NCT06321302 ACTIVE NOT RECRUITING A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diabetic Retinopathy
Boehringer Ingelheim
NCT04678895 RECRUITING Low-Dose Naltrexone for the Treatment of Painful Diabetic Neuropathy
Dartmouth-Hitchcock Medical Center
NCT07553429 RECRUITING A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated
Boehringer Ingelheim
NCT07271186 RECRUITING Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease
Regeneron Pharmaceuticals
NCT04547439 RECRUITING Sleep, Diabetic Retinopathy and Melatonin
University of Illinois at Chicago
NCT05759468 RECRUITING NAD Augmentation in Diabetes Kidney Disease
Brigham and Women's Hospital
NCT07457632 NOT YET RECRUITING Integrative Liver-Targeted Therapy for Diabetic Macular Edema: Combining Tauroursodeoxycholate and Traditional Chinese Medicine.
University of Alabama at Birmingham
NCT06600412 RECRUITING The Evaluation of the Drug R3R01 for the Excretion of Protein in the Urine in Patients With Diabetic Kidney Disease.
River 3 Renal Corp.
NCT06969807 RECRUITING Safety and Efficacy of Mesenchymal Stromal Cells (Amimestrocel ) in Diabetic Kidney Disease
Chinese PLA General Hospital
NCT06664502 ACTIVE NOT RECRUITING A 2-part Study Consisting of a Multiple Ascending Dose Safety Study in Participants With Macular Edema Following Branch Retinal Vein Occlusion and a Dose-finding Safety and Preliminary Efficacy Study in Participants With Either Diabetic Macular Edema or Neovascular Age-related Macular Degeneration
EyeBiotech Ltd.
NCT07459829 NOT YET RECRUITING Study of CU06-1004 in Patients With Daibetic Macular Edema
Curacle Co., Ltd.
NCT07458061 RECRUITING Kamuvudine-9 (K9) in Diabetic Macular Edema
Dr. Bryan Strelow
NCT07383701 NOT YET RECRUITING Lactiplantibacillus Plantarum 299v Probiotic Supplementation in Patients With Diabetic Macular Edema
Massachusetts Eye and Ear Infirmary
NCT07354477 RECRUITING Single-site Pilot Study Evaluating the Effect of QLS-111 Ophthalmic Solution on Posterior Perfusion and Vessel Dilation
Qlaris Bio, Inc.
NCT07396155 RECRUITING Safety and Efficacy of Allogeneic Umbilical Cord Mesenchymal Stem Cell Therapy in Diabetic Nephropathy Patients: A Clinical Trial
PT. Prodia Stem Cell Indonesia
NCT07022418 RECRUITING Formoterol in Diabetes
Medical University of South Carolina
NCT07240987 NOT YET RECRUITING Mesenchymal Stem Cells for Chronic Kidney Diseases
The First Affiliated Hospital of Air Force Medicial University
NCT05727891 ACTIVE NOT RECRUITING Evaluation of Tonabersat for DME
Jaeb Center for Health Research
NCT05623111 RECRUITING Perineural Injections of Incobotulinumtoxin-A for Diabetic Neuropathic Pain of the Lower Extremities
Rigshospitalet, Denmark
NCT06866158 ACTIVE NOT RECRUITING Autologous Dendritic Cell as Adjunct Therapy for Diabetic Kidney Disease
PT. JES Kasih Nusantara Sejahterah
NCT07259928 RECRUITING Safety and Proof of Concept Study of ANXV (Annexin A5) in Patients With Diabetic Retinopathy or Retinal Vein Occlusion
Annexin Pharmaceuticals AB
NCT04116398 ACTIVE NOT RECRUITING Pilot and Phase 2 Study of the Efficacy of a Treatment Protocol With Dexamethasone Implant Loading Dose in Patients With Diabetic Macular Edema (LOADEX)
Hospices Civils de Lyon
NCT07236645 NOT YET RECRUITING Efficacy and Safety of Ginkgo Biloba Extract EGb761® in Patients With Diabetic Retinopathy
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
NCT03161652 RECRUITING Effect of Levosulpiride on Retinal Alterations in Patients With Diabetic Retinopathy and Diabetic Macular Edema
Carmen Clapp
NCT06116916 ACTIVE NOT RECRUITING Study to Assess the Efficacy & Safety of KHK4951 in Patients With Diabetic Macular Edema
Kyowa Kirin Co., Ltd.
NCT07199777 NOT YET RECRUITING A Phase 2a Study to Evaluate the Safety, Tolerability, and Efficacy of SNP318 in DME Patients
SciNeuro
NCT06813274 NOT YET RECRUITING Multicenter RCT of Eye-Brain Imaging in Diabetes Neurovascular Coupling
Hejiang Ye
NCT05930561 ACTIVE NOT RECRUITING 4D-150 in Patients With Diabetic Macular Edema
4D Molecular Therapeutics
NCT04567550 ACTIVE NOT RECRUITING RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy (DR) With and Without Center Involved-Diabetic Macular Edema (CI-DME)
AbbVie
NCT05822609 RECRUITING Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes
University of Washington
NCT04573920 ACTIVE NOT RECRUITING Atrasentan in Patients With Proteinuric Glomerular Diseases
Novartis Pharmaceuticals
NCT07036796 RECRUITING Effect of Melatonin in Patients With Diabetic Peripheral Neuropathy
Ain Shams University
NCT05507892 ACTIVE NOT RECRUITING Renal Mechanism of SGLT2 Inhibition
University of Colorado, Denver
NCT06962098 RECRUITING Efficacy and Safety Study of Isuzinaxib in Subjects With DKD
Aptabio Therapeutics, Inc.
NCT06845163 RECRUITING Randomized Clinical Trial to Evaluate the Effect of Dapagliflozin in Patients With Diabetic Macular Edema
Alexandria University
NCT06770933 RECRUITING A Study to Evaluate the Efficacy and Safety of Orally Administered VX-01
Vantage Biosciences Ltd
NCT05387837 ACTIVE NOT RECRUITING Safety, Tolerability and PK of Subcutaneous D-4517.2 in Subjects With Wet AMD or DME
Ashvattha Therapeutics, Inc.
