PIPERACILLIN AND TAZOBACTAM (piperacillin sodium) · SHANDONG
Piperacillin and tazobactam is an intravenous combination of a penicillin-class antibacterial and a beta-lactamase inhibitor. It is indicated for the treatment of moderate-to-severe infections, including intra-abdominal infections (such as complicated appendicitis and peritonitis) and nosocomial pneumonia in both adults and pediatric patients (2 months of age and older). Additionally, it is indicated in adults for the treatment of community-acquired pneumonia, skin and skin structure infections (including cellulitis and abscesses), and female pelvic infections (such as postpartum endometritis or pelvic inflammatory disease).
How PIPERACILLIN AND TAZOBACTAM Works
Piperacillin is a beta-lactam antibiotic that exerts bactericidal activity by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This binding inhibits the third and last stage of bacterial cell wall synthesis, leading to cell lysis. Tazobactam is a beta-lactamase inhibitor that irreversibly binds to and inactivates many plasmid-mediated and chromosomal beta-lactamase enzymes. By neutralizing these enzymes, tazobactam protects piperacillin from degradation, extending its spectrum of activity to include many beta-lactamase-producing bacteria that would otherwise be resistant to piperacillin alone.
Details
- Status
- Prescription
- First Approved
- 2009-09-15
- Routes
- INJECTION, POWDER,FOR SOLUTION
- Dosage Forms
- INJECTABLE, INJECTION
PIPERACILLIN AND TAZOBACTAM Approval History
What PIPERACILLIN AND TAZOBACTAM Treats
12 indicationsPIPERACILLIN AND TAZOBACTAM is approved for 12 conditions since its original approval in 2009. These indications span multiple therapeutic areas including oncology, immunology, and more.
- Intra-Abdominal Infections
- Appendicitis
- Peritonitis
- Nosocomial Pneumonia
- Skin and Skin Structure Infections
- Cellulitis
- Cutaneous Abscess
- Diabetic Foot Infection
- Female Pelvic Infections
- Postpartum Endometritis
- Pelvic Inflammatory Disease
- Community-Acquired Pneumonia
PIPERACILLIN AND TAZOBACTAM Boxed Warning
PHARMACY BULK PACKAGE-NOT FOR DIRECT INFUSION...
PHARMACY BULK PACKAGE-NOT FOR DIRECT INFUSION
PIPERACILLIN AND TAZOBACTAM Competitive Set
ProThree rings of competition based on shared molecular targets and treated indications.
Indication competitors
Same indication, different mechanism — what else might this patient receive?
Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.
Drugs Similar to PIPERACILLIN AND TAZOBACTAM
3 of 20FDA-approved drugs for similar conditions. Compare mechanisms and indications to understand treatment alternatives.
Active Pipeline
Ongoing clinical trials by development phase
Key Completed Trials
Completed studies with published results, ranked by significance
Trial Timeline
Full development history with FDA approval milestones
Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
PIPERACILLIN AND TAZOBACTAM FDA Label Details
Indications & Usage
FDA Label (PDF)Piperacillin and tazobactam for injection, for intravenous use is a combination of piperacillin, a penicillin-class antibacterial and tazobactam, a β-lactamase inhibitor indicated for the treatment of: • Intra-abdominal infections in adult and pediatric patients 2 months of age and older • Nosocomial pneumonia in adult and pediatric patients 2 months of age and older • Skin and skin structure infections in adults • Female pelvic infections in adults • Community-acquired pneumonia in adults To reduce the development of drug-resistant bacteria and maintain the effectiveness of Piperacillin and T...
PHARMACY BULK PACKAGE-NOT FOR DIRECT INFUSION...
Track PIPERACILLIN AND TAZOBACTAM with TheraRadar Pro
Watchlist alerts, full database access, CSV exports across 14,000+ drugs.
Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.