Data updated: Jun 28, 2026
Nausea/Vomiting Clinical Trial Landscape
Nausea/Vomiting is being studied across 386 clinical trials registered since 2008, with 46 programs currently active. The competitive pipeline includes 14 active Phase 3 trials, 13 active Phase 2 trials, and 1 active Phase 1 trials.
Top industry sponsors include Helsinn Healthcare SA, Eli Lilly, Vanda Pharmaceuticals.
Trial activity
46 active / 386 total since 2008
Active by phase 14 Ph3 / 119 13 Ph2 / 99 1 Ph1 / 33 18 Ph4 / 135
Sponsor activity
Who is running trials now — green active, blue completed, red failed/terminated.
Sorted by active Active Done Failed
Helsinn Healthcare SA 1 11 0
Eli Lilly 1 0 0
Vanda Pharmaceuticals 1 0 0
CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. 1 0 0
Merck 0 11 3
Acacia Pharma Ltd 0 9 0
Tesaro, Inc. 0 6 0
Charleston Laboratories, Inc 0 5 0
Fujian Shengdi Pharmaceutical Co., Ltd. 0 4 0
GSK 0 2 1
Forest Laboratories 0 3 0
How the field has grown
New-trial starts peaked in 2025 (29 registered). The right-hand chart shows median Phase 3 enrollment by start year — the number in parentheses is that year's Phase 3 trial count (56 in total), so single-trial years (and years with no Phase 3 starts) are obvious. Both are by trial start date; the current year is partial.
New trials started by year
2016 19
2017 22
2018 15
2019 18
2020 21
2021 15
2022 23
2023 13
2024 20
2025 29
2026 9
TheraRadar.com
Median Phase 3 enrollment by start year
2016 (4) 327
2017 (5) 240
2018 (3) 120
2019 (3) 109
2020 (5) 91
2021 (5) 60
2022 (8) 100
2023 (4) 110
2024 (11) 370
2025 (5) 100
2026 (3) 260
TheraRadar.com
Full trial pipeline
Every active and completed trial across Phase 1–4, with enrollment analytics. Sortable, filterable, exportable with Pro.
NCT07208305 RECRUITING
Olanzapine Plus Metoclopramide for the Prevention of Opioid-Induced Nausea and Vomiting
Affiliated Hospital of Qinghai University n=222
NCT07446439 RECRUITING
A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use
Vanda Pharmaceuticals n=280
NCT01696734 RECRUITING
Domperidone in Treating Patients With Gastrointestinal Disorders
M.D. Anderson Cancer Center n=200
NCT07248280 RECRUITING
Adding Aprepitant to a Multimodal Strategy for the Prevention of Postoperative Nausea and Vomiting in High-risk Outpatient Surgical Patients
Centre hospitalier de l'Université de Montréal (CHUM) n=260
NCT05418244 RECRUITING
Inhaled Isopropyl Alcohol for Treatment of Nausea
State University of New York at Buffalo n=84
NCT06382012 RECRUITING
Antiemetic Fosaprepitant To Remedy Nausea and Vomiting
Montefiore Medical Center n=200
NCT07035821 NOT YET RECRUITING
Olanzapine for Prevention of Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy
Shanghai Children's Medical Center n=100
NCT06200168 RECRUITING
Electroacupuncture for the Prevention of Chemotherapy-induced Nausea and Vomiting in Patients With Breast Cancer
Jiuda Zhao n=370
NCT06850454 RECRUITING
Olanzapine Versus Placebo for Moderately Emetogenic Chemotherapy
Mahidol University n=140
NCT06585540 RECRUITING
A Pilot Study to Evaluate Barhemsys for the Prevention of Postoperative Nausea And Vomiting in the Bariatric Surgery Population
Benaroya Research Institute n=100
NCT05120076 RECRUITING
Perioperative Dexamethasone Reduces Postoperative Pain and Nausea After Periacetabular Osteotomy
Balgrist University Hospital n=60
NCT06543966 NOT YET RECRUITING
Efficacy and Safety Study of Aprepitant Injection for Prevention of Post-operative Nausea and Vomiting
CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. n=486
NCT06314906 RECRUITING
Electroacupuncture Plus Antiemetic Therapy for Chemotherapy-Induced Nausea and Vomiting in Patients With Breast Cancer
Feixue Song n=370
NCT06017284 RECRUITING
