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Data updated: Jun 28, 2026

BONTRIL PDM (phendimetrazine tartrate) · BAUSCH

Metabolic Approved 1976-12-22

Phendimetrazine tartrate is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction in patients with an initial body mass index (BMI) of 30 kg/m 2 or higher who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone. Below is a chart of Body Mass Index (BMI) based on various heights and weights.

Source: FDA Label
1
Indication
--
Phase 3 Trials
49
Years on Market

Details

Status
Prescription
First Approved
1976-12-22
Routes
ORAL
Dosage Forms
TABLET

Companies

Active Ingredient: PHENDIMETRAZINE TARTRATE

BONTRIL PDM Approval History

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Original
New Indication
New Form
Label Update
21 FDA actions from 1976 to 2008
Jan 2008 SUPPL
Label · Labeling
Dec 2001 SUPPL
Mfg · Manufacturing (CMC)
Aug 2001 SUPPL
Mfg · Manufacturing (CMC)

What BONTRIL PDM Treats

1 indications

BONTRIL PDM is approved for 1 conditions since its original approval in 1976. These indications span multiple therapeutic areas including oncology, immunology, and more.

Source: FDA Label

BONTRIL PDM Competitive Set

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Key Completed Trials

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Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

BONTRIL PDM FDA Label Details

Indications & Usage

Phendimetrazine tartrate is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction in patients with an initial body mass index (BMI) of 30 kg/m 2 or higher who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone. Below is a chart of Body Mass Index (BMI) based on various heights and weights. BMI is calculated by taking the patient’s weight in kilograms (kg), divided by the patient’s height, in meters (m), squared. Metric conversions are as follow: pounds ÷ 2.2 = kg; ...

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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.