424 COMPLETED
A Phase 3, International, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Efficacy and Safety Trial of Linaclotide Administered Orally for 12 Weeks to Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
AstraZeneca n=1,722
NCT02138851 COMPLETED
The Effects of a Ficus Carica in Subjects With Functional Constipation
Chonbuk National University Hospital n=80
NCT01895543 COMPLETED
Safety and Tolerability Extension Trial for Patients With Chronic Idiopathic Constipation
Ferring Pharmaceuticals n=411
NCT01642914 COMPLETED
Safety and Efficacy of Linaclotide in Patients With Chronic Constipation and Prominent Abdominal Bloating
Forest Laboratories n=487
NCT01411501 COMPLETED
Efficacy and Safety of Acupuncture for Functional Constipation
Guang'anmen Hospital of China Academy of Chinese Medical Sciences n=684
NCT01827592 TERMINATED
26 Week Efficacy and Safety Trial for Patients With Chronic Idiopathic Constipation
Ferring Pharmaceuticals n=376
NCT01833065 TERMINATED
Efficacy and Safety Trial of Elobixibat in Patients With Chronic Idiopathic Constipation
Ferring Pharmaceuticals n=314
NCT01014559 TERMINATED
Efficacy of Oxycodone/Naloxone(OXN), Versus Oxycodone (OXY), for the Reduction of Intensity of Opioid-induced Constipation in Pain Patients
Mundipharma SAS n=225
NCT02292459 WITHDRAWN
Efficacy and Safety of Polyethylene Glycol 3350 (PEG 3350) for Relief of Constipation (MK-8114-005)
Bayer
NCT01323790 COMPLETED
Assessment of Efficacy and Safety in Patients With Non-cancer-related Pain and Opioid-induced Constipation
AstraZeneca n=700
NCT01309841 COMPLETED
Assessment of Efficacy and Safety in Patients With Non-cancer-related Pain and Opioid-induced Constipation
AstraZeneca n=652
NCT01384292 TERMINATED
Assessment of Efficacy and Safety in Relieving Opioid-induced Constipation in Patients With Cancer-related Pain
AstraZeneca n=14
NCT02073006 COMPLETED
A Study to Evaluate the Effects of a Natural Supplement in Adults With Chronic Functional Constipation
Atlantia Food Clinical Trials n=70
NCT01607060 COMPLETED
Impact of Laxative Therapy With Lactulose in the Evolution of Organ Dysfunction in Critically Ill Patients.
Federal University of São Paulo n=88
NCT01837940 COMPLETED
Efficacy of a Dietary Supplementation With Lactobacillus Reuteri for Digestive Health in an Elderly Population
Örebro University, Sweden n=290
NCT01336205 COMPLETED
Assessment of Long-term Safety in Patients With Non-cancer-related Pain and Opioid-induced Constipation
AstraZeneca n=844
NCT00990951 SUSPENDED
Study of Efficacy of Association of Senna Alexandrina Mill and Associations on Functional Intestinal Constipation
Marjan Industria e Comercio ltda n=80
NCT01674530 COMPLETED
Evaluation of Clinical Equivalence Between Two Lubiprostone Products in the Treatment of Chronic Idiopathic Constipation
Dr. Reddy's Laboratories Limited n=909
NCT00938717 COMPLETED
Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
Ironwood Pharmaceuticals, Inc. n=805
NCT01870700 COMPLETED
Lactobacillus Reuteri in Adult With Functional Chronic Constipation
Catholic University, Italy n=40
NCT00742872 TERMINATED
Randomized Trial of Mosapride Versus Placebo in the Treatment of Constipation-Predominant Irritable Bowel Syndrome
American University of Beirut Medical Center n=41
NCT00994851 COMPLETED
Evaluation of Cassia Fistula + Senna Alexandrina Miller in the Chronic Functional Constipation Treatment.
Sanofi n=96
NCT00765882 COMPLETED
Phase III, Randomized, Double-Blind, Placebo-Controlled, Trial of Linaclotide Administered to Patients With Chronic Constipation
Forest Laboratories n=633
NCT00948818 COMPLETED
Trial of Linaclotide Administered to Patients With Irritable Bowel Syndrome With Constipation
Forest Laboratories n=803
NCT00730015 COMPLETED
Trial of Linaclotide in Patients With Chronic Constipation
Ironwood Pharmaceuticals, Inc. n=643
NCT00931853 COMPLETED
Efficacy and Tolerability of Cassia Fistula Plus Senna Alexandrina Miller (Sugar Free) in the Chronic Functional Constipation (CFC).
Sanofi n=117
NCT01474499 COMPLETED
A Trial of Docusate Sodium and Sorbitol Rectal Solution for the in Patients With Constipation
Ferring Pharmaceuticals n=300
NCT01251822 COMPLETED
Comparator Study of PEG 3350 Versus Prucalopride in Females With Chronic Constipation
Norgine n=240
NCT01372423 COMPLETED
Evaluation of Clinical Equivalence Between Two Lubiprostone Products
Anchen Pharmaceuticals, Inc n=808
NCT00992576 COMPLETED
Optimisation of Hydromorphone - Naloxone Ratio for the Treatment of Pain
Mundipharma Research GmbH & Co KG n=600
NCT00571896 COMPLETED
The Use of SennaS for Prevention of Post-operative Constipation After Urogynecologic Surgery
Hartford Hospital n=72
NCT01161784 COMPLETED
The Effects of a Probiotic Fermented Milk on Functional Constipation in Adults
IMU University, Malaysia n=100
NCT00745147 COMPLETED
Comparison of TCM and Laxatives for Adults With Chronic Constipation
National Taiwan University Hospital n=93
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only