Thalidomide to Chemotherapy Related Nausea and Vomiting in Pancreatic Cancer
Fudan University n=100
NCT02466984 COMPLETED
Subcutaneous Route and Pharmacology of Metoclopramide
University Hospital, Bordeaux n=5
NCT06331520 COMPLETED
NEPA Combined With Olanzapine, Dexamethasone-sparing for the Effect of CINV in Patients Receiving HEC Regimens
Fudan University n=644
NCT02106494 COMPLETED
A Prospective, Multicenter, Study of APF530 (Granisetron) SC for Prevention of CINV in Patients Receiving HEC
Heron Therapeutics n=942
NCT07426081 COMPLETED
Comparison of Dexmedetomidine and Dexamethasone for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy
Patel Hospital, Pakistan n=68
NCT07081256 COMPLETED
To Evaluate the Efficacy and Safety of QLM2010 for Prevention of Chemotherapy-induced Nausea and Vomiting After Highly Emetogenic Chemotherapy.
Qilu Pharmaceutical Co., Ltd. n=665
NCT06554184 COMPLETED
HR20013 for Nausea and Vomiting Associated With Moderate Emetic Risk Anticancer Agents
Fujian Shengdi Pharmaceutical Co., Ltd. n=706
NCT07140341 COMPLETED
A Clinical Study to Assess the Effectiveness of ENO Lime in Participants With Ajeerna Vyadhi (Acidity, Acid Indigestion, Indigestion, and Associated Nausea)
HALEON n=40
NCT05546359 COMPLETED
Study of Intravenous Amisulpride for Prophylaxis of Post-operative Nausea and Vomiting (PONV) in Pediatric Patients
Acacia Pharma Ltd n=453
NCT05988671 COMPLETED
Intraperitoneal Dexamethasone, Dexmedetomidine, and Dexamethasone-Dexmedetomidine Combination on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy
Al-Azhar University n=120
NCT05805800 COMPLETED
Olanzapine and 5-HT3 With or Without Dexamethasone to Prevent CINV
Xingchen Peng n=275
NCT05065567 TERMINATED
Haloperidol, Droperidol, Ondansetron in Cannabis Hyperemesis
Corewell Health South n=32
NCT03851835 COMPLETED
Multi-DOSE Oral Ondansetron for Pediatric Acute GastroEnteritis
University of Calgary n=1,030
NCT06932107 COMPLETED
Efficacy and Safety Study of Aprepitant Injection for Prevention of Post-operative Nausea and Vomiting
Qilu Pharmaceutical (Hainan) Co., Ltd. n=518
NCT05516953 COMPLETED
Baclofen in Preventing Postoperative Nausea and Vomiting After Bariatric Surgery
Tanta University n=100
NCT05620641 COMPLETED
Ondansetron and Gabapentin in Preventing Postoperative Nausea and Vomiting After Laparoscopic Sleeve Gastrectomy
Tanta University n=100
NCT03984214 COMPLETED
Efficacy and Safety of Dronabinol in the Improvement of Chemotherapy-induced and Tumor-related Symptoms in Advanced Pancreatic Cancer
Arbeitsgemeinschaft medikamentoese Tumortherapie n=109
NCT06847594 COMPLETED
An Evaluation the Effect of Superhydration Versus Dextrose 10% for Prevention of Post Operative Nausea and Vomiting After Laparoscopic Cholecystectomy (Prospective Randomised Controlled Study)
Ain Shams University n=204
NCT02116530 COMPLETED
Antiemetic Therapy With or Without Olanzapine in Preventing Chemotherapy-Induced Nausea and Vomiting in Patients With Cancer Receiving Highly Emetogenic Chemotherapy
Alliance for Clinical Trials in Oncology n=401
NCT02939287 COMPLETED
Aprepitant- and Olanzapine- Containing Anti-emetic Regimens With High Dose Melphalan
Rush University Medical Center n=52
NCT05242874 COMPLETED
Anti-emetic Prophylaxis With or Without Dexamethasone
Henan Cancer Hospital n=442
NCT06531603 COMPLETED
Postoperative Analgesic Effectiveness of Bupivacaine With and Without Dexmedetomidine in Patients With Abdominal Surgery
Sahiwal medical college sahiwal n=64
NCT06390787 COMPLETED
The Efficacy of B6 and Metoclopramide Combination in Comparison With the Other Antiemetics
University of Baghdad n=250
NCT03874936 COMPLETED
The Effect of Perioperative Dexamethasone Administration on Postoperative Pain in Patients Undergoing Periacetabular Osteotomy.