NCT06787482 RECRUITING Evaluating a New Peptide Therapy for Retinal Diseases: AMD, Diabetic Retinopathy, and Dystrophies
Ace Cells Lab Limited
NCT06942520 RECRUITING Phase 2 Trial of RGX-314 in Adults With Center Involved - Diabetic Macular Edema (CI - DME)
Sierra Eye Associates
NCT06708260 RECRUITING A Phase 2 Study to Evaluate the Efficacy and Safety of ENN0403 in Subjects with DME
EnnovaBio
NCT06536491 RECRUITING EC-104 Intravitreal Implant for the Treatment of Diabetic Macular Edema
Eclipse Life Sciences, Inc.
NCT05687890 ACTIVE NOT RECRUITING A Study to Evaluate the Efficacy and Safety of SC0062 in the Treatment of Chronic Kidney Disease
Biocity Biopharmaceutics Co., Ltd.
NCT06492876 RECRUITING Gene Therapy for DME
Frontera Therapeutics
NCT05393284 ACTIVE NOT RECRUITING Phase 2 Spectra Study to Evaluate the Safety and Efficacy of OPL-0401 in Patients With Diabetic Retinopathy
Valo Health, Inc.
NCT05151731 COMPLETED A Study to Investigate Vamikibart (RO7200220) in Diabetic Macular Edema
Hoffmann-La Roche
NCT06850922 COMPLETED A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO7446603 Administered Alone or in Combination With Aflibercept or Faricimab in Participants With Diabetic Macular Edema
Genentech, Inc.
NCT07501052 COMPLETED Study of the SCD411 Prefilled Syringe for Treating Adults With Wet Age-Related Macular Degeneration, Retinal Vein Occlusion, Diabetic Macular Edema, or Diabetic Retinopathy
Sam Chun Dang Pharm. Co. Ltd.
NCT05681884 COMPLETED Safety and Efficacy of Faricimab in Patients With NPDR
Greater Houston Retina Research
NCT05476276 COMPLETED EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy
James P. Rathmell, MD
NCT05480228 COMPLETED EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA
James P. Rathmell, MD
NCT07444892 COMPLETED Levodopa for Diabetic Retinopathy
Emory University
NCT06599684 COMPLETED Study of INV-102 Ophthalmic Solution in Adults With Diabetic Macular Edema Associated With Non-proliferative Diabetic Retinopathy
Invirsa, Inc.
NCT03620773 COMPLETED Impact of Metabolic Surgery on Pancreatic, Renal and Cardiovascular Health in Youth With Type 2 Diabetes
University of Colorado, Denver
NCT03685253 TERMINATED Nicotinamide Riboside for Diabetic Neuropathy
University of Maryland, Baltimore
NCT06415214 COMPLETED Efficacy and Safety of HRS-7535 Tablets in Adults With Diabetic Kidney Disease in Type 2 Diabetes
Shandong Suncadia Medicine Co., Ltd.
NCT04552600 COMPLETED Study to Evaluate Clinical Efficacy and Safety of Nuvastatic™ - C5OSEW5050ESA in Diabetic Retinopathy.
Natureceuticals Sdn Bhd
NCT03006081 COMPLETED The Efficacy of Intravitreal Aflibercept Injection in Improvement of Retinal Nonperfusion in Diabetic Retinopathy
Asan Medical Center
NCT04087941 WITHDRAWN Efficacy and Safety of VM202 in Painful Diabetic Peripheral Neuropathy -The HOPES Trial
Brigham and Women's Hospital
NCT06489340 WITHDRAWN P2a Open Label Study to Evaluate 2-HPβCD in Subjects With Diabetic Kidney Disease
ZyVersa Therapeutics, Inc.
NCT05919693 COMPLETED A 2-part Study Consisting of Multiple Ascending Dose (MAD) Safety Study, and a Dose-finding Masked Study to Assess the Safety and Efficacy of Intravitreal (IVT) EYE103 in Patients With Diabetic Macular Edema (DME) or Neovascular Age-related Macular Degeneration (NVAMD)
EyeBiotech Ltd.
NCT05151744 COMPLETED A Study to Investigate Vamikibart (RO7200220) in Combination With Ranibizumab in Diabetic Macular Edema
Hoffmann-La Roche
NCT05301751 COMPLETED A Single Ascending Dose Cohort Study of AG-73305 in DME Patients
Allgenesis Biotherapeutics Inc.
NCT05712720 COMPLETED Study to Evaluate the Efficacy and Safety of RZ402 in Diabetic Macular Edema (DME)
Rezolute
NCT06948292 COMPLETED Role of QRX-3 in Chronic Kidney Disease Patients in Outpatients Clinics
Ebima Clifford Okundaye
NCT05697809 COMPLETED Suprachoroidal Sustained-Release OXU-001 Compared to Intravitreal Ozurdex® in the Treatment of Diabetic Macular Edema
Oxular Limited
NCT07117942 COMPLETED FDGL Dose-Finding Study for Diabetic Neuropathy
Helwan University
NCT05383209 COMPLETED Study of EYP-1901 in Patients With Nonproliferative Diabetic Retinopathy (NPDR)
EyePoint Pharmaceuticals, Inc.
NCT05514548 COMPLETED Phase 2 Study of INV-202 in Patients With Diabetic Kidney Disease
Inversago Pharma Inc.
NCT06011798 COMPLETED Assess the Efficacy and Safety of Repeat Intravitreal Injections of Foselutoclax (UBX1325) in Patients With DME (ASPIRE)
Unity Biotechnology, Inc.
NCT06181227 TERMINATED A Phase 2 Study of Intravitreal AVD-104 in Diabetic Macular Edema
Aviceda Therapeutics, Inc.
NCT04418427 COMPLETED ADVM-022 Intravitreal Gene Therapy for DME
Adverum Biotechnologies, Inc.
