Data updated: Jun 28, 2026
Peptic Ulcer Clinical Trial Landscape
Peptic Ulcer is being studied across 361 clinical trials registered since 2008, with 82 programs currently active. The competitive pipeline includes 14 active Phase 3 trials, 26 active Phase 2 trials, and 10 active Phase 1 trials.
Trial activity
82 active / 361 total since 2008
Active by phase 14 Ph3 / 96 26 Ph2 / 115 10 Ph1 / 52 32 Ph4 / 98
Sponsor activity
Who is running trials now — green active, blue completed, red failed/terminated.
Sorted by active Active Done Failed
Cellution Biologics 2 1 0
TR Therapeutics 2 0 0
Applied Biologics, LLC 2 0 0
BioLab Holdings 2 0 0
Sequence LifeScience, Inc. 2 0 0
Tiger Biosciences, LLC. 2 0 0
RHEACELL GmbH & Co. KG 1 3 1
MediWound Ltd 1 2 0
Oneness Biotech Co., Ltd. 1 1 1
Onconic Therapeutics Inc. 1 2 0
Blue Blood Biotech Corp. 1 1 0
Addpharma Inc. 1 1 0
Rion Inc. 1 1 0
Energenesis Biomedical Co., Ltd. 1 1 0
Il-Yang Pharm. Co., Ltd. 1 1 0
How the field has grown
New-trial starts peaked in 2025 (36 registered). The right-hand chart shows median Phase 3 enrollment by start year — the number in parentheses is that year's Phase 3 trial count (38 in total), so single-trial years (and years with no Phase 3 starts) are obvious. Both are by trial start date; the current year is partial.
New trials started by year
2016 19
2017 15
2018 14
2019 15
2020 12
2021 19
2022 20
2023 18
2024 16
2025 36
2026 15
TheraRadar.com
Median Phase 3 enrollment by start year
2016 (4) 43
2017 (3) 234
2018 (4) 100
2019 (1) 13
2020 (3) 106
2021 (3) 423
2022 (3) 284
2023 (4) 215
2024 (4) 307
2025 (8) 147
2026 (1) 300
TheraRadar.com
Full trial pipeline
Every active and completed trial across Phase 1–4, with enrollment analytics. Sortable, filterable, exportable with Pro.
NCT07488247 RECRUITING
Phase IIb and III Safety and Efficacy Study Chlorin E6 Gel Photodynamic Therapy for Diabetic Foot Ulcers:
United Medical and Dental College n=300
NCT06568627 RECRUITING
A Double Blind Study Performed to Evaluate the Efficacy and the Safety of EscharEx in Debridement of VLU (VALUE)
MediWound Ltd n=216
NCT07391319 RECRUITING
The Prospective, Double-blind, Multicenter, Placebo-controlled, Randomized, Comparative Clinical Trial
JSC NextGen n=144
NCT06658002 RECRUITING
Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A
University of California, San Francisco n=150
NCT05930210 RECRUITING
A Study to Evaluate ENERGI-F703 GEL in Diabetic Foot Ulcer
Energenesis Biomedical Co., Ltd. n=230
NCT06489028 ACTIVE NOT RECRUITING
Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Therapy-resistant CVU (Phase III)
RHEACELL GmbH & Co. KG n=250
NCT06910579 RECRUITING
Oxygenated Gel Therapy in the Management of Oral Aphthous Ulcers
British University In Egypt n=30
NCT06531512 ACTIVE NOT RECRUITING
Evaluate the Efficacy and Safety of Xianglei Tangzu Gao for the Treatment of Wagner Grade II Diabetic Foot Ulcers
Oneness Biotech Co., Ltd. n=120
NCT06297967 RECRUITING
Acetic Acid 2% Solution for Skin Ulcers
Consorci Sanitari de l'Alt Penedès i Garraf n=104
NCT06284876 RECRUITING
Study to Evaluate the Efficacy and Safety of Ilaprazole 10 mg in Prevention NSAIDs Associated Peptic Ulcer
Il-Yang Pharm. Co., Ltd. n=416
NCT06786403 NOT YET RECRUITING
The Effects of Bromelain Supplement in Patients with Diabetic Foot Ulcers
Dr Azita Hekmatdoost n=70
NCT06439563 RECRUITING
Study to Evaluate the Efficacy and Safety of JP-1366 in the Prevention of NSAIDs-Induced Peptic Ulcers
Onconic Therapeutics Inc. n=364
NCT03553563 COMPLETED
A Study of Esomeplazole (D961H) in Japanese Paediatric Patients With Reflux Esophagitis, Gastric Ulcer or Duodenal Ulcer
AstraZeneca n=50
NCT02563522 TERMINATED
Safety and Efficacy Study of Engensis (VM202) in the Treatment of Chronic Non-Healing Foot Ulcers
Helixmith Co., Ltd. n=44
NCT02731638 COMPLETED
Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers
University of California, San Francisco n=70
NCT04569409 COMPLETED
Clinical Study to Evaluate Efficacy and Safety of ALLO-ASC-DFU in Patients With Diabetic Wagner Grade 2 Foot Ulcers.
