Data updated: Jun 28, 2026
Neuropathy Clinical Trial Landscape
Neuropathy is being studied across 279 clinical trials registered since 2008, with 74 programs currently active. The competitive pipeline includes 18 active Phase 3 trials, 36 active Phase 2 trials, and 12 active Phase 1 trials.
Top industry sponsors include argenx, WinSanTor, Inc, Rinri Therapeutics.
Trial activity
74 active / 279 total since 2008
Active by phase 18 Ph3 / 70 36 Ph2 / 150 12 Ph1 / 28 8 Ph4 / 31
Sponsor activity
Who is running trials now — green active, blue completed, red failed/terminated.
Sorted by active Active Done Failed
argenx 3 1 0
WinSanTor, Inc 1 1 0
Rinri Therapeutics 1 0 0
Life Biosciences Inc. 1 0 0
Dianthus Therapeutics 1 0 0
Dompé Farmaceutici S.p.A 1 0 0
VM Therapeutics LLC 1 0 0
Dogwood Therapeutics Inc. 1 0 0
Novo Nordisk 1 0 0
Qilu Pharmaceutical Co., Ltd. 1 0 0
Tarian Pharma 1 0 0
RDC Clinical Pty Ltd 1 0 0
Akeso 1 0 0
Bexion Pharmaceuticals, Inc. 1 0 0
AlgoTherapeutix 1 0 0
How the field has grown
New-trial starts peaked in 2026 (24 registered); 2025 saw 21. The right-hand chart shows median Phase 3 enrollment by start year — the number in parentheses is that year's Phase 3 trial count (37 in total), so single-trial years (and years with no Phase 3 starts) are obvious. Both are by trial start date; the current year is partial.
New trials started by year
2016 12
2017 11
2018 13
2019 16
2020 17
2021 11
2022 21
2023 18
2024 11
2025 21
2026 24
TheraRadar.com
Median Phase 3 enrollment by start year
2016 (2) 397
2017 (1) 142
2018 (4) 96
2019 (3) 43
2020 (2) 279
2021 (4) 84
2022 (4) 60
2023 (4) 68
2024 (2) 125
2025 (5) 50
2026 (6) 200
TheraRadar.com
Full trial pipeline
Every active and completed trial across Phase 1–4, with enrollment analytics. Sortable, filterable, exportable with Pro.
NCT07423390 RECRUITING
Study on the Efficacy and Safety of Mecobalamin in Preventing Taxane-related Peripheral Neuropathy
Qinghai Red Cross Hospital n=326
NCT07453888 RECRUITING
Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)
Dompé Farmaceutici S.p.A n=272
NCT05840562 RECRUITING
Capsaicin 179 mg Patch Versus Oral Duloxetine in Patients With Chemotherapy-induced Peripheral Neuropathy
Institut Cancerologie de l'Ouest n=274
NCT07481149 RECRUITING
Trial of a Virtual Exercise-based Rehabilitation Program to Treat Persistent Chemotherapy-Induced Peripheral Neuropathy (CIPN)
University Health Network, Toronto n=240
NCT07475065 NOT YET RECRUITING
The Effect of Oral DLBS1033 in Patients With Diabetic Polyneuropathy
Universitas Sebelas Maret n=34
NCT06742190 ACTIVE NOT RECRUITING
A Study to Assess the Efficacy and Safety of Empasiprubart Versus IVIg in Adults With Multifocal Motor Neuropathy
argenx n=154
NCT07410169 NOT YET RECRUITING
Efficacy and Safety of Hyperbaric Oxygen Therapy in Improving Nab-paclitaxel-Induced Peripheral Neuropathy
Guangdong Provincial People's Hospital n=160
NCT07406854 ACTIVE NOT RECRUITING
A Phase 3, Multicenter, Randomized, Double-Masked, Sham-Controlled Clinical Trial for Leber's Hereditary Optic Neuropathy (LHON) Associated With ND4 Mutation
Wuhan Neurophth Biotechnology Limited Company n=95
NCT07287592 NOT YET RECRUITING
Glutamine for the Prophylaxis of Vincristine-induced Neuropathy in Children and Adolescents With Cancer.
Ain Shams University n=70
NCT04715542 NOT YET RECRUITING
Stibium Metallicum Praeparatum 6x Versus Placebo in the Prevention of Paclitaxel-induced Peripheral Neurotoxicity
University of Bern n=120
NCT05136976 RECRUITING
Rituximab Therapy in Anti-Myelin Associated Glycoprotein Patients With Characteristics of Good Responders
Centre Hospitalier Universitaire de Saint Etienne n=90
NCT04299893 RECRUITING
Ozone Therapy in Chemotherapy-induced Peripheral Neuropathy: RCT (O3NPIQ)
Bernardino Clavo, MD, PhD n=42
NCT06994507 RECRUITING
GM1 Prophylaxis for Nab-paclitaxel-associated Chemotherapy-induced Peripheral Neuropathy (CIPN) in Patients With Breast Cancer
Qilu Pharmaceutical Co., Ltd. n=352
NCT05624138 RECRUITING
The Possible Protective Role of Ketotifen Against Oxaliplatin Induced Peripheral Neuropathy
Tanta University n=64
NCT05786599 RECRUITING
Methadone to Treat Painful Chemotherapy Induced Peripheral Neuropathy
University of British Columbia n=50
NCT06799351 RECRUITING
Gut Microbiome Profiles in Patients with Chemotherapy-induced Neuropathy in the RCT OzoParQT (NCT06706544).