NCT07039318 COMPLETED Mesenchymal Stem Cell Therapy in Diabetic Kidney Disease-A Double-blind, Placebo-controlled, Randomized Clinical Trial
National Institute of Blood and Marrow Transplant (NIBMT), Pakistan
NCT01068041 COMPLETED Effects of PH3 in Diabetic Nephropathy
PhytoHealth Corporation
NCT00811889 COMPLETED Trial to Determine the Effects of Bardoxolone Methyl on eGFR in Patients With Type 2 Diabetes and Chronic Kidney Disease
Biogen
NCT00664027 COMPLETED Phase IIa Trial to Determine the Effects of Bardoxolone Methyl on Renal Function in Patients With Diabetic Nephropathy
Biogen
NCT04565756 COMPLETED A Study to Evaluate the Safety and Tolerability of EXN407
Exonate Limited
NCT03397264 COMPLETED A Dose Ranging Study of OPT-302 With Aflibercept for Persistent Diabetic Macular Edema
Opthea Limited
NCT06003751 COMPLETED A Study of PER-001 in Participants With Diabetic Retinopathy
Perfuse Therapeutics, Inc.
NCT04722991 COMPLETED Non-proliferative Diabetic Retinopathy Treated With Runcaciguat
Bayer
NCT01331005 COMPLETED NSAID Phase II for Non-central Involved Diabetic Macular Edema (DME)
Jaeb Center for Health Research
NCT06099184 COMPLETED Study of EYP-1901 in Patients With Diabetic Macular Edema (DME)
EyePoint Pharmaceuticals, Inc.
NCT01447147 COMPLETED A Study to Evaluate the Safety and Efficacy of CCX140-B in Subjects With Diabetic Nephropathy
Amgen
NCT01440257 COMPLETED A Study to Evaluate the Effect of CCX140-B on Urinary Albumin Excretion in Subjects With Type 2 Diabetes and Albuminuria
Amgen
NCT05593575 COMPLETED Efficacy and Safety of SPH3127 Tablets on Treating the Diabetic Kidney Disease
Shanghai Pharmaceuticals Holding Co., Ltd
NCT02585622 TERMINATED NEPHSTROM for Diabetic Kidney Disease
Mario Negri Institute for Pharmacological Research
NCT04919499 COMPLETED A Study of BI 765128 in Patients With an Eye Condition Called Diabetic Macular Ischemia Who Have Received Laser Treatment
Boehringer Ingelheim
NCT05512962 COMPLETED Oxulumis® Suprachoroidal Microcatherization of Triesence® in Diabetic Macular Edema
Oxular Limited
NCT02302079 COMPLETED A Study to Evaluate ASP8232 in Reducing Central Retinal Thickness in Subjects With Diabetic Macular Edema (DME)
Astellas Pharma Europe B.V.
NCT04265261 COMPLETED A Study to Investigate the Efficacy and Safety of RG7774 in Patients With Diabetes Mellitus Type 1 or Type 2 With Treatment-Naive Diabetic Retinopathy
Hoffmann-La Roche
NCT05897372 TERMINATED Feasibility of Aggressive Albuminuria Reduction in Biopsy-Proven Diabetic Nephropathy - a Pilot Study
Iain Bressendorff
NCT03755934 TERMINATED Efficacy and Safety of MEDI7352 in Participants With Painful Diabetic Neuropathy
AstraZeneca
NCT06131918 COMPLETED Assessment of Antioxidant Therapy on Oxidative Stress Biomarkers in Type 2 Diabetic Patients With Neuropathy
Khyber Medical University Peshawar
NCT05409235 COMPLETED Nesvategrast (OTT166) in Diabetic Retinopathy (DR)
OcuTerra Therapeutics, Inc.
NCT04170543 COMPLETED A Phase 2b Diabetic Kidney Disease Study
AstraZeneca
NCT03927690 COMPLETED Multiple Dose Safety and Efficacy of LKA651 in Patients With Diabetic Macular Edema
Novartis Pharmaceuticals
NCT04424290 COMPLETED HORNBILL: A Study to Test Different Doses of BI 764524 in Patients Who Have Had Laser Treatment for a Type of Diabetic Eye Disease Called Diabetic Retinopathy With Diabetic Macular Ischemia
Boehringer Ingelheim
NCT04857996 COMPLETED Safety, Tolerability and Evidence of Activity Study of UBX1325 in Patients With Diabetic Macular Edema (BEHOLD)
Unity Biotechnology, Inc.
NCT05573100 COMPLETED The Study of CU06-1004 in Patients With Diabetic Macular Edema (DME)
Curacle Co., Ltd.
NCT04772105 COMPLETED Clinical Study of the Safety and Efficacy of BAT5906 Injection
Bio-Thera Solutions
NCT04697758 TERMINATED Safety and Bioactivity of AXT107 in Subjects With Diabetic Macular Edema
AsclepiX Therapeutics, Inc.
NCT01478737 COMPLETED Intravitreal Ozurdex After Pars Plana Vitrectomy for Proliferative Diabetic Retinopathy
Anders Kvanta
NCT00711490 COMPLETED Sirolimus to Treat Diabetic Macular Edema
National Eye Institute (NEI)
NCT04782115 COMPLETED Evaluation of RC28-E Injection in Diabetic Macular Edema
RemeGen Co., Ltd.
NCT04419467 COMPLETED Vascular Endothelial Growth Factor-B (VEGF-B) Blockade With the Monoclonal Antibody CSL346 in Subjects With Diabetic Kidney Disease
CSL Behring
NCT04597918 COMPLETED A Study to Investigate Aqueous Humor and Multimodal Imaging Biomarkers in Treatment-Naïve Participants With Diabetic Macular Edema Treated With Faricimab
Hoffmann-La Roche
NCT04527107 COMPLETED A Study to Evaluate THR-149 Treatment for Diabetic Macular Oedema
Oxurion
NCT05977465 COMPLETED Empagliflozin in Treatment of Peripheral Diabetic Neuropathy
Tanta University
NCT05038020 TERMINATED A Study to Evaluate the Efficacy of Oral AKST4290 in Participants With Moderately Severe to Severe Diabetic Retinopathy (CAPRI)
Alkahest, Inc.
