NCT06735209 ACTIVE NOT RECRUITING First-in-Human PfSPZ-LARC2 Vaccination/CHMI
National Institute of Allergy and Infectious Diseases (NIAID)
NCT07558122 NOT YET RECRUITING Malaria CVD 36000; Gates INV090205
University of Maryland, Baltimore
NCT06607003 RECRUITING Induced Blood-Stage Malaria in Healthy Malaria-Naive Adults to Assess the Safety and Infectivity of Plasmodium Vivax Challenge Agent and Evaluate Transmission in Mosquito Feeding Assays
National Institute of Allergy and Infectious Diseases (NIAID)
NCT07548021 NOT YET RECRUITING Safety and PK of MMV371 LAI in Healthy Adults and Adolescents in Rwanda
Medicines for Malaria Venture
NCT06862453 RECRUITING Safety, Tolerability and Efficacy of PfSPZ-LARC2 Vaccine Against CHMI in Malaria-Naïve Adults
Sanaria Inc.
NCT06320535 ACTIVE NOT RECRUITING A Phase 1 Study to Assess an Escalating Dose, Multi-prime Vaccination Schedule of R21/Matrix-M™
University of Oxford
NCT07470424 NOT YET RECRUITING A Clinical Study of Piperaquine, Pyronaridine, and Artesunate Administered in Combination in Healthy Adults
University of Oxford
NCT06171113 RECRUITING A Study to Investigate the Safety of GSK4024484 in Healthy Adult Participants
GlaxoSmithKline
NCT06958198 RECRUITING A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 Combined With R21/Matrix-M (a "Multi-stage" Malaria Vaccine)
University of Oxford
NCT07124156 NOT YET RECRUITING A Challenge Study to Assess the Blood-stage Efficacy of Full-length SUM-101 Malaria Vaccine Candidate
European Vaccine Initiative
NCT06618885 ACTIVE NOT RECRUITING Safety and Immunogenicity of SUM-101 Malaria Vaccine in Children and Infants Living in Burkina Faso
European Vaccine Initiative
NCT06461026 ACTIVE NOT RECRUITING L9LS MAb in Malian Infants
National Institute of Allergy and Infectious Diseases (NIAID)
NCT06854042 RECRUITING A Study of Oral E1018 in Healthy Adult Participants
Eisai Inc.
NCT07172724 NOT YET RECRUITING Clinical Trial to Evaluate the Safety and Immunogenicity of the Vivaxin Vaccine for Malaria Caused by Plasmodium Vivax."
Federal University of Minas Gerais
NCT07011511 RECRUITING Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of LAI MMV055 Alone and in Combination With MMV371 in Healthy Participants
Medicines for Malaria Venture
NCT06881732 NOT YET RECRUITING Experimental Malaria Infection of Healthy Malaria-Naive Adults by Mosquito Bite With the Genetically Modified Plasmodium Falciparum NF54/iGP3 GAP
University of Melbourne
NCT06293339 NOT YET RECRUITING Durability of Protection After Single Immunisation With GA2 Sporozoites (CoGA-Rechallenge)
Leiden University Medical Center
NCT06141057 ACTIVE NOT RECRUITING A Study to Compare Two Dosing Regimens for a New Malaria Vaccine
University of Oxford
NCT05911828 RECRUITING A Study to Determine Safety, Tolerability, and Pharmacokinetics of Different Orally Administered Regimens of the Combination ZY19489-Ferroquine in Adult Asymptomatic Plasmodium Falciparum Carriers
Zydus Lifesciences Limited
NCT07646353 NOT YET RECRUITING First-in-Human Dose-escalation of GSK4425689A: Safety, Tolerability, and PK in Healthy Adults
GlaxoSmithKline
NCT07670377 NOT YET RECRUITING Drug-Interaction Assessment of GSK3772701 in Healthy Male and Female Participants Aged 18 to 55 Years
GlaxoSmithKline
NCT05652504 SUSPENDED Safety Evaluation of PfSPZ Vaccine in Pregnant Women in Mali (MalVIP1)
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05357560 COMPLETED A Study to Assess the Experimental Malaria Vaccines RH5.2-VLP and R21
University of Oxford
NCT06558643 COMPLETED Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of MMV371 LAI in Healthy Participants
Medicines for Malaria Venture
NCT06652737 COMPLETED Age De-escalation Safety Trial of PfSPZ-LARC2 Vaccine in Burkina Faso
Sanaria Inc.
