Data updated: Jun 28, 2026
PCOS Clinical Trial Landscape
PCOS is being studied across 202 clinical trials registered since 2008, with 27 programs currently active. The competitive pipeline includes 9 active Phase 3 trials, 8 active Phase 2 trials, and 5 active Phase 1 trials.
Top industry sponsors include Wellizen Australia, Fujian Shengdi Pharmaceutical Co., Ltd..
Trial activity
27 active / 202 total since 2008
Active by phase 9 Ph3 / 59 8 Ph2 / 43 5 Ph1 / 20 5 Ph4 / 80
Sponsor activity
Who is running trials now — green active, blue completed, red failed/terminated.
Sorted by active Active Done Failed
Wellizen Australia 1 0 0
Fujian Shengdi Pharmaceutical Co., Ltd. 1 0 0
How the field has grown
New-trial starts peaked in 2016 (19 registered); 2025 saw 15. The right-hand chart shows median Phase 3 enrollment by start year — the number in parentheses is that year's Phase 3 trial count (36 in total), so single-trial years (and years with no Phase 3 starts) are obvious. Both are by trial start date; the current year is partial.
New trials started by year
2016 19
2017 14
2018 9
2019 13
2020 12
2021 5
2022 8
2023 13
2024 10
2025 15
2026 4
TheraRadar.com
Median Phase 3 enrollment by start year
2016 (6) 90
2017 (2) 93
2018 (4) 164
2019 (3) 161
2020 (2) 174
2021 (1) 128
2022 (1) 12
2023 (7) 70
2024 (3) 74
2025 (6) 81
2026 (1) 204
TheraRadar.com
Full trial pipeline
Every active and completed trial across Phase 1–4, with enrollment analytics. Sortable, filterable, exportable with Pro.
NCT03059173 RECRUITING
Interest of Myo-inositol Supplementation in Women With Polycystic Ovarian Syndrome
University Hospital, Lille n=276
NCT05326087 NOT YET RECRUITING
Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Women With PCOS Undergoing PGT-A
ShangHai Ji Ai Genetics & IVF Institute n=204
NCT05819853 RECRUITING
Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome
University of Colorado, Denver n=80
NCT07120815 NOT YET RECRUITING
Optimizing Metformin Use in Polycystic Ovary Syndrome
Helsinki University Central Hospital n=184
NCT06836128 RECRUITING
The Combined Effect of N-Acetyl Cysteine and Metformin in Polycystic Ovary Syndrome Patients
Cairo University n=102
NCT06896981 RECRUITING
Semaglutide in Women With Polycystic Ovary Syndrome and Obesity
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh n=30
NCT06576375 RECRUITING
Efficacy of Dapagliflozin Versus Metformin in Polycystic Ovary Syndrome
Future University in Egypt n=70
NCT05646199 NOT YET RECRUITING
Semaglutide vs Metformin in Polycystic Ovary Syndrome (PCOS)
University of Hull n=60
NCT06405243 NOT YET RECRUITING
Myoinositol, L-arginine and Chromium With Letrozole for Ovulation Induction in Polycystic Ovarian Syndrome Patients
Beni-Suef University n=100
NCT03625531 COMPLETED
A Trial of Personalized Acupuncture, Fixed Acupuncture, Letrozole and Placebo on Live Birth in Women With PCOS
Hongxia Ma n=1,103
NCT07323589 COMPLETED
Impact of Myo-Inositol Alone vs Myo-Inositol Plus Metformin on Conception, Adherence, and Tolerability in PCOS
PAEC general hospital n=120
NCT07143682 COMPLETED
Letrozole Step up Protocol for Ovulation Induction in Infertile Women With Polycystic Ovary Syndrome
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh n=70
NCT07278128 COMPLETED
Evaluation of the Therapeutic Effects of Curcumin on Changes in Lipid, Metabolic, and Hormonal Profiles, Liver Enzyme Activity, and Ultrasonography Morphology of the Liver in Women With Polycystic Ovary Syndrome and Nonalcoholic Fatty Liver Disease: A Double-blind, Placebo-controlled Clinical Trial
Fateme Moshirenia n=74
NCT03919929 COMPLETED
Treating PCOS With Semaglutide vs Active Lifestyle Intervention
University of Colorado, Denver n=60
NCT03229057 COMPLETED
Comparing the Effects of Oral Contraceptive Pills Versus Metformin
Anuja Dokras n=240
NCT06725004 COMPLETED
Oxytocin Versus Human Chorionic Gonadotropin as Trigger in Ovulation Induction
Shakeela Ishrat n=60
NCT06140108 COMPLETED
Empagliflozin vs Metformin on Metabolic Dysfunction in Polycystic Ovary Syndrome With or Without Comorbidity or Multimorbidity
SINA Health Education and Welfare Trust n=70
NCT00427700 COMPLETED
Induction of Ovulation With Raloxifene or Clomiphene Citrate in Polycystic Ovarian Syndrome
Hospital de Clinicas de Porto Alegre n=82
NCT06486870 COMPLETED
Comparison Between Two Ovulation Induction Therapies and LOD on Clinical Outcomes in CC-Resistant PCOS Women
Cairo University n=183
NCT02157974 COMPLETED
Liver and Fat Regulation in Overweight Adolescent Girls
University of Colorado, Denver n=92
NCT06403488 COMPLETED
Letrozole Dose Increments in PCOS Patients Resistant to Letrozole
Beni-Suef University n=102
NCT06227676 COMPLETED
Effect of 'Cramp Bites' on Period Cramps in Women Aged 18-25
Cornell University n=12
NCT03197077 COMPLETED
