Data updated: Jun 28, 2026
Neuropathic Pain Clinical Trial Landscape
Neuropathic Pain is being studied across 320 clinical trials registered since 2008, with 69 programs currently active. The competitive pipeline includes 14 active Phase 3 trials, 31 active Phase 2 trials, and 12 active Phase 1 trials.
Top industry sponsors include Vertex Pharmaceuticals Incorporated, Eli Lilly, Haisco Pharmaceutical Group Co., Ltd..
Trial activity
69 active / 320 total since 2008
Active by phase 14 Ph3 / 55 31 Ph2 / 159 12 Ph1 / 48 12 Ph4 / 58
Sponsor activity
Who is running trials now — green active, blue completed, red failed/terminated.
Sorted by active Active Done Failed
Vertex Pharmaceuticals Incorporated 4 0 0
Eli Lilly 3 4 1
Haisco Pharmaceutical Group Co., Ltd. 2 3 0
iN Therapeutics Co., Ltd. 1 1 0
Neurodawn Pharmaceutical Co., Ltd. 1 0 0
Syqe Medical 1 0 0
Sangamo Therapeutics 1 0 0
Shandong Suncadia Medicine Co., Ltd. 1 0 0
Ono Pharmaceutical Co., Ltd. 1 0 0
EicOsis Human Health Inc. 1 0 0
Noema Pharma AG 1 0 0
Alcamena Stem Cell Therapeutics 1 0 0
Dogwood Therapeutics Inc. 1 0 0
Egyptian International Pharmaceutical Industries Co 1 0 0
Shanghai Yidian Pharmaceutical Technology Development Co., Ltd. 1 0 0
How the field has grown
New-trial starts peaked in 2024 (24 registered); 2025 saw 19. The right-hand chart shows median Phase 3 enrollment by start year — the number in parentheses is that year's Phase 3 trial count (28 in total), so single-trial years (and years with no Phase 3 starts) are obvious. Both are by trial start date; the current year is partial.
New trials started by year
2016 14
2017 11
2018 4
2019 16
2020 21
2021 10
2022 15
2023 21
2024 24
2025 19
2026 17
TheraRadar.com
Median Phase 3 enrollment by start year
2016 (0) 0
2017 (2) 187
2018 (0) 0
2019 (3) 300
2020 (0) 0
2021 (3) 372
2022 (4) 138
2023 (7) 60
2024 (4) 432
2025 (3) 148
2026 (2) 65
TheraRadar.com
Full trial pipeline
Every active and completed trial across Phase 1–4, with enrollment analytics. Sortable, filterable, exportable with Pro.
NCT07231419 RECRUITING
Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy
Vertex Pharmaceuticals Incorporated n=734
NCT06628908 RECRUITING
Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy
Vertex Pharmaceuticals Incorporated n=1,100
NCT02219373 NOT YET RECRUITING
Gabapentin and Oxcarbazepine for Chronic Neuropathic Pain in Children and Adolescents: A Clinical Effectiveness Study
Boston Children's Hospital n=60
NCT06023706 RECRUITING
Study Evaluating the Analgesic Efficacy of Capsaicin 8% Patches in Chronic Coccygodynia.
Nantes University Hospital n=188
NCT06696443 ACTIVE NOT RECRUITING
Evaluation of the Long-term Safety and Effectiveness of Suzetrigine (SUZ) in Participants With Painful Diabetic Peripheral Neuropathy (DPN)
Vertex Pharmaceuticals Incorporated n=455
NCT05217628 ACTIVE NOT RECRUITING
An Efficacy and Safety Study of Basimglurant (NOE-101) in Patients With Trigeminal Neuralgia.