Odense University Hospital n=90
NCT00701909 COMPLETED
Pain Medicine for Wound Care Procedures
University of California, San Francisco n=12
NCT05564286 COMPLETED
Triple Antiemetic Regimen for Chemoradiotherapy in Cervical Cancer or Nasopharyngeal Cancer
Shantou University Medical College n=116
NCT05998317 COMPLETED
Dexamethasone at Night vs at Induction on PONV After Laparoscopic Cholecystectomy
Mansoura University n=60
NCT05509634 COMPLETED
Clinical Study of HR20013 for Injection in Patients With Malignant Solid Tumors
Fujian Shengdi Pharmaceutical Co., Ltd. n=754
NCT03040726 COMPLETED
Netupitant and Palonosetron Hydrochloride in Preventing Chronic Nausea and Vomiting in Patients With Cancer
M.D. Anderson Cancer Center n=53
NCT04610398 COMPLETED
Perioperative Dexamethasone Reduces Postoperative Pain and Nausea After Hip Arthroscopy
Balgrist University Hospital n=60
NCT04535141 COMPLETED
Olanzapine for Nausea/Vomiting Prophylaxis in Recipients of Hematopoietic Stem Cell Transplants
UNC Lineberger Comprehensive Cancer Center n=91
NCT01937156 COMPLETED
A Randomized Controlled Trial of SP-01 (Granisetron Transdermal Delivery System) in Chemotherapy-induced Nausea and Vomiting
Solasia Pharma K.K. n=313
NCT03657810 COMPLETED
A Controlled Study to Determine the Efficacy and Safety of CL-108 5 mg for Acute Pain and the Prevention of OINV
Charleston Laboratories, Inc n=349
NCT03674294 COMPLETED
Aprepitant Triple Therapy for the Prevention of CINV in Nondrinking and Young Women Who Received Moderately Emetogenic Chemotherapy
Sun Yat-sen University n=248
NCT05658406 COMPLETED
Supplemental Perioperative Intravenous Crystalloids for Postoperative Nausea and Vomiting in Children Undergoing Oncological Surgery
Alexandria University n=100
NCT04437017 COMPLETED
Olanzapine or Dexamethasone, With 5-HT3 RA and NK-1 RA, to Prevent CINV
Fifth Affiliated Hospital, Sun Yat-Sen University n=557
NCT04401384 COMPLETED
Effectiveness of Acupuncture and Doxylamine/Pyridoxine for Moderate to Severe Nausea and Vomiting in Pregnancy
Xiaoke Wu n=352
NCT04232423 COMPLETED
Olanzapine for Chemotherapy-induced Nausea and Vomiting Prophylaxis
Department of Medical Services Ministry of Public Health of Thailand n=90
NCT03631004 COMPLETED
Pre-operative Olanzapine as Prophylactic Antiemetic in Oncologic Patients
Instituto do Cancer do Estado de São Paulo n=100
NCT00614445 COMPLETED
The Efficacy Of Diclectin® For Nausea And Vomiting Of Pregnancy
Duchesnay Inc. n=280
NCT05087615 COMPLETED
Effects of Ondansetron, Metoclopramide and Granisetron on Perioperative Nausea and Vomiting in Patients Undergone Bariatric Surgery
Shahid Beheshti University of Medical Sciences n=130
NCT01363479 COMPLETED
An Efficacy and Safety Study of Oral and Intravenous Palonosetron for the Prevention of Nausea and Vomiting
Helsinn Healthcare SA n=743
NCT01733212 COMPLETED
Efficacy of Ginger on Intraoperative and Postoperative Nausea and Vomiting in Elective Cesarean Section Patients
Joel Yarmush n=239
NCT02909478 COMPLETED
Aprepitant Without Steroid in Preventing Chemotherapy-induced Nausea and Vomiting in Patients With Colorectal Cancer