NCT05155579 COMPLETED Assessment of Safety and Immunogenicity of a Single Vial Presentation of R21/Matrix-M and Co-Administration With EPI Vaccines
University of Oxford
NCT05385510 COMPLETED Assessment of Safety and Immunogenicity of R21/Matrix-M™ in African Children Living With HIV
University of Oxford
NCT06507605 COMPLETED Dose-Escalating Study of Pfs230D1 in Combination With R21 in Matrix-M in African Adults
Serum Institute of India Pvt. Ltd.
NCT05979207 COMPLETED Phase 1b MMV367 PK/PD and Safety in Healthy Adult Volunteers Experimentally Infected With Blood Stage P. Falciparum
Medicines for Malaria Venture
NCT02658253 COMPLETED Trial to Evaluate the Safety and Immunogenicity of a Placental Malaria Vaccine Candidate (PRIMVAC ) in Healthy Adults
Institut National de la Santé Et de la Recherche Médicale, France
NCT02014727 COMPLETED Safety and Immunogenicity of Recombinant Pichia Pastoris AMA1-DiCo Candidate Malaria Vaccine With GLA-SE and Alhydrogel ® as Adjuvant in Healthy Malaria Non-Exposed European and Malaria Exposed African Adults
Institut National de la Santé Et de la Recherche Médicale, France
NCT05913973 COMPLETED Study of the Plasmodium Vivax Transmission-blocking Vaccine Pvs230D1-EPA/Matrix-M to Assess Safety, Immunogenicity, and Transmission-blocking Activity in Healthy Malaria-naive Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05581641 COMPLETED Safety and Immune Responses After Vaccination With an Investigational RNA-based Vaccine Against Malaria
BioNTech SE
NCT05905432 COMPLETED Pan-Malaria Transmission-Blocking Vaccine AnAPN1
Centre de Recherche Médicale de Lambaréné
NCT05287893 COMPLETED Pyronaridine in Healthy Adult Participants Infected With Blood Stage Malaria
Medicines for Malaria Venture
NCT05930782 COMPLETED Piperaquine Granule Formulation Relative Bioavailability and Food Effect Study in Healthy Volunteers.
Medicines for Malaria Venture
NCT04862416 COMPLETED Safety and Efficacy of R0.6C Vaccine
Radboud University Medical Center
NCT03168854 COMPLETED Trial to Evaluate the Safety, Immunogenicity and Protective Efficacy of Three or Five Administrations of GAP3KO Sporozoites
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05891236 COMPLETED Safety, Tolerability, Pharmacokinetics and Protective Efficacy of MAM01 in Healthy Adults
Gates Medical Research Institute
NCT05507970 COMPLETED First-in-Human Study to Assess the Safety, Tolerability and Pharmacokinetics of MMV367
Medicines for Malaria Venture
NCT04271306 TERMINATED Safety, Immunogenicity and ex Vivo Efficacy of Pfs25-IMX313/Matrix-M in Healthy Volunteers in Bagamoyo, Tanzania.
University of Oxford
NCT06294912 COMPLETED A Study to Evaluate Antimalarial Activity and Safety of MK-7602 in Healthy Adults (MK-7602-003)
Merck Sharp & Dohme LLC
NCT02942277 COMPLETED Safety and Immunogenicity of Pfs25M-EPA/AS01 and Pfs230D1M-EPA/AS01 Vaccines, Transmission Blocking Vaccines Against Plasmodium Falciparum, at Full and Fractional Dosing in Adults in Mali
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05205941 COMPLETED MMV533 Plasmodium Falciparum Volunteer Infection Study
Medicines for Malaria Venture
NCT05604521 TERMINATED A Phase 1 Trial of PfSPZ Vaccine in Healthy Adults to Determine Safety, Tolerability and Efficacy Against Heterologous CHMI
Sanaria Inc.
NCT04318002 COMPLETED Safety and Immunogenicity of RH5.1/Matrix-M in Adults and Infants Living in Tanzania
University of Oxford
NCT04323306 COMPLETED A Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetic Profile of a Single Doses of MMV533.
