Data updated: Jun 28, 2026
Menopause Clinical Trial Landscape
Menopause is being studied across 182 clinical trials registered since 2008, with 38 programs currently active. The competitive pipeline includes 12 active Phase 3 trials, 9 active Phase 2 trials, and 4 active Phase 1 trials.
Top industry sponsors include Bayer, Astellas, AbCellera Biologics Inc..
Trial activity
38 active / 182 total since 2008
Active by phase 12 Ph3 / 50 9 Ph2 / 59 4 Ph1 / 26 13 Ph4 / 47
Sponsor activity
Who is running trials now — green active, blue completed, red failed/terminated.
Sorted by active Active Done Failed
Bayer 1 11 0
Astellas 1 10 0
AbCellera Biologics Inc. 1 0 0
Stratpharma AG 1 0 0
Nyree Penn 1 0 0
Biolab Sanus Farmaceutica 1 0 0
Estetra 0 4 0
Depomed 0 3 0
TherapeuticsMD 0 3 0
How the field has grown
New-trial starts peaked in 2025 (17 registered). The right-hand chart shows median Phase 3 enrollment by start year — the number in parentheses is that year's Phase 3 trial count (27 in total), so single-trial years (and years with no Phase 3 starts) are obvious. Both are by trial start date; the current year is partial.
New trials started by year
2016 13
2017 13
2018 6
2019 11
2020 8
2021 11
2022 8
2023 5
2024 13
2025 17
2026 10
TheraRadar.com
Median Phase 3 enrollment by start year
2016 (2) 226
2017 (1) 55
2018 (0) 0
2019 (7) 527
2020 (2) 226
2021 (3) 400
2022 (2) 497
2023 (0) 0
2024 (6) 261
2025 (2) 93
2026 (2) 210
TheraRadar.com
Full trial pipeline
Every active and completed trial across Phase 1–4, with enrollment analytics. Sortable, filterable, exportable with Pro.
NCT05587296 ACTIVE NOT RECRUITING
A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer
Bayer n=474
NCT06975111 RECRUITING
Focusing on the Menopausal Transition to Improve Mid-Life Women's Health
University of Colorado, Denver n=200
NCT06440967 ACTIVE NOT RECRUITING
A Study to Confirm if Fezolinetant Helps Reduce Hot Flashes in Women With Breast Cancer Who Are Having Hormone Therapy
Astellas Pharma Global Development, Inc. n=982
NCT06343870 RECRUITING
Estradiol and Testosterone Subdermal Implants for Menopause Treatment (ESTIME)
University of Sao Paulo General Hospital n=140
NCT06391372 ACTIVE NOT RECRUITING
Effect of Local Estriol Treatment Before Vaginal Repair Surgery
Hatice Tukenmez Kurnaz n=36
NCT03916978 RECRUITING
Autologous PRP Intra Ovarian Infusion to Restore Ovarian Function in Menopausal Women
Genesis Athens Clinic n=100
NCT04031456 RECRUITING
Autologous PRP Infusion May Restore Ovarian Function and May Promote Folliculogenesis in POI Patients
Genesis Athens Clinic n=100
NCT06564883 NOT YET RECRUITING
Hydration and Acceptability of the Genital and Skin Mucosa of a Vaginal Moisturizer in Menopausal Women
Biolab Sanus Farmaceutica n=45
NCT06530459 RECRUITING
The MUSE Study for Menopausal Arthralgia
National University Hospital, Singapore n=100
NCT06514586 NOT YET RECRUITING
The Efficacy of Topical Vaginal Oxytocin Gel in Postmenopausal Women With Vulvovaginal Atrophy
Oxagon n=244
NCT05586724 RECRUITING
Micronized Progesterone Versus Norethisterone Acetate in Combination With Estrogen as Menopausal Hormone Therapy
Angelica Lindén Hirschberg n=520
NCT07606664 NOT YET RECRUITING
Fezolinetant and Vascular Health and Brain Health
Rebecca Thurston n=220
NCT06206421 COMPLETED
A Study to Assess Long-term Safety of Fezolinetant Given to Japanese Women Going Through Menopause
Astellas Pharma Inc n=277
NCT05099159 COMPLETED
A Study to Learn More About How Well Elinzanetant Works and How Safe it is for the Treatment of Vasomotor Symptoms (Hot Flashes) That Are Caused by Hormonal Changes Over 26 Weeks in Women Who Have Been Through the Menopause (OASIS-2)
Bayer n=400
NCT05042362 COMPLETED
A Study to Learn More About How Well Elinzanetant Works and How Safe it is for the Treatment of Vasomotor Symptoms (Hot Flashes) That Are Caused by Hormonal Changes Over 26 Weeks in Women Who Have Been Through the Menopause
Bayer n=396
NCT04090957 COMPLETED
Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women (E4Comfort II)
Estetra n=1,015
NCT06206408 COMPLETED
A Study to Confirm if Fezolinetant Helps Reduce Hot Flashes in Japanese Women Going Through Menopause
Astellas Pharma Inc n=410
NCT05030584 COMPLETED
A Study to Learn More About How Well Elinzanetant Works and How Safe it is for the Treatment of Vasomotor Symptoms (Hot Flashes) That Are Caused by Hormonal Changes Over 52 Weeks in Women Who Have Been Through the Menopause
Bayer n=628
NCT04451226 COMPLETED
A Study to Assess the Safety and Tolerability of Fezolinetant in Women Seeking Treatment for Relief of Vasomotor Symptoms (VMS) Associated With Menopause
Astellas Pharma China, Inc. n=150
NCT04234204 COMPLETED
A Study to Find Out if Fezolinetant Helps Reduce Moderate to Severe Hot Flashes in Women in Asia Going Through Menopause
Astellas Pharma China, Inc. n=302
NCT04209543 COMPLETED
Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women (E4Comfort Study I)
Estetra n=1,570
NCT01573442 COMPLETED
Testosterone in Treating Postmenopausal Patients With Arthralgia Caused by Adjuvant Aromatase Inhibitor Treatment
Alliance for Clinical Trials in Oncology n=227
NCT04003142 COMPLETED
A Study to Find Out if Fezolinetant Helps Reduce Moderate to Severe Hot Flashes in Women Going Through Menopause - 2
Astellas Pharma Global Development, Inc. n=501
NCT04003389 COMPLETED
A Study to Find Out How Safe Long-term Treatment With Fezolinetant is in Women With Hot Flashes Going Through Menopause
Astellas Pharma Global Development, Inc. n=1,831
NCT04003155 COMPLETED
A Study to Find Out if Fezolinetant Helps Reduce Moderate to Severe Hot Flashes in Women Going Through Menopause
Astellas Pharma Global Development, Inc. n=527
NCT03854396 WITHDRAWN
Clinical Trial on the Preventive Effect of Intravaginal Prasterone on Recurrent Urinary Tract Infections in Postmenopausal Women
Olivia Cardenas-Trowers, M.D.