Anterogen Co., Ltd. n=104
NCT02570321 COMPLETED
Cross-linking for Corneal Ulcers Treatment Trial
University of California, San Francisco n=147
NCT04450693 COMPLETED
Cryopreserved Human Umbilical Cord (TTAX01) for Late Stage, Complex Non-healing Diabetic Foot Ulcers (AMBULATE DFU II)
BioTissue Holdings, Inc n=106
NCT05656092 COMPLETED
A Study to Evaluate the Effiacy and Safety of HIP0612 in Patients With Gastric Ulcer
Hanmi Pharmaceutical Company Limited n=199
NCT05764876 COMPLETED
Repurposing Clinically Approved Drugs for Yaws With an Insight Into the Cutaneous Ulcer Disease Syndrome (Trep-AByaws)
Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia n=384
NCT05607979 COMPLETED
Restoring Tissue and Evaluating Novel Treatments for Efficacy in Wounds
Lavior Pharma Inc. n=75
NCT05227833 COMPLETED
Vonoprazan Efficacy to Prevent Post Variceal Band Ligation Ulcer
Alexandria University n=284
NCT05448001 COMPLETED
Clinical Trial to Evaluate the Efficacy and Safety of JP-1366 in Patients With Gastric Ulcer
Onconic Therapeutics Inc. n=329
NCT04784910 COMPLETED
Study to Evaluate the Efficacy and Safety of DWP14012 in Prevention of NSAIDs Induced Peptic Ulcer
Daewoong Pharmaceutical Co. LTD. n=423
NCT04176120 COMPLETED
Cryopreserved Human Umbilical Cord (TTAX01) for Late Stage, Complex Non-healing Diabetic Foot Ulcers (AMBULATE DFU)
BioTissue Holdings, Inc n=220
NCT03998436 COMPLETED
Phase 3 Study to Evaluate the Safety and Efficacy of Galnobax® in Treating Diabetic Foot Ulcers
Novalead Pharma Private Limited n=176
NCT03370874 COMPLETED
Clinical Study to Evaluate Efficacy and Safety of ALLO-ASC-DFU in Patients With Diabetic Foot Ulcers.
Anterogen Co., Ltd. n=150
NCT03476876 COMPLETED
Comparative Effectiveness of Two Acellular Matrices (Dermacell vs. Integra) for Management of Deep Diabetic Foot Ulcers
Baylor College of Medicine n=34
NCT05841394 COMPLETED
A Multi-center, Double-blinding, Parallel and Positive-controlled Phase III Clinical Trial for Efficacy and Safety Evaluation of Ilaprazole Sodium for Injection on Prevention of Stress Ulcer Bleeding
Livzon Pharmaceutical Group Inc. n=449
NCT05010954 COMPLETED
Efficacy and Safety of LXI-15028 Comparing With Lansoprazole in the Treatment of Duodenal Ulcer
Shandong Luoxin Pharmaceutical Group Stock Co., Ltd. n=400
NCT02769494 WITHDRAWN
The Efficacy of Topical Mesalazine Sustained-Release Tablets in Crohn's Disease Patients With Oral Ulcer
Xijing Hospital of Digestive Diseases
NCT02447172 COMPLETED
Study of a Topical Gentamicin-Collagen Sponge Along With Systemic Antibiotic in Infected Diabetic Foot Ulcers
Innocoll n=524
NCT02427802 COMPLETED
Study of a Topical Gentamicin-Collagen Sponge Along With Systemic Antibiotic in Infected Diabetic Foot Ulcers
Innocoll n=612
NCT03050307 COMPLETED
Comparison of TAK-438 (Vonoprazan) to Lansoprazole in the Treatment of Gastric Ulcer Participants With or Without Helicobacter Pylori Infection
Takeda n=234
NCT04140591 TERMINATED
Proton Pump Inhibitor Plus Propranolol Versus Proton Pump Inhibitor Alone on Peptic Ulcer Healing in Patients With Liver Cirrhosis
Taipei Veterans General Hospital, Taiwan n=10
NCT03050359 COMPLETED
Comparison of TAK-438 (Vonoprazan) to Lansoprazole in the Treatment of Duodenal Ulcer Participants With or Without Helicobacter Pylori Infection
Takeda n=533
NCT04310280 COMPLETED
Effects of Local Insulin on Varicose Ulcers for Wound Healing
Hospital Central "Dr. Ignacio Morones Prieto" n=13
NCT01794312 COMPLETED
Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer
Laboratoires Thea n=152
NCT01450943 COMPLETED
VA MERIT: A Comparative Efficacy Study: Treatment of Non-Healing Diabetic