Medicines for Malaria Venture
NCT05019729 COMPLETED Trial to Evaluate L9LS in Healthy Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT03542149 COMPLETED Safety, Tolerability and Antimalarial Activity of Single Doses of OZ439 and PQP
Medicines for Malaria Venture
NCT05135273 COMPLETED Study of the Transmission-Blocking Vaccine Pfs230D1-EPA/Matrix-M Against Malaria in Adults in Mali
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05644067 COMPLETED Assessment of the Malaria Vaccine Candidate SumayaVac-1 in Healthy Adults Aged 18-45 Years Living in a Malaria Endemic Country
Swiss Tropical & Public Health Institute
NCT01868438 COMPLETED Relative Bioavailability of Pyronaridine-artesunate in Tablet and Granule Formulations in Healthy Volunteers
Medicines for Malaria Venture
NCT01523002 COMPLETED Drug Interaction Study of Pyronaridine-artesunate & Metoprolol, & Redosing Study of Pyronaridine-artesunate
Medicines for Malaria Venture
NCT04327310 WITHDRAWN Clinical Study of Meplazumab to Treat With Malaria
Jiangsu Pacific Meinuoke Bio Pharmaceutical Co Ltd
NCT05095272 COMPLETED Blood-Stage Plasmodium Vivax Cell Bank
National Institute of Allergy and Infectious Diseases (NIAID)
NCT03589794 COMPLETED rCSP/AP10-602 [GLA-LSQ] Vaccine Trial
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02458092 COMPLETED Evaluate the Safety and Efficacy of Plasmodium Falciparum Malaria Protein 010 (FMP010) Administered With Adjuvant AS01B
U.S. Army Medical Research and Development Command
NCT04206332 COMPLETED Trial to Evaluate CIS43LS in Healthy Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04238689 COMPLETED Safety, Tolerability, and Pharmacokinetics and Pharmacodynamics of TB31F
Radboud University Medical Center
NCT01156389 COMPLETED Pyronaridine Artesunate-Ritonavir Drug-drug Interaction Study
Medicines for Malaria Venture
NCT05330273 COMPLETED Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Efavirenz
Novartis Pharmaceuticals
NCT05236530 COMPLETED Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Midazolam, Repaglinide, Dextromethorphan, Metformin, Rosuvastatin and Dolutegravir
Novartis Pharmaceuticals
NCT05084651 COMPLETED Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Itraconazole
Novartis Pharmaceuticals
NCT04966871 COMPLETED Safety, Tolerability and Efficacy of PfSPZ Vaccine Against Heterologous CHMI in US Malaria naïve Adults
Sanaria Inc.
NCT05206201 COMPLETED A Study Of Zy-19489 Administered Via Oral Route To Investigate The Safety, Tolerability And Pharmacokinetics In Healthy Adult Human Subjects
Zydus Lifesciences Limited
NCT01383109 COMPLETED Human Mass Balance Study of Pyronaridine
Medicines for Malaria Venture
NCT04321252 COMPLETED Study to Assess Safety, Tolerability and Phamacokinetics of KAE609 Administered Intravenously in Healthy Subjects
Novartis Pharmaceuticals
NCT04310085 COMPLETED Study in Blood Stage Malaria Infection After DVI of Cryopreserved P. Falciparum (NF54 Strain) Sporozoites
Medicines for Malaria Venture
NCT03510481 COMPLETED Safety, Immunogenicity, and Protective Efficacy of Two Regimens of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Natural Transmission Season in Healthy African Adults in Mali
National Institute of Allergy and Infectious Diseases (NIAID)
NCT03490162 TERMINATED Safety and Pharmacokinetics Study of DM1157 to Treat Malaria
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04456634 COMPLETED Assess Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profile of Ruxolitinib With Artemether-lumefantrine
Medicines for Malaria Venture
NCT03014258 COMPLETED A Systems Biology Approach to Malaria Immunity
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01540474 COMPLETED Trial of a Falciparum Malaria Protein (FMP012), E. Coli-expressed PfCelTOS, in Healthy Malaria-Naive Adults
U.S. Army Medical Research and Development Command
NCT03083847 COMPLETED Dose Escalation PfSPZ-CVac