Bernardino Clavo, MD, PhD n=42
NCT06706544 RECRUITING
Ozone Treatment in Paresthesia (Numbness, Tingling) Secondary to Chemotherapy-induced Peripheral Neuropathy
Bernardino Clavo, MD, PhD n=42
NCT04912843 RECRUITING
Gene Therapy Clinical Trial for the Treatment Of Leber's HereDitary Optic Neuropathy
Wuhan Neurophth Biotechnology Limited Company n=102
NCT03293524 COMPLETED
Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year
GenSight Biologics n=98
NCT06715462 WITHDRAWN
Efficacy and Safety of the N0750 Compared to Monotherapies in the Treatment of Painful Diabetic Peripheral Neuropathy
Eurofarma Laboratorios S.A.
NCT05084053 COMPLETED
A Study of TAK-771 in Japanese Participants With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) and Multifocal Motor Neuropathy (MMN)
Takeda n=26
NCT04873232 COMPLETED
A 6-Month Extension Study of VMDN-003-2 to Assess Engensis in Participants With Painful Diabetic Peripheral Neuropathy
Helixmith Co., Ltd. n=106
NCT05397665 COMPLETED
Pharmacodynamic EffIcacy and Clinical Benefit of AT 007 in Patients With Sorbitol Dehydrogenase (SORD) Deficiency
Applied Therapeutics, Inc. n=56
NCT05680870 COMPLETED
The Possible Protective Role of Omeprazole Against Oxaliplatin Induced Neuropathy in Cancer Patients
Aya Mohamed Sadek Elsaid n=46
NCT02936843 COMPLETED
Targeting Inflammation With Salsalate in Type 1 Diabetes Neuropathy
University of Michigan n=61
NCT03747562 WITHDRAWN
Study of Efficacy and Safety of Gabapentin to Reduce the Need for Strong Opioid Use in Head and Neck Cancer Patients.
University Hospital, Ghent
NCT03308448 COMPLETED
Traumatic Optic Neuropathy Treatment Trial 2
Iran University of Medical Sciences n=93
NCT01132326 COMPLETED
Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (Droxi-304)
Chelsea Therapeutics n=350
NCT05189535 COMPLETED
"Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients"
Ain Shams University n=66
NCT05619328 COMPLETED
A Prospective Clinical Trial to Evaluate the Efficacy and Safety of Neurotropic B-Vitamins in Clinically Diagnosed Peripheral Sensory Polyneuropathy of Different Etiologies.
Procter and Gamble n=323
NCT03555916 COMPLETED
Botulinum Toxin Injections for Oral Neuropathic Pain
Assistance Publique - Hôpitaux de Paris n=43
NCT02217267 COMPLETED
Long Term Outcome After Serial Lidocaine Infusion in Peripheral Neuropathic Pain
Mahidol University n=29
NCT01099449 COMPLETED
Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy
Alliance for Clinical Trials in Oncology n=362
NCT05567081 COMPLETED
Efficacy of Ultrasound-Guided PRP Versus Corticosteroid Injection in Patients With Ulnar Neuropathy at Elbow
Tanta University n=60
NCT05319275 COMPLETED
Study of Acetyllevocarnitine Hydrochloride Tablets in Chinese Patients With Paresthesias Caused by DPN
Haisco Pharmaceutical Group Co., Ltd. n=516
NCT04034355 TERMINATED
Preventive Treatment of OxaLiplatin Induced peripherAl neuRopathy in Adjuvant Colorectal Cancer
Egetis Therapeutics n=301
NCT03654729 TERMINATED
Preventive Treatment of Oxaliplatin Induced Peripheral Neuropathy in Metastatic Colorectal Cancer (POLAR-M)
Egetis Therapeutics n=291
NCT00666263 COMPLETED
Study of the Effectiveness of Intravenous Immune Globulin (10%) for the Treatment of Multifocal Motor Neuropathy
Baxalta now part of Shire n=50
NCT04877067 COMPLETED
Therapy of Toxic Optic Neuropathy Via Combination of Stem Cells With Electromagnetic Stimulation
Ankara Universitesi Teknokent n=18
NCT02638207 COMPLETED
Study to Evaluate Safety and Efficacy of Three Different Dosages of NewGam in Patients With Chronic Inflammatory Demyelinating Poly (Radiculo) Neuropathy
Octapharma n=142
NCT01049217 TERMINATED
Pregabalin Versus Placebo In The Treatment Of Neuropathic Pain Associated With HIV Neuropathy
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. n=377
NCT01455415 COMPLETED
Effect Of Pregabalin Treatment In Patients With Diabetic Nerve Pain Who Currently Use A Non-Steroid Anti-Inflammatory Drug (NSAID) For Another Pain
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. n=306
NCT01474772 COMPLETED
