TRIHEXYPHENIDYL HYDROCHLORIDE
Trihexyphenidyl hydrochloride is indicated as an adjunct for the treatment of all forms of parkinsonism, including postencephalitic, arteriosclerotic, and idiopathic types. It is frequently utilized as adjuvant therapy in patients being treated for these conditions with levodopa. Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones.
How TRIHEXYPHENIDYL HYDROCHLORIDE Works
Trihexyphenidyl is a synthetic tertiary amine anticholinergic agent. It exerts its effect by competitively inhibiting muscarinic acetylcholine receptors in the central nervous system and peripheral parasympathetic nervous system. In parkinsonism and drug-induced extrapyramidal symptoms, the drug works primarily by blocking cholinergic transmission in the striatum, thereby helping to restore the functional balance between dopaminergic and cholinergic neurotransmission. It also exhibits a direct inhibitory effect on smooth muscle.
Details
- Status
- Prescription
- First Approved
- 1974-11-26
- Routes
- ORAL
- Dosage Forms
- TABLET, ELIXIR
Companies
TRIHEXYPHENIDYL HYDROCHLORIDE Approval History
What TRIHEXYPHENIDYL HYDROCHLORIDE Treats
1 indicationsTRIHEXYPHENIDYL HYDROCHLORIDE is approved for 1 conditions since its original approval in 1974. These indications span multiple therapeutic areas including oncology, immunology, and more.
- Parkinsonism
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Trial Timeline
Full development history with FDA approval milestones
Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
TRIHEXYPHENIDYL HYDROCHLORIDE FDA Label Details
ProIndications & Usage
FDA Label (PDF)Trihexyphenidyl is indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic). It is often useful as adjuvant therapy when treating these forms of parkinsonism with levodopa. Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones.
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Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.