TheraRadar
Data updated: Jun 28, 2026

HYDROCODONE BITARTRATE

Trial Activity: Stable 1 active trials
Pain Approved 1997-09-23

Development Insights

M.D. Anderson Cancer Center conducting 1 trials (33%)
3 indications explored (Focused)
intra-abdominal cancer (1 trials)
pain (1 trials)
chronic pain (1 trials)
2
Indications
--
Phase 3 Trials
28
Years on Market

Details

Status
Prescription
First Approved
1997-09-23
Routes
ORAL
Dosage Forms
TABLET, EXTENDED RELEASE, CAPSULE, EXTENDED RELEASE

Companies

Active Ingredient: HYDROCODONE BITARTRATE

HYDROCODONE BITARTRATE Approval History

2021
2022
2023
2024
2025
2026
Original
New Indication
New Form
Label Update
63 FDA actions from 2020 to 2026
Jun 2026 SUPPL
Update · REMS
Dec 2025 SUPPL
Label · Labeling
Sep 2025 SUPPL
Label · Labeling

What HYDROCODONE BITARTRATE Treats

2 FDA approvals

Originally approved for its first indication in 2020 . Covers 2 distinct patient populations.

  • Other (2)
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Clinical Trial Registry

3 trials
Trial Sponsor ID Phase Status Title
NCT06585163 QEV-817-101 5R44DA055336 Ph 1 not yet recruiting Study to Investigate the Safety, Tolerability and Pharmacokinetics of QEV-817 Oral Suspension
NCT01081912 results posted ZX002-0801 Ph 3 completed Phase 3 Study of Hydrocodone Bitartrate Controlled-release Capsules in Subjects With Chronic Low Back Pain
NCT01115569 results posted ZX002-0802 Ph 3 completed Long-Term Study of Hydrocodone Bitartrate Controlled-release Capsules in Subjects With Chronic Pain
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Active Pipeline

Pro

Ongoing clinical trials by development phase

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Key Completed Trials

Pro

Completed studies with published results, ranked by significance

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📊

Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

HYDROCODONE BITARTRATE FDA Label Details

Looking for the branded version?

HYDROCODONE BITARTRATE AND IBUPROFEN

Full clinical data, patents, trials, and competitive landscape for hydrocodone bitartrate.

See HYDROCODONE BITARTRATE AND IBUPROFEN

Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.

How We Calculate These Metrics

Trial Activity Stage

Measures the current development activity pattern based on trial phases, status, and trends. Important: This measures R&D activity, not commercial lifecycle.

Trial statuses: "Active" means recruiting or ongoing. "Completed" means reached planned endpoint. "Terminated" means stopped early—often due to safety, efficacy, or business reasons.

  • Growth: High proportion of early-phase trials (Phase 1/2), active development
  • Expansion: Significant Phase 3 activity, approaching or pursuing approvals
  • Mature: Substantial Phase 4 post-marketing studies
  • Stable: Mixed phase distribution, steady development
  • Declining: Low active trial ratio, reduced R&D investment