NCT01080300 COMPLETED
Breeze3:Study of Gabapentin Extended Release in the Treatment of Vasomotor Symptoms(Hot Flashes)in Postmenopausal Women
Depomed n=600
NCT02224313 COMPLETED
Effect of Oral Estradiol and Progesterone Therapy on Vaginal Cytokines in Postmenopausal Women
Intira Sriprasert n=20
NCT02961790 COMPLETED
Oxybutynin Chloride in Managing Hot Flashes
Academic and Community Cancer Research United n=150
NCT01942668 COMPLETED
A Safety and Efficacy Study of the Combination Estradiol and Progesterone to Treat Vasomotor Symptoms
TherapeuticsMD n=1,845
NCT01805765 COMPLETED
Qing'E Formula Therapy on Menopausal Symptoms
Shanghai University of Traditional Chinese Medicine n=240
NCT03202186 TERMINATED
Study of Progesterone in Treatment of Vasomotor Symptoms
BHR Pharma, LLC n=55
NCT02749747 COMPLETED
Sulpiride Versus Placebo for Reducting Hot Flushes During Climacteric
Hospital de Clinicas de Porto Alegre n=28
NCT00697463 COMPLETED
Forteo for the Treatment of Unexplained Osteoporosis in Premenopausal Women
Columbia University n=22
NCT01308814 COMPLETED
Perimenopausal Estrogen Replacement Therapy Study
University of North Carolina, Chapel Hill n=172
NCT02253173 COMPLETED
Estradiol Vaginal Softgel Capsules in Treating Symptoms of Vulvar and Vaginal Atrophy in Postmenopausal Women
TherapeuticsMD n=764
NCT01539317 COMPLETED
Therapy to Prevent Sexual Pain in Breast Cancer Survivors
OHSU Knight Cancer Institute n=50
NCT00956813 COMPLETED
Flaxseed in Treating Postmenopausal Women With Hot Flashes Who Have a History of Breast Cancer or Other Cancer or Who Do Not Wish to Take Estrogen Therapy
Alliance for Clinical Trials in Oncology n=210
NCT02497560 TERMINATED
A Study To Investigate The Effect Of A Natural Dietary Supplement On Peri-Menopausal Symptoms
Physician Recommended Nutriceuticals n=20
NCT00702949 COMPLETED
Pregabalin in Treating Women With Hot Flashes
Alliance for Clinical Trials in Oncology n=207
NCT01101841 COMPLETED
24-Week Efficacy & Safety Study of Brisdelle™ (Formerly Known as Mesafem) in the Treatment of Vasomotor Symptoms
Noven Therapeutics n=570
NCT01779947 COMPLETED
Study to Evaluate the Safety and Bioequivalence of Estradiol Vaginal Inserts, 10 mcg and Vagifem® 10 mcg and Compare to Placebo
Amneal Pharmaceuticals, LLC n=519
NCT00808132 COMPLETED
Study Evaluating The Effects Of Bazedoxifene/Conjugated Estrogens On Endometrial Safety And Postmenopausal Osteoporosis
Pfizer n=1,886
NCT00859703 COMPLETED
Study to Assess Efficacy of Risedronate in Preventing Bone Loss in Postmenopausal Women Treated for Breast Cancer
Hospices Civils de Lyon n=20
NCT00711529 COMPLETED
Pilot Study Comparing Hypnotherapy and Gabapentin for Hot Flashes.
Women and Infants Hospital of Rhode Island n=27
NCT00755417 COMPLETED
Study of Gabapentin Extended Release (G-ER) in the Treatment of Vasomotor (Hot Flashes/Hot Flushes) Symptoms in Postmenopausal Women
Depomed n=541
NCT00777023 COMPLETED
Study of Gabapentin Extended Release (G-ER)in the Treatment of Vasomotor (Hot Flashes/Hot Flushes) Symptoms in Postmenopausal Women.
Depomed n=565
NCT01429636 COMPLETED
Applied Relaxation (AR) Technique Versus Its Modified Version for Treating Menopausal Symptoms
Chiang Mai University n=60
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only