VA Office of Research and Development n=120
NCT02761512 COMPLETED
Study to Evaluate the Safety and Efficacy of CJ-12420 in Patients With Gastric Ulcer
HK inno.N Corporation n=306
NCT02166008 COMPLETED
Cytoprotective Agent and Peptic Ulcer in Dual Antiplatelet :RCT
King Chulalongkorn Memorial Hospital n=142
NCT00997035 COMPLETED
The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo
University of California, San Francisco n=240
NCT01998776 COMPLETED
Evaluate Misoprostol for the Healing of Small Bowel Ulcers in Low-dose Aspirin Users Complicated by Small Bowel Bleeding
Chinese University of Hong Kong n=82
NCT02158806 COMPLETED
Low Dose Aspirin for Venous Leg Ulcers
University of Auckland, New Zealand n=251
NCT00662831 COMPLETED
Study Of The Effect Of Fragmin In The Treatment Of Neuroischaemic Foot Ulcers In Diabetic Patients
Pfizer n=276
NCT01833585 COMPLETED
Treatment of Chronic Critical Limb Ischemia With G-CSF-mobilized Autologous Peripheral Blood Mononuclear Cells
Mahidol University n=8
NCT01814267 COMPLETED
Medico-economical Assessment of Telemedicine During Chronic Diabetes-related Foot Wound Management
University Hospital, Grenoble n=14
NCT02565745 TERMINATED
Skin Dressings Versus Lubrication to Prevent Pressure Ulcers: A Randomized Trial
Fundación Cardioinfantil Instituto de Cardiología n=689
NCT01840085 TERMINATED
Open-Label Study in Diabetic Foot Ulcers (DFU), to Evaluate Safety of 0.03% DSC127 Topical Gel in Chronic Use
Integra LifeSciences Corporation n=261
NCT03362281 COMPLETED
Ilaprazole for the Treatment and Prevention of Peptic Ulcer Bleeding in Chinese Patients
Livzon Pharmaceutical Group Inc. n=540
NCT02802995 TERMINATED
Safety And Efficacy Of Topical Platelet Rich Plasma And Thrombin Coagulum
University of Witwatersrand, South Africa n=15
NCT02236793 COMPLETED
A Phase 3 Clinical Trial to Assess the Effectiveness of BioChaperone PDGF-BB In the Treatment of Chronic Diabetic Foot Ulcer
Adocia n=252
NCT01982318 WITHDRAWN
A Prospective Randomized, Double-Blind, Placebo-Controlled Trial Comparing VitroGro® ECM to Placebo in Patients With Venous Leg Ulcers
Tissue Therapies Ltd.
NCT02157376 COMPLETED
Stress Ulcer Prophylaxis of Intravenous Esomeprazole in Chinese Seriously Ill Patients
AstraZeneca n=343
NCT02153398 COMPLETED
A Phase I/III Study of D961H 10 mg and 20 mg in Japanese Paediatric Patients With Gastrointestinal Acid Related Diseases
AstraZeneca n=55
NCT02625792 COMPLETED
Role of Hemostatic Powder (Endo-clotTM) in Prevention of Bleeding Within High Risk Patients After ESD
Yonsei University n=45
NCT01853384 TERMINATED
Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers
Healthpoint n=252
NCT02847455 COMPLETED
Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients
Livzon Pharmaceutical Group Inc. n=408
NCT01757275 COMPLETED
High Dose Esomeprazole Na for Prevention of Rebleeding After Successful Endoscopic Therapy of a Bleeding Peptic Ulcer
AstraZeneca n=239
NCT00961350 COMPLETED
A Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers
POZEN n=530
NCT00960869 COMPLETED
Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers
POZEN n=519
NCT02290327 COMPLETED
Re-Evaluating the Inhibition of Stress Erosions: Gastrointestinal Bleeding Prophylaxis In ICU
McMaster University n=91
NCT01142245 COMPLETED
Effect of IV and Oral Esomeprazole in Prevention of Recurrent Bleeding From Peptic Ulcers After Endoscopic Therapy
Chinese University of Hong Kong n=263
NCT02219529 COMPLETED
Magnetic-controlled Capsule Endoscopy vs. Gastroscopy for Detection of Gastric Diseases
Changhai Hospital n=350
NCT02004626 WITHDRAWN
Evaluate the Noninferiority of Medicines Treating Uninfected Pressure Ulcers.