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02627456 COMPLETED Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites in Healthy African Adults in Mali
National Institute of Allergy and Infectious Diseases (NIAID)
NCT03707041 COMPLETED Safety, Tolerability and Chemoprotective Activity of P218 in PfSPZ Challenge Model
Medicines for Malaria Venture
NCT03867331 COMPLETED To Assess the Safety, Immunogenicity and Efficacy of VLPM01 in Healthy, Malaria-Naïve Volunteers
VLP Therapeutics
NCT03882528 COMPLETED Evaluate the Infectivity Equivalence of Current and New Lots of Plasmodium Falciparum Strain NF54
U.S. Army Medical Research and Development Command
NCT04289558 WITHDRAWN Nitrite Infusion in Children With Malaria
Duke University
NCT02614404 COMPLETED Effect of Imatinib on Suppression of Malaria Parasites in Patients With Uncomplicated Plasmodium Falciparum Malaria
HuLow
NCT02450578 COMPLETED DSM265 Chemoprophylaxis of Plasmodium Falciparum Malaria
Medicines for Malaria Venture
NCT03084289 COMPLETED A Study to Assess the Safety and Immunogenicity of a Candidate Malaria Vaccine Using Novel Routes of Administration
University of Oxford
NCT04130282 TERMINATED VAC077: Safety and Immunogenicity of the Pfs25-IMX313/Matrix-M Vaccine
University of Oxford
NCT02783820 COMPLETED Safety, Tolerability and Pharmacokinetic Profile of Ascending Oral Doses of MMV390048, Part A
Medicines for Malaria Venture
NCT02281344 TERMINATED MMV390048 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Participants
Medicines for Malaria Venture
NCT02431637 COMPLETED Experimental Falciparum Transmission to Anopheles
Medicines for Malaria Venture
NCT03341754 COMPLETED Trial to Evaluate the Safety, Immunogenicity, and Efficacy of Malaria Infection in Malaria Naïve Adults
U.S. Army Medical Research and Development Command
NCT02867059 COMPLETED SJ733 Induced Blood Stage Malaria Challenge Study
Medicines for Malaria Venture
NCT04002687 COMPLETED Determine the Tolerability and Safety of Atovaquone-proguanil (ATV-PG) Co-administered With Amodiaquine (AQ)
Medicines for Malaria Venture
NCT03590340 COMPLETED Regimen Optimization Trial of PfSPZ Vaccine in Equatorial Guinea
Sanaria Inc.
NCT02773979 COMPLETED PfSPZ Challenge in Healthy Malaria-Naïve Adults in the United States
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02015091 COMPLETED Study of Controlled Human Malaria Infections to Evaluate Protection After Intravenous or Intramuscular Administration of PfSPZ Vaccine in Malaria-Naive Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00889616 COMPLETED Phase I Study of the Safety and Immunogenicity of BSAM-2/Alhydrogel +CPG 7909, an Asexual Blood Stage Vaccine for Plasmodium Falciparum Malaria in Adults in the US and Mali
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01988636 COMPLETED Study of Safety and Effectiveness of Intravenous Immunization With PfSPZ Vaccine in Healthy African Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02996695 COMPLETED Safety and Efficacy of Sanaria's PfSPZ-CVac in Malian Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04069221 COMPLETED Absolute BA and OZ439 PK Effect of Different OZ439 Dose Volumes and Cobicistat Co-administration Study
Medicines for Malaria Venture
NCT02572388 COMPLETED A Study to Assess the Safety and Immunogenicity of the Malaria Vaccine, R21, Administered With and Without Matrix-M1
University of Oxford
NCT02612545 COMPLETED Efficacy, Safety, and Tolerability of Dihydroartemisinin-piperaquine + Mefloquine Compared to Dihydroartemisinin-piperaquine or Artesunate-mefloquine in Patients With Uncomplicated Falciparum Malaria in Cambodia
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01994525 COMPLETED Immunization Via Mosquito Bite With Radiation-attenuated Sporozoites
U.S. Army Medical Research and Development Command