NCT04786340 COMPLETED A 12-Week Study of Topical Pirenzepine or Placebo in Type 2 Diabetic Patients (T2DM) With Painful Peripheral Neuropathy
WinSanTor, Inc
NCT05063734 TERMINATED A Study to Evaluate THR-687 Treatment for Diabetic Macular Oedema.
Oxurion
NCT02511067 WITHDRAWN Ranibizumab for Edema of the mAcula in Diabetes: Protocol 4 With Tocilizumab: The READ-4 Study
University of Nebraska
NCT05961007 SUSPENDED Evaluation of IBI302 Injection in nAMD or DME
Innovent Biologics (Suzhou) Co. Ltd.
NCT03197870 COMPLETED The TIME-2b Study: A Study of AKB-9778 (Razuprotafib), a Novel Tie 2 Activator, in Patients With Non-Proliferative Diabetic Retinopathy (NPDR)
EyePoint Pharmaceuticals, Inc.
NCT02914613 COMPLETED Safety and Exploratory Efficacy Study of SF0166 for the Treatment of Diabetic Macular Edema (DME)
OcuTerra Therapeutics, Inc.
NCT00606138 COMPLETED Ranibizumab for Treatment of Persistent Diabetic Neovascularization Assessed by Wide-Field Imaging
Rush University Medical Center
NCT04692688 COMPLETED Study of the Safety and Efficacy of APX3330 in Diabetic Retinopathy
Ocuphire Pharma, Inc.
NCT04026165 COMPLETED Study to Evaluate the Efficacy and Safety of Selonsertib in Participants With Moderate to Advanced Diabetic Kidney Disease
Gilead Sciences
NCT04005287 COMPLETED A 24-Week Study of Topical Pirenzepine or Placebo in Type 2 Diabetic Patients (T2DM) With Peripheral Neuropathy
WinSanTor, Inc
NCT01610557 COMPLETED Ranibizumab and Bevacizumab for Diabetic Macular Edema
National Eye Institute (NEI)
NCT01821677 COMPLETED A Safety and Efficacy Study of Oral Danazol (a Previously Approved Drug) in the Treatment of Diabetic Macular Edema.
Ampio Pharmaceuticals. Inc.
NCT01476501 COMPLETED Vitamin D Supplementation in Diabetic Nephropathy
University of Alberta
NCT03449199 COMPLETED Phase 2 Study of TMX-049 in Subjects With Type 2 Diabetes and Albuminuria
Teijin America, Inc.
NCT03804879 COMPLETED Safety, Tolerability and Efficacy of Nidufexor in Patients With Diabetic Nephropathy
Novartis Pharmaceuticals
NCT03627715 COMPLETED Safety and Effectiveness of Propagermanium in Diabetic Kidney Disease Participants Receiving Irbesartan
Dimerix Bioscience Pty Ltd
NCT05343156 COMPLETED Efficacy and Safety of Dexamethasone Nanoparticles Eye Drops in Diabetic Macular Edema
Oculis
NCT04588948 WITHDRAWN A Pharmacokinetic stuDy of intRavitreal Aflibercept Injection in Vitrectomized and Non-vitrectomized Eyes With Diabetic Macular Edema
Stanford University
NCT04071977 COMPLETED Combined Antioxidant Therapy on Oxidative Stress in Aqueous and Vitreous Humor of Diabetic Retinopathy Patients
University of Guadalajara
NCT03412006 COMPLETED A Double-blind Study to Investigate Efficacy, Safety and Tolerability of BAY1142524 in Patients With Type II Diabetes and a Clinical Diagnosis of Diabetic Kidney Disease
Bayer
NCT03878277 COMPLETED Evaluation of Coffee Therapy for Improvement of Renal Oxygenation
University of Colorado, Denver
NCT04085341 COMPLETED A Depot Formulation of Sunitinib Malate (GB-102) in Subjects With Diabetic Macular Edema and Retinal Vein Occlusion
Graybug Vision
NCT03297294 TERMINATED Safety and Efficacy of EMA401 in Patients With Painful Diabetic Neuropathy (PDN)
Novartis Pharmaceuticals
NCT02448446 COMPLETED The Effect of Intravitreal Ranibizumab on Visual Acuity and Hard Exudate Resolution in the Treatment of Diabetic Macular Edema With Center Involved Edema and Lipid Exudates
South Coast Retina Center; Carson, McBeath, Boswell, Inc.
NCT03238963 COMPLETED A Study That Tests BI 1467335 in Patients With Diabetic Eye Disease (Diabetic Retinopathy). It Looks at the Way BI 1467335 is Taken up, the Effects it Has, and How Well it is Tolerated.
Boehringer Ingelheim
NCT03749642 COMPLETED Trazodone/Gabapentin Fixed Dose Combination Products in Painful Diabetic Neuropathy
Aziende Chimiche Riunite Angelini Francesco S.p.A
NCT02863354 COMPLETED Intravitreal Aflibercept for Retinal Non-Perfusion in Proliferative Diabetic Retinopathy
Charles C Wykoff, PhD, MD
NCT03531294 COMPLETED Intravitreal Aflibercept as Indicated by Real-Time Objective Imaging to Achieve Diabetic Retinopathy Improvement
Greater Houston Retina Research
NCT04661917 WITHDRAWN A Trial to Learn More About How BAY2327949 Works and How Safe it is in Patients Whose Kidneys Are Damaged Due to High Blood Sugar Levels or High Blood Pressures, and With a Further Disease of the Heart or the Blood Vessels.
Bayer
NCT02753400 COMPLETED Study to Evaluate Effects of Emixustat Hydrochloride in Subjects With Proliferative Diabetic Retinopathy
Kubota Vision Inc.
NCT03126786 COMPLETED Suprachoroidal CLS-TA With Intravitreal Aflibercept Versus Aflibercept Alone in Subject With Diabetic Macular Edema
Clearside Biomedical, Inc.
