TheraRadar
Landscape / Endocrine
Data updated: Jun 28, 2026

Hypothyroidism Clinical Trial Landscape

Hypothyroidism is being studied across 41 clinical trials registered since 2008, with 6 programs currently active. The competitive pipeline includes 4 active Phase 3 trials, 1 active Phase 2 trials, and 0 active Phase 1 trials.

Top industry sponsors include AbbVie.

Trial activity

6 active / 41 total since 2008
Active by phase 4 Ph3 / 10 1 Ph2 / 10 0 Ph1 / 0 1 Ph4 / 21

Sponsor activity

Who is running trials now — green active, blue completed, red failed/terminated.

Sorted by active Active Done Failed
AbbVie 1 1 0

How the field has grown

New-trial starts peaked in 2018 (4 registered); 2025 saw 0. The right-hand chart shows median Phase 3 enrollment by start year — the number in parentheses is that year's Phase 3 trial count (7 in total), so single-trial years (and years with no Phase 3 starts) are obvious. Both are by trial start date; the current year is partial.

New trials started by year

2016
0
2017
2
2018
4
2019
2
2020
2
2021
4
2022
4
2023
2
2024
4
2025
0
2026
1

TheraRadar.com

Median Phase 3 enrollment by start year

2016 (0)
0
2017 (1)
160
2018 (1)
32
2019 (0)
0
2020 (0)
0
2021 (1)
68
2022 (1)
600
2023 (0)
0
2024 (3)
90
2025 (0)
0
2026 (0)
0

TheraRadar.com

Full trial pipeline

Every active and completed trial across Phase 1–4, with enrollment analytics. Sortable, filterable, exportable with Pro.

NCT06731764 RECRUITING
Novel Approaches to the Treatment of Hypothyroidism
UConn Health n=90
NCT06345339 RECRUITING
A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants
AbbVie n=2,800
NCT05682482 RECRUITING
LT4/LT3 Combination Therapy Versus LT4 Monotherapy in Patients with Autoimmune Hypothyroidism.
M. Medici n=600
NCT05316922 RECRUITING
TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer Patients
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano n=68
NCT06276205 COMPLETED
Vitamin D & Levothyroxine Combination Versus Levothyroxine on Lipid Profile in Hypothyroidism
King Edward Medical University n=62
NCT03053115 COMPLETED
Combined Replacement Therapy With Levothyroxine and Liothyronine in Thyroidectomized Patients
Azienda USL Modena n=160
NCT02548715 WITHDRAWN
Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery
University of Alberta
NCT03898622 COMPLETED
Supplementation of Thyroid Hormone for TSH Control in Patients With Chronic Kidney Disease Without TRR.
Hospital Civil de Guadalajara n=32
NCT02090907 COMPLETED
Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism
Isfahan University of Medical Sciences n=50
NCT00921050 COMPLETED
Subclinical Hypothyroidism and Mind in the Elderly
Universidad Autonoma de Nuevo Leon n=70

Full Hypothyroidism Pipeline

Every trial across Phase 1–4, plus enrollment analytics. Sortable, filterable, exportable.

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Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only