Noema Pharma AG n=166
NCT05997979 RECRUITING
Analgesic Effectiveness of Capsaicin 8% Cutaneous Patch in Children
University Hospital, Brest n=46
NCT07084285 NOT YET RECRUITING
Cervical Facet Injection of Corticosteroids for the Management of Cervicobrachialgia
Assistance Publique - Hôpitaux de Paris n=70
NCT06872437 RECRUITING
Evaluation of the Efficacy of Therapeutic Infiltrations of the Pudendal Nerve, Performed Under Neurostimulation on Pain, 1 Month After an Infiltration of Local Anaesthetic, in the Treatment of Pudendal Neuralgia.
Groupe Hospitalier Diaconesses Croix Saint-Simon n=60
NCT06937385 NOT YET RECRUITING
0.5% Bupivacaine Lower Cervical Intramuscular Injection vs IV Medications for Headache Treatment
HCA Florida North Florida Hospital n=100
NCT04666714 RECRUITING
Efficacy and Safety of Praga Formulation in the Treatment of Neuropathic Pain
EMS n=136
NCT06422117 NOT YET RECRUITING
Efficacy and Safety of HSK16149 Capsule in the Treatment of Moderate and Severe Central Neuropathic Pain in China
Haisco Pharmaceutical Group Co., Ltd. n=408
NCT05196503 RECRUITING
Efficacy of an Intraoperative Periradicular Application of Platelet Rich Fibrin (PRF) on the Intensity of Residual Post-surgical Neuropathic Pain After a Surgery for Disc Herniation
University Hospital, Strasbourg, France n=60
NCT04967664 COMPLETED
Comparison of Qutenza (8% Capsaicin) With a Low-dose Capsaicin for Treatment of Nerve Pain After Surgery
Averitas Pharma, Inc. n=409
NCT05639946 COMPLETED
Brivaracetam to Reduce Neuropathic Pain in Chronic SCI: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
University of Minnesota n=44
NCT07349680 COMPLETED
Ultrasound-Guided Thoracic Paravertebral Block With Steroid and Local Anesthetic for Acute Herpes Zoster: Effects on Pain Control and Prevention of Postherpetic Neuralgia
Assiut University n=100
NCT05890053 COMPLETED
To Evaluate the Long-term Safety and Efficacy of HSK16149 in Chinese Patients With Peripheral Neuralgia
Haisco Pharmaceutical Group Co., Ltd. n=301
NCT04057456 COMPLETED
Cannabinoids and an Anti-inflammatory Diet for the Treatment of Neuropathic Pain After Spinal Cord Injury
Eldon Loh, MD n=14
NCT03901352 COMPLETED
Study of Mirogabalin for Central Neuropathic Pain
Daiichi Sankyo Co., Ltd. n=300
NCT04650074 COMPLETED
Effectiveness of Ketamine Administered by Mesotherapy in Complex Regional Pain Syndrome Type 1 (CRPS1)
Hospices Civils de Lyon n=31
NCT05324059 COMPLETED
Efficacy and Safety of Pregabalin/Tramadol Combination Versus Pregabalin in Acute Pain of Neuropathic Origin
Laboratorios Silanes S.A. de C.V. n=110
NCT03070132 WITHDRAWN
802NP301 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia
Biogen
NCT03637387 WITHDRAWN
802NP302 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia
Biogen
NCT05140863 COMPLETED
To Evaluate the Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Postherpetic Neuralgia
Haisco Pharmaceutical Group Co., Ltd. n=372
NCT05235191 COMPLETED
Effectiveness and Safety of Methadone Versus Placebo for the Control of Neuropathic Pain in Different Etiologies
University of Sao Paulo n=80
NCT04094662 COMPLETED
A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled 14-week Study of DS-5565 in Chinese Patients With Diabetic Peripheral Neuropathic Pain
Daiichi Sankyo Co., Ltd. n=393
NCT02607280 COMPLETED
DS-5565 Phase III Study for Renal Impairment in Japanese Subjects
Daiichi Sankyo Co., Ltd. n=35
NCT01701362 COMPLETED
Placebo-controlled Safety and Efficacy Study of Pregabalin in Subjects With Post-traumatic Peripheral Neuropathic Pain
