TheraRadar
Landscape / Hepatology
Data updated: Jun 28, 2026

Liver Failure Clinical Trial Landscape

Liver Failure is being studied across 79 clinical trials registered since 2008, with 29 programs currently active. The competitive pipeline includes 5 active Phase 3 trials, 14 active Phase 2 trials, and 9 active Phase 1 trials.

Top industry sponsors include Yaqrit Ltd, eGenesis, INC, Quell Therapeutics Limited.

Trial activity

29 active / 79 total since 2008
Active by phase 5 Ph3 / 14 14 Ph2 / 35 9 Ph1 / 22 1 Ph4 / 8

Sponsor activity

Who is running trials now — green active, blue completed, red failed/terminated.

Sorted by active Active Done Failed
Yaqrit Ltd 2 0 0
eGenesis, INC 1 0 0
Quell Therapeutics Limited 1 0 0
Gilead 1 0 0
Beijing Continent Pharmaceutical Co, Ltd. 1 0 0
Dr. F. Köhler Chemie GmbH 1 0 0
Hexaell Biotech Co., Ltd. 1 0 0
Genfit 0 1 2
Vital Therapies, Inc. 0 0 3

All 9 active Liver Failure sponsors

Unlock the remaining 1 sponsors with active / completed / failed counts — sortable and exportable.

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How the field has grown

New-trial starts peaked in 2025 (11 registered). The right-hand chart shows median Phase 3 enrollment by start year — the number in parentheses is that year's Phase 3 trial count (7 in total), so single-trial years (and years with no Phase 3 starts) are obvious. Both are by trial start date; the current year is partial.

New trials started by year

2016
6
2017
0
2018
3
2019
4
2020
2
2021
3
2022
4
2023
9
2024
4
2025
11
2026
4

TheraRadar.com

Median Phase 3 enrollment by start year

2016 (2)
117
2017 (0)
0
2018 (0)
0
2019 (2)
318
2020 (0)
0
2021 (0)
0
2022 (0)
0
2023 (0)
0
2024 (0)
0
2025 (2)
78
2026 (1)
72

TheraRadar.com

Full trial pipeline

Every active and completed trial across Phase 1–4, with enrollment analytics. Sortable, filterable, exportable with Pro.

NCT07347275 NOT YET RECRUITING
A Novel Extracorporeal Liver Support Therapy In ALCF and to Evaluate the Efficacy of DIALIVE 2.0, a Liver Dialysis Device.
Yaqrit Ltd n=72
NCT03627013 RECRUITING
Custodiol-N Solution Compared With Custodiol Solution in Organ Transplantation (Kidney, Liver and Pancreas)
Dr. F. Köhler Chemie GmbH n=362
NCT07075315 NOT YET RECRUITING
National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial
Institute of Liver and Biliary Sciences, India n=100
NCT06884904 NOT YET RECRUITING
Umbilical Cord-derived Mesenchymal Stem Cell Infusion for Treating ACLF
National Engineering Center of Cell Products n=96
NCT06815770 NOT YET RECRUITING
Efficacy and Safety of Continuous Infusion of Terlipressin vs Bolus Terlipressin in ACLF Patients With Acute Esophageal Variceal Bleed
Institute of Liver and Biliary Sciences, India n=60
NCT03702920 TERMINATED
Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5%
Instituto Grifols, S.A. n=274
NCT02837939 WITHDRAWN
Transfer Factor Efficacy in the Management of Cirrhosis-associated Immune Dysfunction
Martin Janičko
NCT02584283 COMPLETED
Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation
Robert J. Porte n=157
NCT02786836 COMPLETED
13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF
University of Texas Southwestern Medical Center n=76
NCT01785082 COMPLETED
Fast-track LiveR: Study for the Early Identification of Low-risk Patients After Partial Liver Resection by the LiMAx-test
Humedics GmbH n=149
NCT01160978 COMPLETED
Donor Simvastatin Treatment in Organ Transplantation
Helsinki University Central Hospital n=84
NCT01383460 COMPLETED
Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure
Institute of Liver and Biliary Sciences, India n=55
NCT02552901 WITHDRAWN
Cardiox Liver Function Test Pivotal Trial
Cardiox Corporation
NCT01452295 WITHDRAWN
Registry Protocol for Tracking Trial Subjects After VTI-206 Study Completion
Vital Therapies, Inc.

Full Liver Failure Pipeline

Every trial across Phase 1–4, plus enrollment analytics. Sortable, filterable, exportable.

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Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only