Pain

Pain 2 original drugs

Novel Drugs

Reformulations

Active Trials

Drug Targets

Pain indication. Pain has 2 FDA-approved novel treatments, led by HARROW EYE across 22 drug targets. Explore market leaders, treatments by mechanism, the clinical pipeline, and drug targets below.

Pain Market Leaders

Companies with the most FDA-approved novel Pain drugs.

Phase 3 Readouts Pro

3 active Phase 3 trials with confidence-graded completion dates.

Full calendar →

Q3 2026

PF614 capsule

Ensysce Biosciences

Estimated · fresh NCT06602271

Q4 2026

Combogesic® IV (fixed-dose combination containing acetaminophen 10 mg/ml + ibuprofen 3 mg/ml in 100 ml solution for infusion)

AFT Pharmaceuticals, Ltd.

Estimated · aging NCT07225634

Q4 2026

Combogesic® tablets

AFT Pharmaceuticals, Ltd.

Estimated · aging NCT07225140

Anchored on CT.gov primary completion date. Topline announcements typically precede this by 3–9 months. Confidence labels combine date type (ACTUAL/ESTIMATED) with last-update freshness.

Pain Treatments by Mechanism

Top 12 mechanisms across 50 industry trials with a known mechanism of action.

See full pipeline →

Sodium Channel Blocker

8 trials 3 active 1 sponsor

Nonsteroidal Anti-inflammatory Drug

12 trials 8 sponsors

Opioid Agonist

5 trials 3 sponsors

Partial Opioid Agonist

5 trials 4 sponsors

Mu-opioid receptor

4 trials 4 sponsors

Prostaglandin E1 Analog

4 trials 3 sponsors

Amide Local Anesthetic

3 trials 1 sponsor

Mu-opioid receptor/Norepinephrine transporter/Serotonin transporter

2 trials 2 sponsors

MOR/NET

2 trials 2 sponsors

AXL/FLT-3/KIT/MER/MET/RET/ROS1/TIE-2/TRKB/TYRO3/VEGFR-1/VEGFR-2/VEGFR-3

2 trials 1 sponsor

opioid receptor

2 trials 2 sponsors

Anti-anginal

1 trials 1 sponsor

MoA derived from FDA pharmClassEpc when intervention matches an approved drug. Codenamed clinical-stage assets without an approved counterpart show "—" and aren't grouped here — they're still in the phase tables below.