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. n=542
NCT01202227 COMPLETED
An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic Pain
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. n=104
NCT01145417 TERMINATED
Pregabalin Trial In HIV Neuropathic Pain
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. n=217
NCT01270828 COMPLETED
Safety And Efficacy Study Of Once Daily Controlled Release Pregabalin In The Treatment Of Patients With Postherpetic Neuralgia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. n=806
NCT02318706 COMPLETED
DS-5565 Phase III Study for Diabetic Peripheral Neuropathic Pain
Daiichi Sankyo Co., Ltd. n=854
NCT03009500 COMPLETED
Randomized Controlled Trial of Efficacy and Safety of Local Anesthetics and Steroids for Chronic Peripheral Post-traumatic Neuropathic Pain
University Health Network, Toronto n=3
NCT02985216 COMPLETED
Clinical Trial of YHD1119 in Patients With Peripheral Neuropathic Pain
Yuhan Corporation n=371
NCT00986258 TERMINATED
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking WHO Step III Analgesics But Showing a Lack of Tolerability
Grünenthal GmbH n=136
NCT01755546 COMPLETED
Long-term Open-Label Safety Study to Evaluate EN3409
BioDelivery Sciences International n=304
NCT01325090 WITHDRAWN
Early Administration of Botox® in Neuropathic Pain Due to Thoracoscopy or Thoracotomy
University Hospital, Limoges
NCT01298765 COMPLETED
Longterm Safety Study of BEMA Buprenorphine in Subjects With Chronic Pain
BioDelivery Sciences International n=302
NCT02412917 TERMINATED
A Comparative Study of FV-100 vs. Valacyclovir for the Prevention of Post-Herpetic Neuralgia
ContraVir Pharmaceuticals, Inc. n=237
NCT01450163 COMPLETED
Evaluate The Efficacy and Safety Of Pregabalin In Prevention, Reduction of Oxaliplatin-Induced Painful Neuropathy
University of Sao Paulo n=200
NCT01364259 TERMINATED
A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia
Stanford University n=17
NCT02593721 COMPLETED
Hypoalgesic Effect of Neural Mobilization Versus Ibuprofen Pharmacologic Treatment
Universidad Europea de Madrid n=50
NCT01752322 COMPLETED
Efficacy and Tolerability of Lidocaine Plaster for Treatment of Long-term Local Nerve Pain
Grünenthal GmbH n=444
NCT00592904 COMPLETED
Evaluating E2007 (Perampanel) in Patients With Painful Diabetic Neuropathy (PDN) or Post-Herpetic Neuralgia (PHN)
Eisai Inc. n=262
NCT02099890 COMPLETED
The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury
Brock University n=20
NCT00861952 WITHDRAWN
Neuragen for Peripheral Diabetic Neuropathy
The Canadian College of Naturopathic Medicine
NCT01536314 COMPLETED
Prophylaxis of Neuropathic Pain by mémantine
University Hospital, Clermont-Ferrand n=43
NCT01124097 TERMINATED
Eslicarbazepine Acetate as Therapy in Post-Herpetic Neuralgia
Bial - Portela C S.A. n=240
NCT01920087 WITHDRAWN
Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain
Allodynic Therapeutics, Inc
NCT00872144 COMPLETED
Sativex for Treatment of Chemotherapy Induced Neuropathic Pain
Mary Lynch n=16
NCT01008553 COMPLETED
A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome
Janssen Pharmaceutical K.K. n=258
NCT00798083 COMPLETED
Neuropathic Pain Caused by Radiation Therapy
British Columbia Cancer Agency n=22
NCT07625410 COMPLETED
To Evaluate Efficacy of Monotherapy of Oxcarbazepine Versus Combination of Gabapentin With Oxcarbazepine in the Management of Trigeminal Neuralgia
Rehman Medical Institute - RMI n=44
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only