Sun Yat-sen University n=315
NCT04613726 COMPLETED
The Effect of Intravenous Granisetron and Ondansetron in Patients Undergoing Cesarean Section
Ataturk University n=120
NCT00553059 COMPLETED
Palonosetron and Dexamethasone With or Without Dronabinol in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy For Cancer
M.D. Anderson Cancer Center n=62
NCT04075955 COMPLETED
Feasibility of Olanzapine at REduced doSe in hIGHly Emetogenic chemoTherapy
CR-CSSS Champlain-Charles-Le Moyne n=30
NCT03403712 COMPLETED
A Study to Assess the Safety and the Efficacy of IV Fosnetupitant/Palonosetron (260 mg/0.25 mg) Combination Compared to Oral Netupitant/Palonosetron (300 mg/0.5 mg) Combination for the Prevention of CINV in AC Chemotherapy in Women With Breast Cancer
Helsinn Healthcare SA n=404
NCT02161705 TERMINATED
Pre-op Paravertebral Blocks to Decrease Post-op Pain Following Mastectomy With Immediate Tissue Expander (TE) Reconstruction
Johns Hopkins University n=18
NCT02102555 TERMINATED
Acetaminophen vs Placebo in the Pre-operative Setting and Outcomes on Post-operative Pain, Nausea and Vomiting
MercyOne Des Moines Medical Center n=82
NCT02400047 COMPLETED
Dexamethasone, Can it Replace Ketoprofen in the Strategy of Intraoperative Multimodal Analgesia in Paediatric Surgery ? A Prospective Randomized Double-blinded Study. DEXA OP
Rennes University Hospital n=580
NCT04140058 COMPLETED
Hemodynamic Protection of Preoperative Ondansetron 15 Minutes Before Spinal Anaesthesia in Caesarean Section
University of Jordan n=151
NCT03219710 COMPLETED
"Olanzapine for Prevention of Chemotherapy Induced Nausea and Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy (HEC)"
All India Institute of Medical Sciences n=240
NCT02519842 TERMINATED
Efficacy and Safety Study of Fosaprepitant (MK-0517) Plus Ondansetron Versus Ondansetron Alone for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Pediatric Participants (MK-0517-044)
Merck Sharp & Dohme LLC n=75
NCT02449291 COMPLETED
Study of APD421 as PONV Treatment (no Prior Prophylaxis)
Acacia Pharma Ltd n=568
NCT01362530 COMPLETED
A Study of the Safety and Efficacy of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Pediatric Participants (MK-0869-208)
Merck Sharp & Dohme LLC n=307
NCT01594749 COMPLETED
Efficacy and Safety of Fosaprepitant Dimeglumine in Preventing Chemotherapy-Induced Nausea and Vomiting (MK-0517-031)
Merck Sharp & Dohme LLC n=1,015
NCT02666014 COMPLETED
Sugammadex Versus Neostigmine for Postoperative Nausea and Vomiting After Laparoscopic Gynaecological Surgery
KK Women's and Children's Hospital n=184
NCT02557035 COMPLETED
An Efficacy and Safety Study of Intravenous Palonosetron Administered as an Infusion and as a Bolus for the Prevention of Nausea and Vomiting
Helsinn Healthcare SA n=441
NCT02517021 COMPLETED
A Safety Study of Intravenous Pro-Netupitant and Palonosetron Combination for the Prevention of Nausea and Vomiting
Helsinn Healthcare SA n=405
NCT00601172 COMPLETED
A Study Of IV Casopitant For The Prevention Of Chemotherapy Induced Nausea And Vomiting.