Pain Clinical Pipeline by Phase

464 industry-sponsored trials across 173 sponsors

Showing 50 of 50 trials

Sponsor	Asset	MoA	Status	Primary Completion	NCT
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	RECRUITING	2027-01-30	NCT07538570
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	COMPLETED	2025-10-27	NCT06887959
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	COMPLETED	2025-10-24	NCT06887972
HALEON	Voltaren Gel	—	COMPLETED	2024-10-29	NCT06379893
EMS	DEC103	—	COMPLETED	2023-12-01	NCT05800392
Bayer	Naproxen Sodium (Aleve, BAY117031)	—	COMPLETED	2020-10-02	NCT04307940
Purdue Pharma, Canada	Methoxyflurane 3mL	—	COMPLETED	2020-03-30	NCT03868436
VistaPharm, Inc.	Oxycodone	Opioid Agonist [EPC]	COMPLETED	2019-08-21	NCT01959204
Cumberland Pharmaceuticals	Ibuprofen	Nonsteroidal Anti-inflammatory Drug [EPC]	COMPLETED	2019-07-02	NCT02583399
Taiwan Mundipharma Pharmaceuticals Ltd.	Oxycodone	Opioid Agonist [EPC]	COMPLETED	2018-12-31	NCT03176199
Taiwan Mundipharma Pharmaceuticals Ltd.	Oxycodone	Opioid Agonist [EPC]	COMPLETED	2018-12-31	NCT03176121
Mundipharma SAS	Methoxyflurane	—	COMPLETED	2018-12-20	NCT03798899
Menarini Group	Tramadol Hydrochloride/Dexketoprofen Trometamol	—	COMPLETED	2017-02-14	NCT02777970
Pacira Pharmaceuticals, Inc	EXPAREL	Amide Local Anesthetic [EPC]	COMPLETED	2017-02-08	NCT02713490
Mallinckrodt	IV Acetaminophen (Treatment A)	—	COMPLETED	2016-06-13	NCT02678416
Mallinckrodt	Oral Acetaminophen	—	COMPLETED	2016-03	NCT02848729
Depomed	diclofenac potassium oral solution	—	COMPLETED	2016-01	NCT02287350
GSK	IODEX® balm	—	COMPLETED	2015-05	NCT02424565
Pacira Pharmaceuticals, Inc	EXPAREL	Amide Local Anesthetic [EPC]	COMPLETED	2015-04	NCT02199574
Pacira Pharmaceuticals, Inc	Bupivacaine SNB	—	COMPLETED	2015-03	NCT02284386
Pacira Pharmaceuticals, Inc	Bupivacaine FNB	—	COMPLETED	2015-03	NCT02255500
Future Sciene Technology	Ibuprofen	Nonsteroidal Anti-inflammatory Drug [EPC]	COMPLETED	2015-02	NCT02327338
Mundipharma Korea Ltd	buprenorphine	Partial Opioid Agonist [EPC]	COMPLETED	2014-11	NCT01983111
Cumberland Pharmaceuticals	IV ibuprofen	—	COMPLETED	2014-08	NCT01901393
Depomed	Zipsor®	—	COMPLETED	2014-05	NCT01982539
Cumberland Pharmaceuticals	Intravenous ibuprofen	—	COMPLETED	2012-12	NCT01334957
Cumberland Pharmaceuticals	Intravenous ibuprofen	—	COMPLETED	2012-09	NCT01334944
Roxane Laboratories	Morphine Sulfate	Mu-opioid receptor	COMPLETED	2012-04	NCT01322360
Takeda	Tinoridine HCl	—	COMPLETED	2011-10	NCT01224756
Nang Kuang Pharmaceutical Co., Ltd.	Carbatin	—	COMPLETED	2011-06	NCT02074267
Nang Kuang Pharmaceutical Co., Ltd.	Smilon®	—	COMPLETED	2010-08	NCT01119924
Boston Scientific Corporation	—	—	COMPLETED	2009-08	NCT00871819
Janssen Korea, Ltd., Korea	Hydromorphone HCl OROS	—	COMPLETED	2009-08	NCT01006356
Johnson & Johnson Taiwan Ltd	Tramadol hydrochloride	Mu-opioid receptor/Norepinephrine transporter/Serotonin transporter	COMPLETED	2009-03	NCT00766675
Pfizer	morphine sulfate extended release capsules	—	COMPLETED	2008-11	NCT00640042
Wyeth is now a wholly owned subsidiary of Pfizer	ibuprofen Formulation 1	—	COMPLETED	2008-11	NCT00740857
Mallinckrodt	XARTEMIS XR	—	TERMINATED	2017-04-26	NCT02508935
GSK	Paracetamol and caffeine	—	TERMINATED	2017-02-06	NCT02974114
Mallinckrodt	IV acetaminophen	—	TERMINATED	2016-05-05	NCT02746263
Pacira Pharmaceuticals, Inc	Intrathecal morphine injection	—	TERMINATED	2015-06	NCT02353754
Pacira Pharmaceuticals, Inc	EXPAREL	Amide Local Anesthetic [EPC]	TERMINATED	2013-12	NCT01919190
Boston Scientific Corporation	—	—	TERMINATED	2013-05	NCT01036529
Orexo AB	SL fentanyl	—	TERMINATED	2011-12-07	NCT01315886
Pfizer	morphine sulfate and naltrexone hydrochloride (EMBEDA)	—	TERMINATED	2011-04	NCT01179191
Janssen Pharmaceutica	Osmotic Release Oral System (OROS) hydromorphone	—	TERMINATED	2010-09	NCT01648699
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.	Celecoxib	Nonsteroidal Anti-inflammatory Drug [EPC]	TERMINATED	2010-01	NCT00894790
Gilead	Ranolazine	Anti-anginal [EPC]	TERMINATED	2009-06	NCT00832572
Johnson & Johnson Taiwan Ltd	Tramadol /acetaminophen	—	TERMINATED	2009-02-17	NCT00766402
ZARS Pharma Inc.	lidocaine 70mg and tetracaine 70mg topical patch	—	SUSPENDED	2013-04	NCT00747669
Janssen Scientific Affairs, LLC	Nucynta ER	MOR/NET	WITHDRAWN	2012-08	NCT01631513