NCT02554799 COMPLETED A Study to Evaluate the Pharmacokinetics of Oral Formulations of MMV390048 Administered Fasted to Healthy Volunteers
Medicines for Malaria Venture
NCT03435874 COMPLETED Safety and Immunogenicity of ChAd63 RH5 and MVA RH5 in Adults, Young Children and Infants Living in Tanzania
University of Oxford
NCT04072302 COMPLETED Safety and Causal Prophylactic Efficacy of KAF156 in a Controlled Human Malaria Challenge Model
Novartis Pharmaceuticals
NCT02885506 COMPLETED A FIH Study to Investigate the Safety, Tolerability and PK of P218
Medicines for Malaria Venture
NCT02663700 COMPLETED Safety and Immunogenicity of Sanaria's Irradiated Sporozoite Vaccine (PfSPZ Vaccine) in Malaria-Experienced Adults in Burkina Faso
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02543086 TERMINATED Effectiveness of KAE609 in Reducing Asexual & Sexual Blood-stage P.Falciparum Infection & Infectivity to Mosquitos
Novartis Pharmaceuticals
NCT02230579 COMPLETED Phase I Study of Ascending Doses of MMV390048 in Healthy Adult Volunteers
Medicines for Malaria Venture
NCT02858817 COMPLETED Safety and Protective Efficacy of IV Immunization With Cryopreserved PfSPZ Under A/P Chemoprophylaxis
University Hospital Tuebingen
NCT03934450 COMPLETED Metabolism and Pharmacokinetics of Primaquine Enantiomers in Human Volunteers Receiving a Seven Day Dose Regimen
University of Mississippi, Oxford
NCT02334462 COMPLETED Study of the Safety and Immunogenicity of Pfs230D1M-EPA/Alhydrogel and Pfs25M-EPA/Alhydrogel , a Transmission Blocking Vaccine Against Plasmodium Falciparum Malaria, in Adults in the U.S. and Mali
National Institute of Allergy and Infectious Diseases (NIAID)
NCT03420053 COMPLETED Study to Evaluate Safety, Immunogenicity and Efficacy of PfSPZ Vaccine in HIV Negative and HIV Positive Tanzanian Adults
Sanaria Inc.
NCT03163121 COMPLETED Safety and Protective Efficacy of Genetically Attenuated PfSPZ-GA1 Vaccine in Healthy Dutch Volunteers
Sanaria Inc.
NCT02704533 COMPLETED Sequential Optimization of Dose and Schedule of PfSPZ Vaccine
Sanaria Inc.
NCT02780154 COMPLETED PfSPZ Challenge in Non-immune Adults in Baltimore, USA
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02661373 COMPLETED First-in-Human Study of an Oral Plasmodium Falciparum Plasma Membrane Protein Inhibitor
St. Jude Children's Research Hospital
NCT02859350 COMPLETED Safety, Tolerability and Immunogenicity of PfSPZ Vaccine in an Age De-escalation Trial in Equatorial Guinea.
Sanaria Inc.
NCT02613520 COMPLETED Safety and Immunogenicity in Age De-Escalation of PfSPZ Vaccine in Tanzanian Adults, Children, and Infants
Sanaria Inc.
NCT02737007 COMPLETED A Microdose Study in Healthy Subjects to Describe Intravenous Pharmacokinetics of GSK3191607
GlaxoSmithKline
NCT00675064 COMPLETED Single-Blind, Placebo-Controlled, Randomized Study Testing Single Ascending Doses Of GSK369796 In Healthy Subjects
GlaxoSmithKline
NCT00935623 COMPLETED Clinical Trial for the Development of a Safe Malaria Challenge Model That Can be Reproduced in Humans
U.S. Army Medical Research and Development Command
NCT01949909 COMPLETED Safety And Immunogenicity Of Novel Candidate Blood-Stage Malaria Vaccine P27A : Phase Ia/Ib
Centre Hospitalier Universitaire Vaudois
NCT01867463 COMPLETED Testing Pfs25-EPA/Alhydrogel as a Potential Malaria Transmission Blocking Vaccine
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00977899 WITHDRAWN Phase 1 Study of the Safety and Immunogenicity of a Malaria Transmission-blocking Pfs25-Pfs25 Conjugate Vaccine
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT01441167 COMPLETED Experimental PfSPZ Vaccine in Adults Without Malaria
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02215707 COMPLETED A Clinical Trial of the PfSPZ Vaccine Administered by Direct Venous Inoculation in Healthy Malaria-Naïve Adults: Heterologous vs. Homologous Controlled Human Malaria Infection and Reduction in Number of Doses
Sanaria Inc.