NCT02949024 COMPLETED Suprachoroidal Injection of CLS-TA Alone or With Aflibercept in Subjects With Diabetic Macular Edema
Clearside Biomedical, Inc.
NCT01571232 COMPLETED Ozurdex for Treatment of Recalcitrant Diabetic Macular Edema
Retina Macula Institute
NCT04082000 TERMINATED Phase 2a Study Examining the Safety and Efficacy of BOL-DP-o-04 for Treating Diabetic Neuropathy
Breath of Life International Pharma Ltd
NCT03466099 COMPLETED Study of the Intravitreal Plasma Kallikrein Inhibitor, KVD001, in Subjects With Center-involving Diabetic Macular Edema (ciDME)
KalVista Pharmaceuticals, Ltd.
NCT03920878 WITHDRAWN Cataract DME - Peri vs. Intraop
Emory University
NCT02681809 TERMINATED A Study to Evaluate the Efficacy and Safety of Ocriplasmin in Inducing Total PVD in Subjects With NPDR
ThromboGenics
NCT01934556 COMPLETED A Safety and Efficacy Trial of a Treat and Extend Protocol Using Ranibizumab With and Without Laser Photocoagulation for Diabetic Macular Edema
Palmetto Retina Center, LLC
NCT01982435 COMPLETED Safety and Efficacy of Ranibizumab for Diabetic Macular Edema
Justis Ehlers
NCT02699450 COMPLETED A Study of Faricimab (RO6867461) in Participants With Center-Involving Diabetic Macular Edema
Hoffmann-La Roche
NCT01441102 COMPLETED Dextromethorphan for Diabetic Macular Edema
National Eye Institute (NEI)
NCT03732287 COMPLETED Cooling Anesthesia for Intravitreal Injection
Recens Medical, Inc.
NCT01988246 COMPLETED Prevention of Macular Edema In Patients With Diabetic Retinopathy Undergoing Cataract Surgery
Rishi Singh
NCT01822925 COMPLETED Study of DA-9801 to Treat Diabetic Neuropathy
NeuroBo Pharmaceuticals Inc.
NCT02151695 COMPLETED Safety and Efficacy of Aflibercept in Proliferative Diabetic Retinopathy.
Poitiers University Hospital
NCT02571972 COMPLETED Dorzolamide-timolol Drops With Injections to Treat AMD, RVO or DME.
Wills Eye
NCT01601236 COMPLETED Acthar for Treatment of Proteinuria in Diabetic Nephropathy Patients
Mallinckrodt
NCT03629210 WITHDRAWN Combination OZURDEX® & EyLea® vs. OZURDEX® Monotherapy in IncompLete-Responders wIth Diabetic Macular Edema
Pradeepa Yoganathan
NCT02177786 COMPLETED Efficacy, Safety, and Tolerability of Selonsertib (GS-4997) in Participants With Diabetic Kidney Disease
Gilead Sciences
NCT03902925 COMPLETED Pain During Pars Plana Vitrectomy With Sub-tenon Anesthesia
University of Sao Paulo
NCT01056315 TERMINATED A Trial in Painful Diabetic Peripheral Neuropathy With GRT3983Y
Grünenthal GmbH
NCT03608839 COMPLETED Effect of Dexamethasone on Reduction of Macular Thickness in Diabetic Patients, a Randomized Clinical Trial
Universidade Federal de Pernambuco
NCT01683409 COMPLETED A Study to Test Safety and Efficacy of Baricitinib in Participants With Diabetic Kidney Disease
Eli Lilly and Company
NCT02221453 COMPLETED Cytokine Levels in Patients With Persistent Diabetic Macular Edema Treated With Triamcinolone Acetonide
Unity Health Toronto
NCT01774981 COMPLETED Study of LY3016859 in Participants With Diabetic Nephropathy
Eli Lilly and Company
NCT01113801 TERMINATED A Study in Participants With Diabetic Kidney Disease
Eli Lilly and Company
NCT03078101 COMPLETED EMPRA (EMPagliflozin and RAs in Kidney Disease)
Medical University of Vienna
NCT03499223 COMPLETED A Study to Evaluate THR-317 and Ranibizumab Combination Treatment for Diabetic Macular Oedema (DME)
Oxurion
NCT01752985 TERMINATED Study to Evaluate the Effects of BMS-813160 on Protein Loss in the Urine of Subjects With Type 2 Diabetes and Diabetic Kidney Disease
Bristol-Myers Squibb
NCT03533478 COMPLETED Alzer® and Diamel® to Prevent Severe Diabetes Macular Edema
Catalysis SL
NCT01476449 COMPLETED Dosing Study of Ranibizumab for Diabetic Retinal and Macular Edema
Retina Vitreous Associates of Florida
NCT02363621 COMPLETED Evaluation of Inflammation and Pain Post Injection of Ranibizumab vs Aflibercept in Patients With DME
Arshad Khanani
NCT00799227 COMPLETED Safety and Efficacy of a New Treatment in Vitrectomized Subjects With Diabetic Macular Edema
Allergan
NCT03384524 WITHDRAWN Evaluation of Bromocriptine, Metoprolol and Tamsulosin in Eyes With Non-Central DME
Andrew Moshfeghi, MD, MBA
NCT01594281 COMPLETED Multicenter 12 Months Clinical Study to Evaluate Efficacy and Safety of Ranibizumab Alone or in Combination With Laser Photocoagulation vs. Laser Photocoagulation Alone in Proliferative Diabetic Retinopathy (PRIDE)
Novartis Pharmaceuticals
NCT00913393 TERMINATED Study of FibroGen (FG)-3019 in Subjects With Type 2 Diabetes Mellitus and Kidney Disease on ACEi and/or ARB Therapy
Kyntra Bio
NCT02345057 COMPLETED A Study to Evaluate Efficacy and Safety of CS-3150 in Japanese Type 2 Diabetic Subjects With Microalbuminuria
Daiichi Sankyo
NCT00672451 TERMINATED Rhubarb and Angiotensin Converting Enzyme Inhibitor
Wake Forest University
NCT02348918 COMPLETED Phase 2 Randomized Clinical Trial of Luminate® as Compared to Avastin® in the Treatment of Diabetic Macular Edema
Allegro Ophthalmics, LLC
NCT00917553 COMPLETED Evaluation of Effect of Doxycycline Verses Placebo on Retinal Function and Diabetic Retinopathy
Thomas Gardner
NCT01787669 COMPLETED Trial of Switching Between Intravitreal Bevacizumab (Avastin®)& Intravitreal Dexamethasone (Ozurdex™) for Persistent Diabetic Macular Oedema
University of Sydney
NCT01564459 COMPLETED Study to Evaluate MK-6096 in the Treatment of Painful Diabetic Neuropathy (PDN) in Adults (MK-6096-021)
Merck Sharp & Dohme LLC
NCT00511875 COMPLETED Evaluation of Doxycycline Verses Placebo for the Treatment of Severe Nonproliferative or Mild or Moderate Proliferative Diabetic Retinopathy
Thomas Gardner
NCT01265563 COMPLETED N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
VA Office of Research and Development
NCT01552408 COMPLETED Efficacy & Safety Trial of Intravitreal Injections Combined With PRP for CSME Secondary to Diabetes Mellitus (DAVE)
David M. Brown, M.D.