Showing 100 of 162 trials (top 100 by completion date — export for full list)

Sponsor	Asset	MoA	Status	Primary Completion	NCT
Ensysce Biosciences	PF614 capsule	—	RECRUITING	2026-08	NCT06602271
AFT Pharmaceuticals, Ltd.	Combogesic® IV (fixed-dose combination containing acetaminophen 10 mg/ml + ibuprofen 3 mg/ml in 100 ml solution for infusion)	—	NOT YET RECRUITING	2026-10	NCT07225634
AFT Pharmaceuticals, Ltd.	Combogesic® tablets	—	NOT YET RECRUITING	2026-10	NCT07225140
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.	Experimental: YZJ-4729	—	NOT YET RECRUITING	2026-06	NCT06890533
Cessatech A/S	CT001	—	COMPLETED	2025-05-09	NCT06364072
Pharmbio Korea Co., Ltd.	PBK_L1704 0.35mg	—	COMPLETED	2025-02-28	NCT05509868
Viatris Specialty LLC	MR-107A-02	—	COMPLETED	2025-01-31	NCT06215859
Tris Pharma, Inc.	Cebranopadol	—	COMPLETED	2025-01-31	NCT06423703
Tris Pharma, Inc.	Cebranopadol 400 ug	—	COMPLETED	2024-12-30	NCT06545097
Xgene Pharmaceutical Group	XG005 tablet	—	COMPLETED	2024-08-29	NCT06017999
Viatris Specialty LLC	MR-107A-02	—	COMPLETED	2024-08-24	NCT06215820
Eurofarma Laboratorios S.A.	FDC of oxycodone 5 mg/ibuprofen 400 mg	—	COMPLETED	2024-05-28	NCT05081102
Eurofarma Laboratorios S.A.	FDC of codeine 30 mg/dipyrone 500 mg	—	COMPLETED	2024-05-28	NCT04972292
Johnson & Johnson Consumer Inc. (J&JCI)	Acetaminophen/Naproxen Sodium Fixed Combination	—	COMPLETED	2024-05-25	NCT05868122
Johnson & Johnson Consumer Inc. (J&JCI)	Acetaminophen/Naproxen Sodium Fixed Combination	—	COMPLETED	2024-05-17	NCT05761574
Vertex Pharmaceuticals Incorporated	SUZ	—	COMPLETED	2023-12-15	NCT05553366
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	COMPLETED	2023-12-12	NCT05661734
Jiangsu HengRui Medicine Co., Ltd.	SHR8554 Injection	—	COMPLETED	2023-10-19	NCT05375305
Cessatech A/S	CT001	—	COMPLETED	2023-10-05	NCT05508594
Vertex Pharmaceuticals Incorporated	Suzetrigine (SUZ)	—	COMPLETED	2023-08-25	NCT05558410
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Meloxicam Nanocrystal Injection	—	COMPLETED	2023-07-11	NCT06379165
Nobelpharma	NPC-06	—	COMPLETED	2023-05-29	NCT05480553
Unither Pharmaceuticals, France	Paracetamol Uniflash 125mg	—	COMPLETED	2022-11-08	NCT04640376
Vivozon Pharmaceutical Inc.	VVZ-149 Injections	—	COMPLETED	2022-11-03	NCT05764525
Unither Pharmaceuticals, France	Paracetamol 500 Mg Oral Tablet X2	—	COMPLETED	2022-10-12	NCT04622735
Medical Developments International Limited	Methoxyflurane	—	COMPLETED	2022-06-15	NCT03215056
Shijiazhuang Yiling Pharmaceutical Co. Ltd	Felbinac Trometamol Injection	—	COMPLETED	2022-01-19	NCT05297669
Shijiazhuang Yiling Pharmaceutical Co. Ltd	Felbinac Trometamol Injection	—	COMPLETED	2021-12-29	NCT04526132
Neurana Pharmaceuticals, Inc.	Tolperisone Hydrochloride	—	COMPLETED	2021-12-13	NCT04671082
Jiangsu HengRui Medicine Co., Ltd.	SHR8554 Injection	—	COMPLETED	2021-10-19	NCT04766463