GlaxoSmithKline n=710
NCT00952341 COMPLETED
Aprepitant/MK0869 for Prevention of Chemotherapy Induced Nausea and Vomiting Associated With Cisplatin (0869-169)(COMPLETED)
Merck Sharp & Dohme LLC n=421
NCT02484911 COMPLETED
Aprepitant ,Olanzapine,Palonosetron and Dexamethasone for the Prevention of Chemotherapy-induced Nausea and Vomiting
First Affiliated Hospital of Harbin Medical University n=120
NCT02109640 COMPLETED
A Comparison of Targinact vs. Oxycodone on Gut Function After Colorectal Surgery
University of Edinburgh n=50
NCT00619359 COMPLETED
Evaluation of Fosaprepitant (MK0517) in Single Dose Schedule (0517-017)
Merck Sharp & Dohme LLC n=2,322
NCT02744495 COMPLETED
Prophylaxis of Postoperative Nausea and Vomiting After Cardiac Surgery
Hôpital Privé de Parly II - Le Chesnay n=502
NCT02462811 COMPLETED
A Double-Blind, Randomized, Active- and Placebo-Controlled, Multiple-Dose Multi-Center Phase 3 Study of the Safety and Efficacy of CL-108 in the Treatment of Moderate to Severe Acute Pain and Opioid-Induced Nausea and Vomiting (OINV)
Joseph Hazelton n=552
NCT01780428 COMPLETED
Phase III Study of the Safety and Efficacy of Cl-108 in the Treatment of Moderate to Severe Pain
Charleston Laboratories, Inc n=460
NCT02462850 COMPLETED
A Multi-Center Actual-Use Study on the Safety of CL 108 for the Treatment of Moderate to Severe Acute Pain Associated With Osteoarthritis of the Knee or Hip
Charleston Laboratories, Inc n=178
NCT02830906 COMPLETED
Effect of Ramosetron in Prevention of Intrathecal Morphine Induced Nausea and Vomiting
Thammasat University n=99
NCT00880191 COMPLETED
Gabapentin in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy
Alliance for Clinical Trials in Oncology n=430
NCT01499849 COMPLETED
Ph3 Safety/Efficacy Study of Rolapitant for the Prevention of CINV in Subjects Receiving Highly Emetogenic Chemotherapy
Tesaro, Inc. n=532
NCT02506855 WITHDRAWN
Intraoperative Transversus Abdominis Plane Block for Gynecologic Surgery (GYNTAP)
University of Mississippi Medical Center
NCT01135550 TERMINATED
Low Dose Versus Usual Dose Dexamethasone for Symptom Control in Children Undergoing Cranial or Craniospinal Radiation
The Hospital for Sick Children n=25
NCT02525848 COMPLETED
Aprepitant Versus Gabapentin Prophylaxis for Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgeries
Assiut University n=150
NCT01500226 COMPLETED
Ph 3 Safety/Efficacy Study of Rolapitant for Prevention of CINV in Subjects Receiving Moderately Emetogenic Chemotherapy
Tesaro, Inc. n=1,369
NCT01500213 COMPLETED
Ph3 Safety/Efficacy Study of Rolapitant for the Prevention of CINV in Subjects Receiving Highly Emetogenic Chemotherapy
Tesaro, Inc. n=555
NCT02384187 COMPLETED
Gabapentin Premedication and Adenotonsillectomy in Pediatric Patients
Cairo University n=140
NCT02331563 WITHDRAWN
Adjuvant Effect of Dexmedetomidine in Ultrasound (USG) Guided Transvers Abdominis Plane Block
Kırıkkale University
NCT01074697 COMPLETED
Efficacy of Two Antiemetic Regimens in Patients Receiving Radiotherapy and Concomitant Weekly Cisplatin
Odense University Hospital n=246
NCT00891761 WITHDRAWN
A Study of IV Casopitant for the Prevention of Nausea and Vomiting Caused By Cisplatin-Based Highly Emetogenic Chemotherapy
