Data updated: Jun 28, 2026
Endometriosis Clinical Trial Landscape
Endometriosis is being studied across 160 clinical trials registered since 2008, with 29 programs currently active. The competitive pipeline includes 12 active Phase 3 trials, 7 active Phase 2 trials, and 1 active Phase 1 trials.
Trial activity
29 active / 160 total since 2008
Active by phase 12 Ph3 / 44 7 Ph2 / 66 1 Ph1 / 21 9 Ph4 / 29
Sponsor activity
Who is running trials now — green active, blue completed, red failed/terminated.
Sorted by active Active Done Failed
AbbVie 1 7 1
Kissei Pharmaceutical Co., Ltd. 1 3 2
Hope Medicine (Nanjing) Co., Ltd 1 1 0
Gesynta Pharma AB 1 0 0
Changchun GeneScience Pharmaceutical Co., Ltd. 1 0 0
Sumitomo Pharma Switzerland GmbH 1 0 0
Jiangsu Hansoh Pharmaceutical Co., Ltd. 1 0 0
Bio Meds Pharmaceutica Ltda 1 0 0
Hera Biotech, Inc. 1 0 0
Bayer 0 17 3
Jiangsu HengRui Medicine Co., Ltd. 0 3 0
Myovant Sciences GmbH 0 3 0
Repros Therapeutics Inc. 0 1 2
How the field has grown
New-trial starts peaked in 2020 (15 registered); 2025 saw 10. The right-hand chart shows median Phase 3 enrollment by start year — the number in parentheses is that year's Phase 3 trial count (31 in total), so single-trial years (and years with no Phase 3 starts) are obvious. Both are by trial start date; the current year is partial.
New trials started by year
2016 9
2017 9
2018 10
2019 12
2020 15
2021 6
2022 9
2023 11
2024 11
2025 10
2026 6
TheraRadar.com
Median Phase 3 enrollment by start year
2016 (0) 0
2017 (5) 623
2018 (2) 402
2019 (3) 335
2020 (5) 30
2021 (1) 180
2022 (1) 103
2023 (6) 141
2024 (4) 77
2025 (3) 288
2026 (1) 540
TheraRadar.com
Full trial pipeline
Every active and completed trial across Phase 1–4, with enrollment analytics. Sortable, filterable, exportable with Pro.
NCT07015268 ACTIVE NOT RECRUITING
A Clinical Study of KLH-2109 in Patients With Endometriosis
Kissei Pharmaceutical Co., Ltd. n=288
NCT07100782 RECRUITING
Estradiol-mediated Inflammation and Central Sensitization in the Pathophysiology of Endometriosis-associated Pelvic Pain
University of Michigan n=130
NCT04356664 RECRUITING
Benefit of GnRH Agonist Before Frozen Embryo Transfer in Patients With Endometriosis and/or Adenomyosis
Hopital Foch n=180
NCT07318688 NOT YET RECRUITING
Evaluate the Efficacy and Safety of HMI-115 in Women With Moderate to Severe Endometriosis-associated Pain
Hope Medicine (Nanjing) Co., Ltd n=540
NCT05726786 RECRUITING
The Role of Preoperative Immunonutrition on Morbidity and Immune Response After Cystectomy (INCyst Trial)
Centre Hospitalier Universitaire Vaudois n=232
NCT04333576 ACTIVE NOT RECRUITING
Study Of Oral Elagolix Tablets In Combination With Combined Oral Contraceptive Capsules/Tablets To Assess Dysmenorrhea Response In Adult Female Participants With Endometriosis And Associated Moderate To Severe Pain
AbbVie n=800
NCT07164183 RECRUITING
Clinical Study to Compare Efficacy and Safety of Indinol Forto® 200 mg Capsules and Visanne 2 mg Tablets in Treatment of Endometriosis
Alcea n=290
NCT05862272 RECRUITING
A Phase 3B Study to Evaluate Bone Mineral Density With Long-Term Use of Relugolix Combination Tablet in Women With Uterine Fibroids or Endometriosis
Sumitomo Pharma Switzerland GmbH n=1,000
NCT06375811 ACTIVE NOT RECRUITING
Pre-IVF Treatment With a GnRH Antagonist in Women With endometriosis_temp
Yale University n=97
NCT06439524 RECRUITING
The Effect of Medical Management Following Excisional Surgery for Endometriosis: A Randomized Controlled Trial
Main Line Health n=110
NCT06161805 RECRUITING
Esketamine as Treatment for Chronic Pain Due to Endometriosis: a RCT Study
Reinier de Graaf Groep n=56
NCT06525155 RECRUITING
Effect GnRH Agonist Administration in Endometriosis Cyst Patients
Rumah Sakit Pusat Angkatan Darat Gatot Soebroto n=32
NCT04831619 COMPLETED
Contribution of PET (Positron Emission Tomography) Scans for the Preoperative Assessment of Symptomatic Endometriosis Lesions: TEP-ENDORUN
Centre Hospitalier Universitaire de la Réunion n=15
NCT01973816 COMPLETED
MEdical Versus SUrgical Treatments of Rectal Endometriosis
University Hospital, Rouen n=78
NCT06076486 COMPLETED
A Clinical Trial to Evaluate Efficacy and Safety of Elagolix Tablets in Women With Moderate or Severe Endometriosis-associated Pain
Nanjing Chia-tai Tianqing Pharmaceutical n=202
NCT04173169 COMPLETED
Pre-IVF Treatment With a GnRH Antagonist in Women With Endometriosis
Yale University n=103
NCT04527003 TERMINATED
Cannabidiol and Management of Endometriosis Pain
Milton S. Hershey Medical Center n=12
NCT04335591 COMPLETED
Extension to Study on Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain (EDELWEISS 6)
Kissei Pharmaceutical Co., Ltd. n=356
NCT03986944 TERMINATED
A Phase 3 Study to Confirm the Efficacy and Safety of Linzagolix to Treat Endometriosis-associated Pain
Kissei Pharmaceutical Co., Ltd. n=85
NCT03992846 COMPLETED
Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain.