NCT02647489 COMPLETED Safety and Immunogenicity of the Placental Malaria Vaccine Candidate PAMVAC Variously Adjuvanted
University Hospital Tuebingen
NCT02898779 COMPLETED Metabolism and Pharmacokinetics of Primaquine Enantiomers in Human Volunteers, Study 1
University of Mississippi, Oxford
NCT02658435 COMPLETED Assessment of Any Potential Retinal Effects of Tafenoquine (TQ)
GlaxoSmithKline
NCT03195387 WITHDRAWN Chemoprotective Activity of MMV390048 in PfSPZ Challenge Model
Medicines for Malaria Venture
NCT02524444 COMPLETED A Comparative Study of Mefloquine and S-P as Prophylaxis Against Malaria in Pregnant HIV + Patients
ORIYOMI OMOTOYOSI AKINYOTU
NCT02527005 COMPLETED A Comparative Study of Azithromycin and S-P as Prophylaxis in Pregnant HIV+ Patients
University of Ibadan
NCT02174978 COMPLETED Phase 1 Clinical Trial With Controlled Human Malaria Infection (CHMI) to Evaluate the Safety and Efficacy of the Plasmodium Falciparum Vaccine Candidate FMP012 Administered Intramuscularly With AS01B Adjuvant System in Healthy Malaria-Naïve Adults
U.S. Army Medical Research and Development Command
NCT00811356 TERMINATED A First Time in Human Study in Healthy Volunteers to Investigate a New Medicine to Treat Malaria
GlaxoSmithKline
NCT02532049 COMPLETED A Clinical Trial to Assess the Safety and Immunogenicity of New Malaria Vaccine Candidates ChAd63 Pfs25-IMX313 and MVA Pfs25-IMX313
University of Oxford
NCT02184637 COMPLETED A Study to Evaluate the Pharmacokinetics of a Single Dose of Tafenoquine Co-administered With Either Artemether + Lumefantrine or Dihydroartemisinin + Piperaquine Tetraphosphate
GlaxoSmithKline
NCT00740090 COMPLETED Malaria Vaccine for Children in Mali
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02511054 COMPLETED Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual B...
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02600975 COMPLETED A Study to Assess the Safety and Immunogenicity of a Malaria Vaccine Candidate, R21, Administered With AS01B
University of Oxford
NCT00871156 COMPLETED Tafenoquine/Chloroquine DDI Study
GlaxoSmithKline
NCT01928914 COMPLETED Tafenoquine Thorough QTc Study in Healthy Subjects
GlaxoSmithKline
NCT01205178 COMPLETED G6PD (Glucose-6-phosphate Dehydrogenase) Study to Evaluate Hemolysis Potential of TFQ (Tafenoquine)
GlaxoSmithKline
NCT02115516 COMPLETED Safety and Protective Efficacy of Intravenous Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chemoprophylaxis
Sanaria Inc.
NCT01728701 COMPLETED Controlled Human Malaria Infection (CHMI) After Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis
Sanaria Inc.
NCT01816113 COMPLETED Phase Ia Study of ChAd63/MVA PvDBP
University of Oxford
NCT01858831 COMPLETED Single Oral Dose Study of Atovaquone/Proguanil Hydrochloride Combination Tablets and Atovaquone Suspension
GlaxoSmithKline
NCT02013687 COMPLETED Safety and Immunogenicity of Plant-Derived Pfs25 VLP-FhCMB Malaria Transmission Blocking Vaccine in Healthy Adults
Fraunhofer, Center for Molecular Biotechnology
NCT02963324 COMPLETED Physiologically-based Pharmacokinetic Modeling of Ivermectin in Healthy Human Volunteers
University Hospital, Basel, Switzerland
NCT02751294 COMPLETED A Study to Assess the Effects of Dissolution Profile on the Pharmacokinetics of Single Oral Doses of Tafenoquine Tablets and Tafenoquine Stable Isotope Labelled Solution
GlaxoSmithKline
NCT02242799 COMPLETED Dolutegravir Interactions With Artemisinin-based Combination Therapies
University of Liverpool
NCT02132299 COMPLETED Dose Escalation, Randomized Controlled Trial to Evaluate the Safety, Immunogenicity and Efficacy of Intravenously Administered Attenuated Plasmodium Falciparum Sporozoite Vaccine (PfSPZ Vaccine) in Tanzanian Adults
Sanaria Inc.