Efficacy and Safety Study of Pregabalin in the Treatment of Pain on Walking in Patients With Diabetic Peripheral Neuropathy (DPN)
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. n=217
NCT01288937 TERMINATED
A Placebo Controlled, Randomized, Double Blind Trial of Milnacipran for the Treatment of Idiopathic Neuropathy Pain
Columbia University n=6
NCT02341560 TERMINATED
Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)
Quark Pharmaceuticals n=732
NCT01086150 COMPLETED
Use of Topical Lidocaine to Reduce Pain in Patients With Diabetic Neuropathy
Albany Medical College n=51
NCT02281656 COMPLETED
Prospective Evaluation of Reverse End to Side Anterior Interosseous Nerve to Ulnar Nerve Transfer for Severe Compressive Ulnar Neuropathy at the Elbow
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's n=40
NCT02332005 COMPLETED
12-Month Efficacy and Safety of Diepalrestat in Adults With Diabetic Peripheral Neuropathy, a DB, Placebo-Controlled Study
NeuromaxBionevia n=330
NCT01911975 COMPLETED
Safety and Tolerability of Lacosamide in Patients With Gain-of-function Nav1.7 Mutations Related Small Fiber Neuropathy
Academisch Ziekenhuis Maastricht n=25
NCT02141035 COMPLETED
Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome
University of Alberta n=20
NCT00775645 COMPLETED
S0715: Acetyl-L-Carnitine in Preventing Neuropathy in Women With Stage I, II, or IIIA Breast Cancer Undergoing Chemo
SWOG Cancer Research Network n=437
NCT01775449 COMPLETED
Prevention of Oxaliplatin-induced Neuropathic Pain by a Specific Diet
University Hospital, Clermont-Ferrand n=80
NCT00489411 COMPLETED
Duloxetine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
Alliance for Clinical Trials in Oncology n=231
NCT02311907 COMPLETED
Glutathione in Preventing Peripheral Neuropathy Caused by Paclitaxel and Carboplatin in Patients With Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer
Alliance for Clinical Trials in Oncology n=195
NCT02434523 TERMINATED
Trial of the Treatment of Chronic Laryngitis With Amitryptiline
Boston Medical Center n=30
NCT02927951 COMPLETED
The Effect of Pregabalin on Pain Related to Walking in Patients With Diabetic Peripheral Neuropathy
Eastern Virginia Medical School n=44
NCT00998738 TERMINATED
Calcium and Magnesium in Preventing Peripheral Neuropathy Caused by Ixabepilone in Patients With Breast Cancer
Mayo Clinic n=1
NCT01827072 COMPLETED
Phase III Clinical Trial of NPB-01maintenance Therapy in Patients With Multifocal Motor Neuropathy.
Nihon Pharmaceutical Co., Ltd n=13
NCT01533428 COMPLETED
A Study to Evaluate Efficacy and Safety of a Single Application of Capsaicin 8%Transdermal Delivery System Compared to Placebo in Reducing Pain Intensity in Subjects With Painful Diabetic Peripheral Neuropathy (PDPN)
Astellas Pharma Inc n=369
NCT01478607 COMPLETED
A Study to Evaluate the Long-term Safety of Repeated QUTENZA Administration for Treatment of Pain Caused by Nerve Damage in Diabetic Patients
Astellas Pharma Inc n=468
NCT02099890 COMPLETED
The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury
Brock University n=20
NCT00861952 WITHDRAWN
Neuragen for Peripheral Diabetic Neuropathy
The Canadian College of Naturopathic Medicine
NCT01492920 WITHDRAWN
Acetyl-L-Carnitine Hydrochloride in Preventing Peripheral Neuropathy in Patients With Recurrent Ovarian Epithelial Cancer, Primary Peritoneal Cavity Cancer, or Fallopian Tube Cancer Undergoing Chemotherapy
Gynecologic Oncology Group
NCT00633880 COMPLETED
Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)
Chelsea Therapeutics n=181
NCT00738062 COMPLETED
Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)
Chelsea Therapeutics n=103
NCT00782340 COMPLETED
A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa
Chelsea Therapeutics n=263
NCT01041859 COMPLETED
A Study to Evaluate the Efficacy, Safety, and Tolerability of Tapentadol ER Compared With Placebo in Patients With Chronic, Painful Diabetic Peripheral Neuropathy
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. n=460
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only