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Pre-Approval PRO BETASlowing Activity
No new clinical trials started in 1-2 years. Monitor for changes in pipeline strategy. Last trial started: 9/24/2024
Pipeline by Phase
Therapeutic Focus
Clinical Trials (60)
A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy
Started: 9/24/2024
Effect of Sotagliflozin on Cardiovascular Events in Participants With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF Trial)
Started: 6/15/2018
Effect of Sotagliflozin on Cardiovascular and Renal Events in Participants With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk
Started: 12/19/2017
A Study to Evaluate Safety and Effects of Sotagliflozin 400 and 200 mg on Glucose Control in Participants With Type 2 Diabetes, Severe Impairment of Kidney Function and Inadequate Blood Sugar Control
Started: 8/16/2017
Efficacy and Bone Safety of Sotagliflozin 400 and 200 mg Versus Placebo in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control
Started: 2/19/2018
Safety and Efficacy Study of Sotagliflozin on Glucose Control in Participants With Type 2 Diabetes, Moderate Impairment of Kidney Function, and Inadequate Blood Sugar Control
Started: 8/16/2017
Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus Not Currently Treated With Antidiabetic Therapy
Started: 11/11/2016
Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus on Background of Metformin
Started: 11/1/2016
Efficacy and Safety of Sotagliflozin Versus Placebo and Empagliflozin in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking a DPP4 Inhibitor Alone or With Metformin
Started: 11/27/2017
Efficacy and Safety of Sotagliflozin Versus Glimepiride and Placebo in Participants With Type 2 Diabetes Mellitus That Are Taking Metformin Monotherapy
Started: 12/1/2017
Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking Insulin Alone or With Other Oral Antidiabetic Agents
Started: 9/15/2017
Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus on Background of Sulfonylurea Alone or With Metformin
Started: 2/24/2017
Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy
Started: 3/1/2015
A Phase 3 Study to Evaluate the Safety of Sotagliflozin in Patients With Type 1 Diabetes Who Have Inadequate Glycemic Control With Insulin Therapy Alone
Started: 9/1/2015
Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy
Started: 5/1/2015
Telotristat Etiprate - Expanded Treatment for Patients With Carcinoid Syndrome Symptoms
Started: 1/14/2014
TELESTAR (Telotristat Etiprate for Somatostatin Analogue Not Adequately Controlled Carcinoid Syndrome)
Started: 1/8/2013
Telotristat Etiprate for Carcinoid Syndrome Therapy
Started: 3/11/2014
Efficacy and Safety of LX9211 in Participants With Postherpetic Neuralgia
Started: 12/10/2020
A Dose-ranging Study in Patients With Diabetic Peripheral Neuropathic Pain (DPNP)
Started: 11/29/2023
Efficacy, Safety, and PK of LX9211 in Participants With Diabetic Peripheral Neuropathic Pain
Started: 9/3/2020
Safety, Tolerability and Pharmacodynamic Activity of Sotagliflozin in Hemodynamically Stable Participants With Worsening Heart Failure
Started: 12/4/2017
Safety and Efficacy of Sotagliflozin (LX4211) in Patients With Inadequately Controlled Type 1 Diabetes Mellitus
Started: 2/1/2013
Efficacy and Safety of Sotagliflozin in Young Adult Patients With Type 1 Diabetes Mellitus and Elevated Hemoglobin A1C
Started: 4/1/2015
Dose-ranging Study in Patients With Type 1 Diabetes Mellitus
Started: 7/1/2015
A Study to Evaluate Safety and Efficacy of Telotristat Etiprate (LX1606) in Participants With Acute, Mild to Moderate Ulcerative Colitis
Started: 1/30/2012
Study of Telotristat Etiprate (LX1606) in Participants With Symptomatic Carcinoid Syndrome