NCT01624961 COMPLETED Controlled Human Malarial Infection by Intravenous Injection of Plasmodium Falciparum Sporozoites in Non-Immune Adults
Sanaria Inc.
NCT01771848 COMPLETED Optimization of Controlled Human Malarial Infection by Injection of P. Falciparum Sporozoites in Non-Immune Adults
Sanaria Inc.
NCT02418962 COMPLETED Safety and Immunogenicity of Direct Venous Inoculation of a Radiation-attenuated PfSPZ Vaccine in Equatoguinean Adults
Sanaria Inc.
NCT01780753 COMPLETED Primaquine Pharmacokinetics in Lactating Women and Their Infants
University of Oxford
NCT02387580 COMPLETED Bioavailability Study of Oral OZ439 Prototype Granule Formulations Administered With Piperaquine Phosphate (PQP) Tablets
Medicines for Malaria Venture
NCT02181088 COMPLETED A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of New Plasmodium Falciparum Malaria Vaccine Candidates ChAd63 RH5 Alone and With MVA RH5
University of Oxford
NCT02083887 COMPLETED A Phase I Study to Assess the Safety and Immunogenicity of ChAd63 ME-TRAP - MVA ME-TRAP Heterologous Prime-boost Vaccination Co-administered With EPI Vaccines in Gambian Infants
University of Oxford
NCT02313376 COMPLETED Safety, Attenuation and Immunogenicity of GAP3KO Administered Via A Stephensi Mosquitoes
Seattle Children's Hospital
NCT02453581 COMPLETED Effectiveness of OZ439 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Volunteers
Medicines for Malaria Venture
NCT00666380 COMPLETED A Study to Determine the Effects of an Investigational Malaria Vaccine Given to Adults Living in the United States and Thereafter to Adults Living in Kenya
U.S. Army Medical Research and Development Command
NCT01958619 COMPLETED Open Label Pharmacokinetic Study of OZ439 and Piperaquine on Administration of OZ439+TPGS Granules for Oral Suspension Alone or With Either Piperaquine Phosphate Tablets or Granules for Oral Solution in Healthy Volunteers
Medicines for Malaria Venture
NCT01853475 COMPLETED Healthy Volunteer Study of the Pharmacokinetics of Oral Piperaquine With OZ439 + TPGS Formulation in the Fasted State
Medicines for Malaria Venture
NCT01843491 WITHDRAWN A Phase I Clinical Trial Immunizing Healthy Adults With the NMRC-M3V-Ad-PfCA Vaccine to Generate Biologic Reagents
U.S. Army Medical Research and Development Command
NCT02237586 COMPLETED Effect of Plasmodium Falciparum Exposure and Sickle Cell Trait on Infection Rates and Kinetics After IV Administration of PfSPZ Challenge
Sanaria Inc.
NCT01086917 COMPLETED Experimental Human Malaria Infection by PfSPZ
Sanaria Inc.
NCT01615822 TERMINATED Safety, Tolerability & Pharmacokinetics (PK) of Co-administered Single Doses of OZ439 and Mefloquine (MQ) in Healthy Volunteers
Medicines for Malaria Venture
NCT01713608 COMPLETED A Dose-escalation Study to Investigate Safety and Toleration of OZ439
Medicines for Malaria Venture
NCT02083406 COMPLETED Bioavailability Study of Oral OZ439 Prototype Formulations Administered With Piperaquine Phosphate (PQP)
Medicines for Malaria Venture
NCT00928083 COMPLETED A Study to Investigate the Safety, Tolerability and Pharmacokinetics of OZ439 in Healthy Male and Female Subjects
Medicines for Malaria Venture
NCT01669512 COMPLETED Adjuvanting Viral Vectored Malaria Vaccines With Matrix M
University of Oxford
NCT01540903 COMPLETED Controlled Human Malaria Infection by Intradermal Injection of Plasmodium Falciparum Sporozoites in Tanzanian Adults
Sanaria Inc.
NCT01001650 COMPLETED Clinical Trial of the PfSPZ Vaccine
Sanaria Inc.