Jiangsu HengRui Medicine Co., Ltd.	SHR0410 Injection	—	COMPLETED	2021-06-26	NCT04852003
GSK	Diclofenac diethylamine 2.32% gel	—	COMPLETED	2020-11-12	NCT04052620
Reckitt Benckiser Healthcare (UK) Limited	Ibuprofen 300 mg Oral Tablet	—	COMPLETED	2020-02-20	NCT03785756
Grünenthal GmbH	Tapentadol oral solution 4 mg/mL	—	COMPLETED	2019-03-03	NCT02081391
Lee's Pharmaceutical Limited	Lidocaine (Zingo)	—	COMPLETED	2019-02-28	NCT03653260
Dompé Farmaceutici S.p.A	OKITASK®	—	COMPLETED	2018-07-04	NCT03836807
Mundipharma Research GmbH & Co KG	MR308	—	COMPLETED	2018-06-29	NCT03062644
Charleston Laboratories, Inc	CL-108 5 mg	—	COMPLETED	2018-04-16	NCT03657810
Pfizer	Ibuprofen/Caffeine	—	COMPLETED	2018-04-06	NCT02863575
Grünenthal GmbH	Tramadol/Diclofenac 50/50	—	COMPLETED	2018-03-09	NCT03714672
Mundipharma Pharmaceuticals S.L.	Methoxyflurane	—	COMPLETED	2018-03-06	NCT03256903
Mundipharma Research GmbH & Co KG	MR308	—	COMPLETED	2018-01-04	NCT02982161
Grünenthal GmbH	Tapentadol prolonged release	—	COMPLETED	2017-10-18	NCT02151682
Lachlan Pharma Holdings	Benzocaine Otic Solution	—	COMPLETED	2017-07-21	NCT03116737
Boehringer Ingelheim	Diclofenac	—	COMPLETED	2017-07-13	NCT02700815
Pacira Pharmaceuticals, Inc	bupivacaine liposome injectable suspension	—	COMPLETED	2017-07-07	NCT02713230
Pacira Pharmaceuticals, Inc	bupivacaine liposome injectable suspension	—	COMPLETED	2017-06-30	NCT02713178
Bausch & Lomb Incorporated	Loteprednol Etabonate Ophthalmic Gel dosed TID	—	COMPLETED	2017-06-13	NCT02786901
Trevena Inc.	TRV130	—	COMPLETED	2017-05	NCT02656875
Talphera, Inc	Zalviso™ 15 mcg	—	COMPLETED	2017-04-14	NCT02662764
Pfizer	FDC IBU/APAP 250 mg/500 mg	—	COMPLETED	2017-02-01	NCT02837952
Trevena Inc.	Oliceridine	—	COMPLETED	2016-12	NCT02820324
Trevena Inc.	Oliceridine	—	COMPLETED	2016-12	NCT02815709
Daiichi Sankyo Brasil Farmacêutica LTDA	Transdermal Patch	—	COMPLETED	2016-12	NCT02616068
Boehringer Ingelheim	Loxoprofen sodium	—	COMPLETED	2016-10-19	NCT02831569
Johnson & Johnson	Fulranumab 1 mg	—	COMPLETED	2016-10-10	NCT02289716
Johnson & Johnson	Fulranumab 1 mg	—	COMPLETED	2016-09-19	NCT02301234
Johnson & Johnson	Fulranumab 1 mg	—	COMPLETED	2016-09-16	NCT02336685
Johnson & Johnson	Fulranumab 1 mg	—	COMPLETED	2016-09-15	NCT02336698
INSYS Therapeutics Inc	Buprenorphine	Partial Opioid Agonist [EPC]	COMPLETED	2016-06-24	NCT02634788
Talphera, Inc	sufentanil sublingual 30 mcg tablet	—	COMPLETED	2016-06	NCT02447848
Grünenthal GmbH	Lidocaine 5% medicated plaster	—	COMPLETED	2016-06	NCT01752322
Purdue Pharma LP	Buprenorphine transdermal system	—	COMPLETED	2016-05	NCT01324570
Tris Pharma, Inc.	Cebranopadol	—	COMPLETED	2016-04	NCT02031432
Teva Branded Pharmaceutical Products R&D, Inc.	TV-46763	—	COMPLETED	2016-03-30	NCT02487108
GSK	Paracetamol 1000 mg SR tablets	—	COMPLETED	2016-02	NCT02311881
