TheraRadar
Data updated: Jun 28, 2026

CITANEST PLAIN (prilocaine hydrochloride) · AstraZeneca

Other Approved 1965-11-18

CITANEST PLAIN is FDA-approved to treat 2 conditions (same as PRILOCAINE HYDROCHLORIDE).

Source: FDA Label
1
Indication
--
Phase 3 Trials
1
Priority Reviews
60
Years on Market

Details

Status
Discontinued
First Approved
1965-11-18
Routes
INJECTION
Dosage Forms
INJECTABLE

Companies

Active Ingredient: PRILOCAINE HYDROCHLORIDE

CITANEST PLAIN Approval History

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Original
New Indication
New Form
Label Update
20 FDA actions from 1965 to 2000
Dec 2000 SUPPL Priority
Mfg · Manufacturing (CMC)
May 1997 SUPPL Priority
Label · Labeling
May 1996 SUPPL Priority
Mfg · Manufacturing (CMC)

What CITANEST PLAIN Treats

2 indications

CITANEST PLAIN is approved for 2 conditions since its original approval in 1965. These indications span multiple therapeutic areas including oncology, immunology, and more.

  • Local anesthesia for dental procedures
  • Nerve block and infiltration in dentistry

Same approved indications as PRILOCAINE HYDROCHLORIDE (same active ingredient).

Source: FDA Label
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Active Pipeline

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Ongoing clinical trials by development phase

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Key Completed Trials

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Completed studies with published results, ranked by significance

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Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

CITANEST PLAIN FDA Label Details

Indications & Usage

CITANEST PLAIN is FDA-approved to treat 2 conditions — same approved indications as PRILOCAINE HYDROCHLORIDE.

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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.