NCT02712008 COMPLETED Anti-vasculaR Endothelial Growth Factor plUs Anti-angiopoietin 2 in Fixed comBination therapY: Evaluation for the Treatment of Diabetic Macular Edema
Regeneron Pharmaceuticals
NCT03202979 COMPLETED Trazodone in Painful Diabetic Neuropathy
Aziende Chimiche Riunite Angelini Francesco S.p.A
NCT01945866 COMPLETED Phase II Combination Steroid and Anti-VEGF for Persistent DME
Jaeb Center for Health Research
NCT00920764 COMPLETED A Study of Atrasentan on Reducing Albuminuria in Type 2 Diabetic Nephropathy Treated With Renin-Angiotensin System Inhibitors
AbbVie (prior sponsor, Abbott)
NCT03071068 COMPLETED A Study to Evaluate the Safety and Efficacy of THR-317 for the Treatment of Diabetic Macular Oedema (DME)
ThromboGenics
NCT02435862 COMPLETED A Clinical Trial Designed to Evaluate the Safety and Efficacy Study of Luminate® in Inducing PVD (Posterior Vitreous Detachment) in Non-Proliferative Diabetic Retinopathy
Allegro Ophthalmics, LLC
NCT02068027 COMPLETED Study of Clonidine Hydrochloride Topical Gel, 0.1% in the Treatment of Pain Associated With Diabetic Neuropathy
BioDelivery Sciences International
NCT02410499 WITHDRAWN Efficacy and Safety of Weekly Subcutaneous MLN1202 in Improving Diabetic Nephropathy in Participants With Macroalbuminuria
Takeda
NCT02643251 COMPLETED The Efficacy and Safety of Clonidine Hydrochloride Topical Gel, vs Clonidine Hydrochloride Gel Comparator to Treat Painful Diabetic Neuropathy
BioDelivery Sciences International
NCT02355158 COMPLETED A Safety Study of Clonidine Hydrochloride Topical Gel, 0.1% in the Treatment of Painful Diabetic Neuropathy
BioDelivery Sciences International
NCT02676401 COMPLETED An Extended Treatment Study of MT-3995 in Patients With Diabetic Nephropathy
Tanabe Pharma Corporation
NCT02790775 COMPLETED Pain and Visual Outcome in Intravitreal Bevacizumab Injection
Shahid Beheshti University of Medical Sciences
NCT01565148 TERMINATED A Randomized, Multi-center, Phase II Study of the Safety, Tolerability and Bioactivity of Repeated Intravitreal Injections of iCo-007 as Monotherapy or in Combination With Ranibizumab or Laser Photocoagulation in the Treatment of Diabetic Macular Edema (the iDEAL Study)
Johns Hopkins University
NCT01424319 COMPLETED Reducing Residual Albuminuria in Subjects With Diabetes and Nephropathy With Atrasentan
AbbVie (prior sponsor, Abbott)
NCT02215252 COMPLETED A Clinical Trial To Evaluate PF-05089771 On Its Own And As An Add-On Therapy To Pregabalin (Lyrica) For The Treatment Of Pain Due To Diabetic Peripheral Neuropathy (DPN)
Pfizer
NCT01726816 COMPLETED Efficacy and Safety Study of Probucol in Patients With Diabetic Nephropathy
Korea Otsuka Pharmaceutical Co., Ltd.
NCT01077401 COMPLETED Ranibizumab for Edema of the Macula in Diabetes: Protocol 3 With High Dose - the READ 3 Study
Johns Hopkins University
NCT02735369 TERMINATED A Study Assessing Efficacy and Safety of OC-10X in the Treatment of PDR
OcuCure Therapeutics, Inc.
NCT02251067 COMPLETED Phase 2 Study to Evaluate Safety & Efficacy of VPI-2690B in Diabetic Nephropathy Patients
Vascular Pharmaceuticals, Inc.
NCT02050828 COMPLETED The TIME-2 Study: A Phase 2 Study of AKB-9778, a Novel Tie-2 Activator, in Patients With Diabetic Macular Edema
Aerpio Therapeutics
NCT00901186 COMPLETED Efficacy and Safety of Ranibizumab (Intravitreal Injections) Versus Laser Treatment in Patients With Visual Impairment Due to Diabetic Macular Edema
Novartis Pharmaceuticals
NCT02517320 COMPLETED Efficacy and Safety of MT-3995 in Patients With Diabetic Nephropathy
Tanabe Pharma Corporation
NCT01935167 COMPLETED To Determine the Efficacy and Safety of DW1029M on Microalbuminuria in Patients With Diabetic Nephropathy
Dong Wha Pharmaceutical Co. Ltd.