NCT00744133 COMPLETED Malaria Challenge With NF54 Strain
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01018459 COMPLETED Adenovirus Type 35 Based Circumsporozoite Malaria Vaccine in Burkina Faso
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01434381 COMPLETED Initial Study of Malaria Vaccine Pfs25-EPA/Alhydrogel(Registered Trademark)
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01450293 COMPLETED AdCh63 ME-TRAP and MVA ME-TRAP Malaria Vaccines Evaluation in Healthy Children in a Malaria Endemic Area
University of Oxford
NCT01546389 COMPLETED Sanaria™ PfSPZ Challenge Vaccine
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01364883 COMPLETED Safety and Immunogenicity of Novel Vaccination Schedules With Malaria Vaccines AdCh63 ME-TRAP and MVA ME-TRAP
University of Oxford
NCT01026246 COMPLETED EBA-175 RII-NG Malaria Vaccine Administered Intramuscularly in Semi-immune Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00513669 COMPLETED Phase Ib Trial of Two Virosome Formulated Malaria Vaccine Components (PEV 301, PEV 302) in Tanzania
Swiss Tropical & Public Health Institute
NCT01351948 COMPLETED Safety and Immunogenicity of Malaria Vaccines AdCh63 AMA1, MVA AMA1 and AMA1-C1/Alhydrogel®+/- CPG 7909
University of Oxford
NCT01373879 COMPLETED AdCh63 ME-TRAP and MVA ME-TRAP Malaria Vaccines Evaluation in Healthy Adults and Children in a Malaria Endemic Area
University of Oxford
NCT01500980 COMPLETED Malaria Challenge in Healthy Volunteers
Seattle Children's Hospital
NCT01450280 COMPLETED Safety and Immunogenicity of New Malaria Vaccine Candidate ChAd63 CS Administered Alone and With MVA CS
University of Oxford
NCT01169077 COMPLETED EP1300 Polyepitope DNA Vaccine Against Plasmodium Falciparum Malaria
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01379430 COMPLETED Safety and Immunogenicity of AdCh63 ME-TRAP and MVA ME-TRAP Vaccines in Malaria Endemic Areas
University of Oxford
NCT01218932 COMPLETED Pharmacokinetic Study of Primaquine and Chloroquine in Healthy Subjects
University of Oxford
NCT00791531 COMPLETED Assessment of Safety and Pharmacokinetics of a Low Dose of Methotrexate in Healthy Adult Male Kenyan Volunteers
KEMRI-Wellcome Trust Collaborative Research Program
NCT01103830 COMPLETED Safety Study on the Effect of Eurartesim™ on QT/QTc Interval Compared to Riamet in Healthy Volunteers
sigma-tau i.f.r. S.p.A.
NCT01095055 COMPLETED A Study of AdCh63 AMA1 Alone and With MVA AMA1
University of Oxford
NCT01222949 COMPLETED A Pharmacokinetic (PK) Trial in Healthy Asian and Caucasian Volunteers Investigating the PK Profile of Eurartesim™
sigma-tau i.f.r. S.p.A.
NCT01222962 COMPLETED Food Interaction Study on the Pharmacokinetics of Eurartesim™ (DHA and PQP)in Healthy Male Adult Volunteers
sigma-tau i.f.r. S.p.A.
NCT01100060 COMPLETED A Phase 1 Study To Estimate The Relative Bioavailability Of Co-Administered Formulations Of Azithromycin Microsphere And Chloroquine Test Formulation Compared With Co-Administered Immediate Release Individual Azithromycin And Chloroquine Tablets In Healthy Adult Subjects
Pfizer
NCT00894374 COMPLETED Bioequivalence Study Comparing Artesunate Tablet To Arsuamoon® Tablets (Guilin-China) In Healthy Subjects
Pfizer
NCT00894660 COMPLETED A Bioequivalence Study Comparing Amodiaquine Tablet (Pfizer) To Amodiaquine Tablets (Arsuamoon-Guilin China) In Healthy Subjects
Pfizer
NCT00844207 COMPLETED A Phase 1 Study To Estimate The Relative Bioavailability Of Fixed Combination Tablets Of Azithromycin And Chloroquine Compared To Co-Administered Individual Tablets Of Azithromycin And Chloroquine
Pfizer