Started: 6/15/2010
Study of Telotristat Etiprate (LX1606) in Participants With Symptomatic Carcinoid Syndrome Not Managed by Stable-Dose Octreotide Therapy
Started: 3/1/2009
A Multi-Center Trial to Determine the Safety and Efficacy of LX1033 in Subjects With Diarrhea-Predominant Irritable Bowel Syndrome
Started: 2/1/2012
Safety and Efficacy of LX4211 With Metformin in Type 2 Diabetes Patients With Inadequate Glycemic Control on Metformin
Started: 6/1/2011
Study of LX3305 in Subjects With Active Rheumatoid Arthritis on Stable Methotrexate
Started: 7/1/2009
Study of LX4211 in Subjects With Type 2 Diabetes Mellitus
Started: 8/1/2009
Study of LX1031 in Subjects With Non-Constipating Irritable Bowel Syndrome
Started: 12/1/2008
Study of LX6171 in Elderly Volunteers With Age Associated Memory Impairment
Started: 2/1/2008
Study to Evaluate Sotagliflozin in Subjects With Varying Degrees of Renal Function
Started: 12/1/2015
Study to Evaluate the Pharmacokinetics of Telotristat Ethyl in Subjects With Severe Hepatic Impairment
Started: 11/28/2017
A Phase 1 Study to Evaluate the Effects of Omeprazole and Famotidine on the Absorption of Telotristat Ethyl in Healthy Subjects
Started: 9/21/2017
PK Study of Sotagliflozin in Subjects With Hepatic Impairment
Started: 6/1/2015
Phase 1, Open-label, Drug-drug Interaction Study With Octreotide Acetate Injection and Telotristat Etiprate in Healthy Subjects
Started: 7/1/2014
Bioequivalence Study Between 400 mg LX4211 Tablets and 2 X 200 mg LX4211 Tablets
Started: 2/1/2015
Study to Evaluate the Safety, Tolerability, and Efficacy of LX7101 in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension
Started: 3/1/2012
DDI Study With Multiple-dose LX4211 and Single Dose Digoxin
Started: 10/1/2014
DDI Study With Multiple-dose LX4211 and Single Dose Rosuvastatin
Started: 10/1/2014
An Open-Label Drug-Drug Interaction Study of Telotristat Etiprate and Fexofenadine in Healthy Subjects
Started: 7/1/2014
An Open-Label Food Effect Study of Telotristat Etiprate
Started: 6/1/2014
A Open-Label Drug-Drug Interaction Study of Telotristat Etiprate and Midazolam in Healthy Subjects
Started: 5/1/2014
Study to Define the Electrocardiogram Effects of a Single Dose of LX4211 in Healthy Subjects
Started: 7/1/2013
Study to Evaluate the Effect of Single Doses of LX4211 and Canagliflozin on Intestinal Glucose Absorption in Healthy Adult Subjects
Started: 8/1/2013
Study to Determine the Safety, Tolerability and Pharmacokinetics Following Multiple Doses of LX4211 in Healthy Subjects
Started: 8/1/2013
An Open-label Study to Evaluate the Absorption, Metabolism, and Excretion of [14C]-Telotristat Etiprate in Males
Started: 8/1/2013
Study to Evaluate the Pharmacodynamic and Pharmacokinetic Effects of LX4211 in Subjects With Type 2 Diabetes and Renal Impairment
Started: 3/1/2012
Study to Determine the Absorption, Metabolism, and Excretion of [14C]LX4211 in Healthy Male Subjects
Started: 3/1/2013
A Study to Determine the Safety and Efficacy of LX3305 in Subjects With Active Rheumatoid Arthritis
Started: 9/1/2011
An Open-Label Study of Two Formulations of LX1033 in Healthy Human Subjects
Started: 8/1/2011
A Study to Evaluate the Pharmacodynamic Effects of Single-Dose Co-Administration of LX4211 With Januvia® in Type 2 Diabetics
Started: 10/1/2011
A Study to Determine the Pharmacodynamics of LX4211 Relative to Meals in Healthy Subjects
Started: 3/1/2011
A Study to Evaluate the Interaction of LX4211 and Metformin in Healthy Subjects
Started: 2/1/2011
Study of Two Oral Formulations of LX4211 in Patients With Type 2 Diabetes Mellitus
Started: 9/1/2010
Study of LX3305 and Methotrexate in Subjects With Stable Rheumatoid Arthritis
Started: 2/1/2009