NCT00695565 COMPLETED Efficacy and Safety Study of ARC-4558 for Management of Pain Associated With Painful Diabetic Neuropathy
Arcion Therapeutics Inc
NCT01843387 COMPLETED Safety and Efficacy of Mesenchymal Precursor Cells in Diabetic Nephropathy
Mesoblast, Ltd.
NCT01928381 COMPLETED Safety, Tolerability and Preliminary Efficacy of AZD5213 in Combination With Pregabalin in Subjects With PDN and Good Pain Reporting Ability
AstraZeneca
NCT01951066 COMPLETED Diabetic Macular Edema Treated With Ozurdex (DMEO)
Johns Hopkins University
NCT01923597 COMPLETED Effect of Green Tea (Epigallocatechin Gallate) on Albuminuria in Patients With Diabetic Nephropathy.
University of Campinas, Brazil
NCT02663141 COMPLETED Randomized Clinical Trial of Intravitreal Bevacizumab Versus Intravitreal Bevacizumab Combined With Losartan in the Treatment of Diabetic Macular Edema
Tehran University of Medical Sciences
NCT00993018 TERMINATED A Study of Effectiveness and Safety of JNJ-42160443 in Patients With Diabetic Painful Neuropathy
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
NCT02349516 WITHDRAWN Squalamine Lactate Eye Drops in Combination With Ranibizumab in Patients With Diabetic Macular Edema (DME)
Starr Muscle
NCT02118831 COMPLETED Systemic Pharmacokinetics Following Intravitreal Injections of Anti-VEGF
California Retina Consultants
NCT01292798 COMPLETED Ranibizumab 0.5mg and 2.0mg to Treat Diabetic Macular Edema in Patients With Poor Response to Bevacizumab
California Retina Consultants
NCT01823965 COMPLETED Intravitreal Injections of Ranibizumab With Deferred Laser Grid Laser Photocoagulation for Treatment of Diabetic Macular Edema With Visual Impairment
Poitiers University Hospital
NCT00734253 COMPLETED Safety and Efficacy Study of Pyridorin in Patients With Nephropathy Due to Type 2 Diabetes
NephroGenex, Inc.
NCT02314299 COMPLETED A Study of MTP-131 Topical Ophthalmic Solution in Subjects With Diabetic Macular Edema and Non-Exudative Intermediate Age-related Macular Degeneration
Stealth BioTherapeutics Inc.
NCT01712061 COMPLETED A Phase 2 Multi-Center Study To Evaluate The Efficacy And Safety Of A Chemokine CCR2/5 Receptor Antagonist In Adults With Type 2 Diabetes And Overt Nephropathy
Pfizer
NCT01280929 COMPLETED Prospective, Randomized, Multicenter, Open Label, Phase II Study to Access Efficacy and Safety of Lucentis® Monotherapy Compared With Lucentis® Plus Panretinal Photocoagulation (PRP) and PRP in the Treatment of Patients With High Risk Proliferative Diabetic Retinopathy
José Cunha-Vaz
NCT02205372 COMPLETED Safety, Tolerability and Pharmacokinetic Study of MT-3995 at a Low Dose in Subjects With Diabetic Nephropathy
Tanabe Pharma Corporation
NCT00837941 WITHDRAWN A Study of Single Dose Pain Therapy in Patients With Painful Diabetic Neuropathy (0000-115)
Merck Sharp & Dohme LLC
NCT01521598 COMPLETED A Phase 2, Multicenter, Randomized, Double-blind, Placebo Controlled Study for the Pain of Diabetic Peripheral Neuropathy
SK Life Science, Inc.
NCT01298076 COMPLETED Intravitreal Bevacizumab (Avastin®) Versus Intravitreal Dexamethasone (Ozurdex™) for Persistent Diabetic Macular Oedema
University of Sydney
NCT01724554 COMPLETED Impact of Intravitreal Aflibercept Injections on Capillary Non-Perfusion
Ophthalmic Consultants of Boston
NCT01702441 COMPLETED Safety and Pilot Efficacy of AKB-9778 in Subjects With Diabetic Macular Edema
Aerpio Therapeutics
NCT00900887 COMPLETED Topic Antiinflammatory Therapy Added to Selective Photocoagulation in Macular Edema
Hospital Juarez de Mexico
NCT00907114 COMPLETED Topic Ketorolac Added to Panphotocoagulation in Proliferative Diabetic Retinopathy
Hospital Juarez de Mexico
NCT01281098 COMPLETED Prospective, Randomized, Open Label, Phase II Study to Assess Efficacy and Safety of Macugen® (Pegaptanib 0.3 mg Intravitreal Injections) Plus Panretinal Photocoagulation and PRP (Monotherapy) in the Treatment With High Risk PDR.
Association for Innovation and Biomedical Research on Light and Image
NCT00815360 COMPLETED Ranibizumab and Peripheral Scatter Laser in Patients With Diabetic Macular Edema and Peripheral Nonperfusion
Retina Associates of Florida, P.A.
NCT01793350 WITHDRAWN Safety and Efficacy Study of BC-DN-01 in Painful Diabetic Peripheral Neuropathy
BioChemics, Inc.
