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Gastroesophageal Reflux Disease

Gastrointestinal 0 original drugs
0
Novel Drugs
8
Reformulations
0
Active Trials
2
Drug Targets

Gastrointestinal indication. Gastroesophageal Reflux Disease has 0 FDA-approved novel treatments across 2 drug targets. Explore market leaders, treatments by mechanism, the clinical pipeline, and drug targets below.

Phase 3 Readouts Pro

1 active Phase 3 trial with confidence-graded completion dates.

Full calendar →
Q3 2026
Linaprazan glurate 50 mg Twice Daily (BID)
Cinclus Pharma Holding AB
Estimated · aging NCT07037875

Anchored on CT.gov primary completion date. Topline announcements typically precede this by 3–9 months. Confidence labels combine date type (ACTUAL/ESTIMATED) with last-update freshness.

Gastroesophageal Reflux Disease Treatments by Mechanism

Top 2 mechanisms across 18 industry trials with a known mechanism of action.

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Proton Pump Inhibitor
9 trials 1 active 1 sponsor
H+/K+ ATPase
9 trials 6 sponsors

MoA derived from FDA pharmClassEpc when intervention matches an approved drug. Codenamed clinical-stage assets without an approved counterpart show "—" and aren't grouped here — they're still in the phase tables below.

Gastroesophageal Reflux Disease Clinical Pipeline by Phase

97 industry-sponsored trials across 40 sponsors

Novel Gastroesophageal Reflux Disease Drugs by Company (New molecular entities)

No novel drugs found for this indication.

Reformulations (8 drugs) Click to expand

Reformulations are FDA-approved versions of existing molecules in new dosage forms (e.g., oral solution vs tablet, extended-release vs immediate-release). They require a new NDA but use an already-proven active ingredient.

Gastroesophageal Reflux Disease Drug Targets

Molecular targets of approved and investigational Gastroesophageal Reflux Disease drugs — 2 targets tracked.

Generic Drugs (6 ANDA approved) Click to expand

Related Indications

Other Gastrointestinal indications

Drug Categories:

  • Novel Drugs: NDA Type 1/2 (new molecular entity) or original BLA
  • Reformulations: NDA Type 3/5 (new dosage form of existing molecule)
  • Biosimilars: BLA-approved biologics highly similar to reference products
  • Generics: ANDA-approved copies of small molecule drugs

View data sources and methodology