GlaxoSmithKline
NCT00828295 COMPLETED
Safety and Efficacy of Palonosetron IV to Prevent Postoperative Nausea and Vomiting in Pediatric Patients
Helsinn Healthcare SA n=150
NCT01402024 COMPLETED
Study to Evaluate Anti-emetic Effect of Aprepitant Versus Placebo in Children and Adolescent Receiving Chemotherapy
All India Institute of Medical Sciences n=96
NCT02028910 TERMINATED
Efficacy of Ondansetron on Vomiting Due to Acute Gastroenteritis in Pediatric During Winter
Assistance Publique - Hôpitaux de Paris n=20
NCT01339260 COMPLETED
An Efficacy and Safety Study of Oral Netupitant and Palonosetron for the Prevention of Nausea and Vomiting
Helsinn Healthcare SA n=1,455
NCT01376297 COMPLETED
A Safety Study of Oral Netupitant and Palonosetron for the Prevention of Nausea and Vomiting
Helsinn Healthcare SA n=413
NCT01442376 COMPLETED
Efficacy and Safety of Palonosetron Intravenous in Prevention of Chemotherapy Induced Nausea and Vomiting in Pediatric Patients
Helsinn Healthcare SA n=502
NCT01395901 COMPLETED
Safety and Efficacy of Palonosetron IV to Prevent Postoperative Nausea and Vomiting in Pediatric Patients
Helsinn Healthcare SA n=670
NCT01531218 COMPLETED
Trial Of Azithromycin In Campylobacter Concisus Patients With Diarrhea
University of Aarhus n=100
NCT01052844 COMPLETED
Gabapentin in the Prevention of Nausea and Vomiting Induced by Chemotherapy
Faculdade de Medicina do ABC n=80
NCT01617837 COMPLETED
The Efficacy of P6 Acupressure in Reducing Postoperative Nausea and Vomiting in Patients Undergoing Craniotomy
Umeå University n=80
NCT00978185 COMPLETED
Acupressure Wristbands or Standard Care in Controlling Nausea Caused by Chemotherapy
University of Manchester n=699
NCT00978549 COMPLETED
Symptom Control With or Without Docetaxel in Treating Patients With Relapsed Esophageal Cancer or Stomach Cancer
Cambridge University Hospitals NHS Foundation Trust n=320
NCT01629992 COMPLETED
Preoperative Counseling in Cholecystectomy
Federal University of Mato Grosso n=119
NCT01575600 COMPLETED
Effect of Intravenous Fluid Therapy on Postoperative Vomiting in Children Undergoing Otorhinolaryngological Surgery
Ignacio Cortínez F. n=100
NCT01502969 COMPLETED
Safety and Immunogenicity Assessment of Rotavin-M1 in Vietnamese Children
National Institute of Hygiene and Epidemiology, Vietnam n=799
NCT01297010 COMPLETED
Dexamethasone Compared to Ondansetron and Dexamethasone for Prophylaxis of Postoperative Vomiting in Children
Instituto Materno Infantil Prof. Fernando Figueira n=134
NCT01122459 COMPLETED
Evaluation of the Effect of Two Types of Fluid in the Recovery From Anaesthesia. Voluven 6% v Hartmanns
The Rotunda Hospital n=120
NCT00971399 COMPLETED
Ramosetron Versus Ondansetron for Radiotherapy Induced Nausea and Vomiting
Seoul National University Hospital n=172
NCT01116713 COMPLETED
Effect of Dexamethasone in Postoperative Symptoms After Mastectomy for Breast Cancer
Instituto Mexicano del Seguro Social n=70
NCT00965367 COMPLETED
Postoperative Nausea and Vomiting and Acupuncture/Acupressure
National Research Centre of Complementary and Alternative Medicine, Norway n=154
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only