Jazz Pharmaceuticals	Nabiximols	—	COMPLETED	2016-01-27	NCT01337089
Xigen SA	XG-102	—	COMPLETED	2016-01	NCT02508337
Xigen SA	XG-102	—	COMPLETED	2015-12	NCT02235272
Mundipharma (China) Pharmaceutical Co. Ltd	Oxycodone/Naloxone	—	COMPLETED	2015-08-30	NCT01885182
Mallinckrodt	IV Acetaminophen	—	COMPLETED	2015-08	NCT01635101
Jazz Pharmaceuticals	Nabiximols	—	COMPLETED	2015-07-10	NCT01424566
GW Pharmaceuticals Ltd	Nabiximols	—	COMPLETED	2015-07-02	NCT01262651
Joseph Hazelton	CL-108 (hydrocodone 7.5 mg, acetaminophen 325 mg, promethazine 12.5 mg)	—	COMPLETED	2015-07	NCT02462811
Elite Laboratories, Inc	Oxycodone Naltrexone (a)	—	COMPLETED	2015-07	NCT02401750
Egalet Ltd	SPRIX(intranasal ketorolac tromethamine)	—	COMPLETED	2015-06	NCT02102516
Lumosa Therapeutics Co., Ltd.	Sebacoyl Dinalbuphine Ester	—	COMPLETED	2015-04	NCT02468128
GSK	1% diclofenac sodium plus 3% menthol	—	COMPLETED	2015-03-01	NCT02100670
Bausch & Lomb Incorporated	Loteprednol Etabonate Gel (BID)	—	COMPLETED	2015-03	NCT02208297
Charleston Laboratories, Inc	CL-108	—	COMPLETED	2015-01	NCT02462850
Jazz Pharmaceuticals	Nabiximols	—	COMPLETED	2014-11-24	NCT01361607
Exelixis	cabozantinib	AXL/FLT-3/KIT/MER/MET/RET/ROS1/TIE-2/TRKB/TYRO3/VEGFR-1/VEGFR-2/VEGFR-3	COMPLETED	2014-09	NCT01605227
Purdue Pharma LP	Oxycodone HCl controlled-release tablets	—	COMPLETED	2014-07	NCT01192295
Bausch & Lomb Incorporated	Loteprednol Etabonate Gel (BID)	—	COMPLETED	2014-05	NCT01996839
Menarini Group	Dexketoprofen-single dose	—	COMPLETED	2014-05	NCT01904149
Pfizer	IBU BID	—	COMPLETED	2014-03-29	NCT01794923
American Regent, Inc.	SPRIX	COX-1/COX-2	COMPLETED	2014-03	NCT01819610
Mundipharma Research GmbH & Co KG	oxycodone/naloxone prolonged release (OXN PR) tablets	—	COMPLETED	2014-02	NCT01438567
Menarini Group	Tramadol-single dose	—	COMPLETED	2014-02	NCT01902134
Astellas	Capsaicin 8%	—	COMPLETED	2014-02	NCT01533428
Purdue Pharma LP	Oxycodone hydrochloride controlled-release tablets	—	COMPLETED	2013-12	NCT01369615
Charleston Laboratories, Inc	CL-108 (hydrodocone 7.5 mg, acetaminophen 325 mg, promethazine 12.5 mg)	—	COMPLETED	2013-10	NCT01780428
Vivatech	—	—	COMPLETED	2013-06	NCT02318875
Wex Pharmaceuticals Inc.	Tetrodotoxin	—	COMPLETED	2012-11	NCT00725114
Orion Corporation, Orion Pharma	Ibuprofen	Nonsteroidal Anti-inflammatory Drug [EPC]	COMPLETED	2012-10	NCT01562717
BioDelivery Sciences International	BEMA Buprenorphine	—	COMPLETED	2012-08	NCT01298765
Johnson & Johnson	Oxycodone CR	—	COMPLETED	2012-08	NCT01165281
Orion Corporation, Orion Pharma	Ibuprofen	Nonsteroidal Anti-inflammatory Drug [EPC]	COMPLETED	2012-07	NCT01563289
Medical Developments International Limited	Methoxyflurane	—	COMPLETED	2012-07	NCT01420159
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.	pregabalin	alpha 2 ‑delta subunit of voltage‑gated calcium channels	COMPLETED	2012-03	NCT01202227