NCT01445899 COMPLETED PF-04523655 Dose Escalation Study, and Evaluation of PF-04523655 With/Without Ranibizumab in Diabetic Macular Edema (DME)
Quark Pharmaceuticals
NCT01756716 COMPLETED A Study to Evaluate Pharmacodynamics, Safety, Tolerability and Pharmacokinetics of MT-3995 in Type II Diabetic Nephropathy Subjects With Albuminuria and Moderately Decreased GFR
Tanabe Pharma Corporation
NCT01756703 COMPLETED A Study to Evaluate Pharmacodynamics, Safety, Tolerability and Pharmacokinetics of MT-3995 in Type II Diabetic Nephropathy Subjects With Albuminuria
Tanabe Pharma Corporation
NCT01889277 COMPLETED Safety, Tolerability and Pharmacokinetic Study of MT-3995 in Subjects With Diabetic Nephropathy
Tanabe Pharma Corporation
NCT01120899 COMPLETED A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Diabetic Macular Edema
National Eye Institute (NEI)
NCT00789477 COMPLETED DME And VEGF Trap-Eye [Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321)] INvestigation of Clinical Impact
Regeneron Pharmaceuticals
NCT01112085 COMPLETED MIcrodoses of raNIbizumab in Diabetic MAcular Edema (MINIMA-2)
Especialistas en Retina Medica y Quirurgica Grupo de Investigacion
NCT01493050 COMPLETED The Effects of Sevelamer Carbonate on Diabetic Nephropathy
Gary Striker
NCT01472510 COMPLETED Ranibizumab in Residual Diabetic Macular Edema Following Previous Anti-VEGF Therapy
Vitreo-Retinal Associates, PC
NCT02062034 COMPLETED Efficacy of Ubiquinone and Combined Antioxidant Therapy in Non-proliferative Diabetic Retinopathy
University of Guadalajara
NCT02002403 COMPLETED Efficacy and Safety Study to Evaluate Two Doses of Oral DMI-5207 in Adult Subjects With Diabetic Macular Edema
Unity Health Toronto
NCT01399580 COMPLETED A Prospective, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate Efficacy and Safety of Atrasentan, Including Thoracic Bioimpedance, in Type 2 Diabetic Subjects With Nephropathy
AbbVie (prior sponsor, Abbott)
NCT01356849 COMPLETED Evaluate the Efficacy and Safety of Once Daily Administration of Atrasentan Tablets (Low and High) Compared to Placebo in Reducing Residual Albuminuria in Type 2 Diabetic Patients With Nephropathy Who Are Treated With the Maximum Tolerated Labeled Dose of a Renin Angiotensin System (RAS) Inhibitor
AbbVie (prior sponsor, Abbott)
NCT00781001 COMPLETED Efficacy of Inhaled Cannabis in Diabetic Painful Peripheral Neuropathy
Center for Medicinal Cannabis Research
NCT01373476 COMPLETED Multicentre, Randomized, Controlled Trial of Qideng Mingmu Capsule in The Treatment of Diabetic Retinopathy
Chengdu University of Traditional Chinese Medicine
NCT01253694 WITHDRAWN Ranibizumab as a Rescue Therapy for Diabetic Macular Edema
New England Retina Associates
NCT01324869 COMPLETED Safety and Efficacy by Multiple Injection of KH902 in Patients With Diabetic Macular Edema (DME)
Chengdu Kanghong Biotech Co., Ltd.
NCT01293461 COMPLETED Safety and Pharmacokinetics of CBX129801 in Patients With Type 1 Diabetes
Cebix Incorporated
NCT00656643 COMPLETED Dose Ranging Study of an Ocular Sirolimus (Rapamycin) Formulation in Patients With Diabetic Macular Edema
Santen Inc.
NCT01746563 COMPLETED Intravitreal Ranibizumab Combined With Panretinal Photocoagulation in Patients With Proliferative Diabetic Retinopathy
University of Sao Paulo
NCT01482871 WITHDRAWN Safety Study of ALG- 1001 to Treat Diabetic Macular Edema
Allegro Ophthalmics, LLC
NCT00857623 COMPLETED Study to Evaluate the Analgesic Efficacy of 28 Days' Oral Administration of AZD2066 Compared With Placebo in Patients With Painful Diabetic Neuropathy
AstraZeneca
NCT01295775 COMPLETED Diabetic Retinopathy Sulodexide Study
Ajou University School of Medicine
NCT00701181 TERMINATED Study Evaluating Efficacy and Safety of PF-04523655 Versus Laser in Subjects With Diabetic Macular Edema
Quark Pharmaceuticals
NCT01284478 COMPLETED Ozurdex for Combined Pseudophakic Cystoid Macular Edema and Diabetic Macular Edema After Cataract Surgery
Northern California Retina Vitreous Associates
NCT01667614 COMPLETED Effects of Spironolactone Combination Therapy on Proteinuria, Kidney Function, and Blood Pressure
Tehran University of Medical Sciences
NCT01319487 COMPLETED Safety and Efficacy Study of Topical Administration of FOV2304 (High Dose or Low Dose) for the Treatment of Center-involving Clinically Significant Macular Edema Associated With Diabetic Retinopathy
Fovea Pharmaceuticals SA
NCT01003236 COMPLETED Evaluating the Renoprotective Effect of Milk Thistle Extract on Patients With Type II Diabetic Nephropathy
Shiraz University of Medical Sciences
NCT00785577 COMPLETED A Study for Treatment of Pain in Patients With Diabetic Neuropathy.
Eli Lilly and Company
NCT00768040 TERMINATED Efficacy of Aliskiren in the Treatment of Diabetic Macular Edema
Novartis Pharmaceuticals
NCT00683176 COMPLETED Effect of Choline Fenofibrate (SLV348) on Macular Edema
Abbott Products
NCT01102946 COMPLETED Panretinal Photocoagulation (PRP) Plus Ranibizumab for Proliferative Diabetic Retinopathy
University of Sao Paulo
NCT00776763 COMPLETED Ocular Growth Factors Profile in Proliferative Retinopathies Before and After Intravitreal Bevacizumab
Ophthalmological Association Edelweiss
NCT01201161 COMPLETED Ranibizumab for Diabetic Traction Retinal Detachment
University of Sao Paulo
NCT00874744 COMPLETED Comparison of Single Intravitreal Injection of Triamcinolone or Bevacizumab for the Treatment of Diabetic Macular Edema
Universidade Federal de Goias
NCT00864838 COMPLETED Oral Acetazolamide, Brimonidine Tartarate, and Anterior Chamber Paracentesis for Ocular Hypertension Control After Intravitreal Bevacizumab
University of Sao Paulo
NCT00690768 COMPLETED Pars Plana Vitrectomy (PPV) Versus Preoperative Intravitreal Bevacizumab Plus PPV to Treat Diabetic Tractional Retinal Detachment (IBETRA)
University of Sao Paulo