Kissei Pharmaceutical Co., Ltd. n=486
NCT04372121 TERMINATED
Extension to Study on Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain
Kissei Pharmaceutical Co., Ltd. n=30
NCT05670353 TERMINATED
Cannabidiol for the Treatment of Pelvic Pain in Endometriosis (DREAMLAND)
University of Sao Paulo n=50
NCT03213457 COMPLETED
A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain
AbbVie n=681
NCT06145438 COMPLETED
Comparing the Safety and Efficacy in the Use of Hormonal Therapy on Endometriosis Patients After Conservative Surgery
Universitas Diponegoro n=80
NCT01712763 COMPLETED
Degarelix in the Treatment of Endometriosis Recurrence
Centre for Endocrinology and Reproductive Medicine, Italy n=360
NCT03654274 COMPLETED
SPIRIT EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Endometriosis-Associated Pain
Myovant Sciences GmbH n=802
NCT03970330 TERMINATED
Low-Dose Naltrexone in Combination With Standard Treatment in Women With Endometriosis
Milton S. Hershey Medical Center n=9
NCT02437175 COMPLETED
Efficacy of Trace Elements in the Treatment of Endometriosis: a Pilot Study
Laboratoires Pronutri n=99
NCT03232281 COMPLETED
Study to Compare the Oestradiol Suppression, Clinical Efficacy and Safety of Two Formulations of Triptorelin (Triptorelin Pamoate PR 3-month and Triptorelin Acetate PR 1-month) in Chinese Subjects With Endometriosis
Ipsen n=300
NCT01760954 COMPLETED
Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Adults With Moderate to Severe Endometriosis-Associated Pain
AbbVie n=506
NCT02143713 COMPLETED
Global Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Women With Moderate to Severe Endometriosis-associated Pain
AbbVie n=496
NCT03204331 COMPLETED
SPIRIT 2: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain
Myovant Sciences GmbH n=623
NCT03204318 COMPLETED
SPIRIT 1: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain
Myovant Sciences GmbH n=638
NCT03931915 COMPLETED
Clinical Study to Evaluate Efficacy and Safety of TAK-385 40 mg Compared With Leuprorelin in Patients With Endometriosis
ASKA Pharmaceutical Co., Ltd. n=335
NCT02669238 TERMINATED
Evaluation of a Subcutaneous Progestogen Implants in the Medical Management of Painful Endometriosis
Centre Hospitalier Universitaire de la Réunion n=2
NCT03343067 TERMINATED
A Study to Evaluate Safety and Efficacy of Elagolix in Participants With Endometriosis With Associated Moderate to Severe Pain
AbbVie n=11
NCT01620528 COMPLETED
A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain
AbbVie (prior sponsor, Abbott) n=872
NCT01931670 COMPLETED
A Global Phase 3 Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain
AbbVie n=815
NCT02599077 SUSPENDED
Impact vs. Dienogest: A Combined Oral Contraceptive in the Size of Endometriomas
Fundación Santa Fe de Bogota n=50
NCT01697111 COMPLETED
Comparative Study of BAY86-5300 With an Extended Flexible Regimen for Endometriosis
Bayer n=312
NCT01822080 COMPLETED
Phase 3 Study of Dienogest for the Treatment of Endometriosis in Chinese Patients
Bayer n=250
NCT02271958 COMPLETED
Mifepristone 2.5, 5, 10 mg Versus Placebo in the Treatment of Endometriosis
Mediterranea Medica S. L. n=360
NCT00865488 SUSPENDED
Evaluation of Adhexil Safety and Efficacy in Prevention and/or Reduction of Adhesions in Gynecological Surgery
OMRIX Biopharmaceuticals n=80
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only