Optimisation of Follicular Recruitment in IVM Cycles
Universitair Ziekenhuis Brussel n=145
NCT05702957 COMPLETED
Letrozole vs Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovarian Syndrome
Services Institute of Medical Sciences, Pakistan n=220
NCT04213677 COMPLETED
Dapagliflozin Efficacy and Action in PCOS
Nanfang Hospital, Southern Medical University n=165
NCT02491333 COMPLETED
The RCT of Acupuncture on PCOS Combined With IR
The First Affiliated Hospital of Guangzhou Medical University n=342
NCT01482286 TERMINATED
Effect of Weight and Insulin Sensitivity on Reproductive Function in PCOS
Pennington Biomedical Research Center n=32
NCT05189873 COMPLETED
GnRH Agonist Plus Hormone Replacement Therapy vs Hormone Replacement Therapy on IVF Outcomes
Tehran University of Medical Sciences n=128
NCT02491320 COMPLETED
The Clinical Trial of Acupuncture Pre-treatment on PCOS
The First Affiliated Hospital of Guangzhou Medical University n=384
NCT03480022 COMPLETED
Liraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS
Woman's n=88
NCT04870502 COMPLETED
Effect of Ubiquinol Supplementation on Ovulation Induction in Clomiphene Citrate Resistance
Saudi German Hospital - Madinah n=161
NCT04852510 COMPLETED
Amelioration of Polycystic Ovary Syndrome Related Disorders by Supplementation of Thymoquinone and Metformin
Saudi German Hospital - Madinah n=253
NCT03981861 COMPLETED
Metabolic and Neuro-Endocrine Effect of Treating PCOS in Adolescents
Children's Mercy Hospital Kansas City n=12
NCT02635386 COMPLETED
EQW, DAPA, EQW/DAPA, DAPA/MET ER and PHEN/TPM ER in Obese Women With PolycysticOvary Syndrome (PCOS)
Woman's n=119
NCT03778099 COMPLETED
The Effect of Cinnamon on Ovulation Induction in Women With Polycystic Ovary Syndrome
King Abdulaziz University n=33
NCT03008551 COMPLETED
Empagliflozin vs Metformin in PCOS
Hull University Teaching Hospitals NHS Trust n=40
NCT03792984 COMPLETED
The Effect of Calcium and Vitamin D Supplements on Metabolic and Hormonal Disturbances in Polycystic Ovary Syndrome Patients
Damascus University n=40
NCT01999686 COMPLETED
PCOS Treatment Using DLBS3233, Metformin, and Combination of Both
Dexa Medica Group n=186
NCT01154192 COMPLETED
Theca Cell Function in Adolescents With Polycystic Ovary Syndrome (PCOS)
University of California, San Diego n=24
NCT03201601 COMPLETED
Evaluation of the Mixture Myoinositol:D-chiro-inositol 3.6:1 in Women With Polycystic Ovary Syndrome
Biosearch S.A. n=60
NCT01733459 COMPLETED
Efficacy and Safety of DLBS3233 in Subjects With Polycystic Ovary Syndrome (PCOS)
Dexa Medica Group n=124
NCT03440359 COMPLETED
Vaginal Progesterone Supplementation in Women With PCOS Undergoing Ovulation Induction With Letrozole
Eastern Virginia Medical School n=52
NCT01402336 COMPLETED
GnRH Antagonist Versus GnRH Agonist in Polycystic Ovary Syndrome During in Vitro Fertilization - Embryo Transfer
Seoul National University Hospital n=43
NCT01483118 COMPLETED
Cinnamon Extract on Menstrual Cycles in PolyCystic Ovary Syndrome (PCOS)
Rogerio A. Lobo n=45
NCT02022007 COMPLETED
Saxagliptin + Metformin Compared to Saxagliptin or Metformin Monotherapy in PCOS Women With Impaired Glucose Homeostasis
Woman's n=38
NCT03086005 COMPLETED
Study to Assess the Effect of Metformin Supplementation on IVF Outcome in Patients With Polycystic Ovarian Syndrome.
Chung-Hoon Kim n=24
NCT02328404 COMPLETED
The Effect of Vitamin D Supplementation Among Overweight Jordanian Women With Polycystic Ovary Syndrome (PCOS)
Hayat Pharmaceutical Co. PLC n=60
NCT01709942 COMPLETED
Use of Degarelix in Controlled Ovarian Hyperstimulation (COH) Protocol for Women With PoliCystic Ovarian Syndrome (PCOS)
Centre for Endocrinology and Reproductive Medicine, Italy n=80
NCT01788215 COMPLETED
Effect of a Commonly Used Antibiotic, Doxycycline, in Women With Polycystic Ovarian Syndrome
University of Rochester n=10
NCT01653743 COMPLETED
Trial to Assess the Clinical Efficacy and Safety of MSJ-0011 in Inducing Ovulation in Anovulatory or Oligo-ovulatory Japanese Women
Merck KGaA, Darmstadt, Germany n=81
NCT01638988 WITHDRAWN
Clomifene Citrate Versus Metformin in First-line Treatment of Infertility in Patients With Polycystic Ovary Syndrome and a Resistance to Insulin
Clinique Ovo
NCT01185704 COMPLETED
Analysis of Two Therapeutic With Cetrotide® in Polycystic Ovarian (PCO) Women in Assisted Reproductive Technology (ART)
Merck KGaA, Darmstadt, Germany n=136
NCT01577017 COMPLETED
The Effects of Letrozole And Clomiphene Citrate For Induction of Ovulation In Polycystic Ovarian Syndrome(PCOS)
Nik Hazlina n=150
NCT01581814 COMPLETED
Effects of Drospirenone-ethinylestradiol and/or Metformin on Cardiovascular Risk in Hyperinsulinemic Women With Polycystic Ovary Syndrome
Catholic University of the Sacred Heart n=99
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only