Cristália Produtos Químicos Farmacêuticos Ltda.
NCT02379468 COMPLETED
Efficacy & Safety of Pedyphar Ointment in Diabetic Foot Ulcer Treatment
European Egyptian Pharmaceutical Industries n=80
NCT01531517 TERMINATED
Study of the Efficacy of PedyPhar® Ointment on the Diabetic Foot Ulcers
European Egyptian Pharmaceutical Industries n=47
NCT01217476 COMPLETED
The TRAfermin in Neuropathic Diabetic Foot Ulcer Study - Northern Europe The TRANS-North Study
Olympus Biotech Corporation n=207
NCT01217463 COMPLETED
The TRAfermin in Neuropathic Diabetic Foot Ulcer Study - Southern Europe The TRANS-South Study
Olympus Biotech Corporation n=201
NCT02084420 COMPLETED
Efficacy/Safety Study as H. Pylori Eradication of Triple Therapy for 7 Days Treatment
Il-Yang Pharm. Co., Ltd. n=323
NCT01568385 COMPLETED
A Unblinded Study of TAK-438 (20 mg) for Prevention of Recurrence of Gastric or Duodenal Ulcer During Long-Term Non-Steroid Anti-Inflammatory Drug (NSAID) Therapy
Takeda n=30
NCT01568398 COMPLETED
A Unblinded Study of TAK-438 (20 mg) for Prevention of Recurrence of Gastric or Duodenal Ulcer During Long-Term Low-Dose Aspirin Therapy
Takeda n=27
NCT01541930 COMPLETED
An Open, Uncontrolled Study of GK567 in the Deodorization of Malodorous Fungating Neoplastic Tumours
Galderma R&D n=21
NCT01333670 COMPLETED
Efficacy of Prontosan Solution on Chronic Ulcers
Associazione Infermieristica per lo studio delle Lesioni Cutanee n=289
NCT01586481 COMPLETED
Off- Loading Shoe to Improve Healing and Prevention of Recurrence of Neuropathic Diabetic Plantar Foot Ulcers
Assistance Publique - Hôpitaux de Paris n=33
NCT01891760 COMPLETED
Long-Term Follow-Up to the DEVO Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers
Shire Regenerative Medicine, Inc. n=225
NCT01452724 COMPLETED
Efficacy and Safety of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Duodenal Ulcer
Takeda n=372
NCT01591434 COMPLETED
Study to Evaluate the Performance of AQUACEL® Extra™ in Venous Leg Ulcers
ConvaTec Inc. n=65
NCT01452711 COMPLETED
Efficacy of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Gastric Ulcer
Takeda n=482
NCT01828645 COMPLETED
Residual Gastric Volume After the Ingestion of a Beverage Containing Carbohydrates Plus Whey Protein
Federal University of Mato Grosso n=30
NCT01150162 COMPLETED
Mucosta in Gastric Ulcer Treatment, Effectiveness and Safety Evaluation
Otsuka Pakistan Limited n=129
NCT00838500 COMPLETED
THERMES ET VEINES: Spa for Prevention of Leg Ulcers
Association Francaise pour la Recherche Thermale n=425
NCT00796042 COMPLETED
Interdisciplinary Pressure Management & Mobility Program as an Alternative to Usual Care: A Pilot Study
University of Western Ontario, Canada n=14
NCT01082445 COMPLETED
Effects of N-acetylcysteine on Diabetic Foot Oxygenation
University of Turin, Italy n=100
NCT01524081 COMPLETED
Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures
The Faculty Hospital Na Bulovce n=187
NCT00765063 COMPLETED
The Effect Of Fragmin In The Treatment Of Neuroischaemic Foot Ulcers In Diabetic Patients (A6301086)
Pfizer n=62
NCT01389362 COMPLETED
The Healing Effect of a Two-Herb Recipe on Foot Ulcer in Chinese Patients With Type 2 Diabetes
Chinese University of Hong Kong n=16
NCT00979836 SUSPENDED
Calcium Dobesilate for Chronic Venous Wounds
Fundacion Iberoamericana Itaca n=230
NCT00804414 COMPLETED
Efficacy and Safety Study of Soluble Beta-1,3/1,6-glucan (SBG) Versus Placebo in Chronic Diabetic Foot Ulcers
Biotec Pharmacon ASA n=133
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only