Showing 100 of 101 trials (top 100 by completion date — export for full list)

Sponsor	Asset	MoA	Status	Primary Completion	NCT
Eli Lilly	LY4515100	—	RECRUITING	2026-11	NCT07511816
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.	YZJ-4729	—	ACTIVE NOT RECRUITING	2024-07-15	NCT06680466
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.	YZJ-4729	—	NOT YET RECRUITING	2025-10	NCT06901830
Latigo Biotherapeutics	Experimental: LTG-001 High Dose	—	COMPLETED	2026-01-07	NCT07102459
Latigo Biotherapeutics	LTG-001 High Dose	—	COMPLETED	2025-08-08	NCT06774625
Vertex Pharmaceuticals Incorporated	VX-993	—	COMPLETED	2025-05-27	NCT06619847
Levicept	LEVI-04	—	COMPLETED	2024-05-20	NCT05618782
Halia Therapeutics, Inc.	HT-6184	—	COMPLETED	2024-04-30	NCT06241742
Ensysce Biosciences	PF614	—	COMPLETED	2023-11-14	NCT06629402
Laboratorios Liomont	etoricoxib-tramadol	—	COMPLETED	2022-08-18	NCT05995912
Mylan Specialty, LP	MR-107A-02	—	COMPLETED	2022-06-15	NCT05317312
Cymra Life Sciences	Cybis™ 10:25 THC:CBD oil	—	COMPLETED	2022-06-15	NCT04976738
Jiangsu HengRui Medicine Co., Ltd.	HRS4800 tablets	—	COMPLETED	2022-02-28	NCT05318846
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2022-02-17	NCT04977336
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2021-12-05	NCT05034952
Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division	Acetaminophen/naproxen sodium Dose A	—	COMPLETED	2021-04-09	NCT04447040
Jiangsu HengRui Medicine Co., Ltd.	HR18042	—	COMPLETED	2021-01-25	NCT04812860
Mylan Inc.	MR-107A-01	—	COMPLETED	2020-12-15	NCT04571515
Algenis SpA	GTX 2/3	—	COMPLETED	2020-03-19	NCT04799041
Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division	440 mg naproxen sodium with 1000 mg acetaminophen	—	COMPLETED	2019-11-07	NCT03879408
Shijiazhuang Yiling Pharmaceutical Co. Ltd	Felbinac Trometamol Injection	—	COMPLETED	2019-09-30	NCT03872830
Charleston Laboratories, Inc	Arm 1: CL-H1T	—	COMPLETED	2019-08-27	NCT03877718
Concentric Analgesics	CA-008	—	COMPLETED	2019-07-02	NCT03885596
Panag Pharma Inc.	—	—	COMPLETED	2019-06-30	NCT03152578
Neurana Pharmaceuticals, Inc.	Tolperisone	—	COMPLETED	2019-06-28	NCT03802565
Aponia Laboratories, Inc.	S-Ibuprofen	—	COMPLETED	2019-04-04	NCT03852459
Vertex Pharmaceuticals Incorporated	VX-150	—	COMPLETED	2019-01-17	NCT03764072
Mati Therapeutics Inc.	—	—	COMPLETED	2018-12-17	NCT03496467
Propella Therapeutics	CGS-200-1	—	COMPLETED	2018-10-14	NCT03528369
Dr. Reddy's Laboratories Limited	DFN-15 (Celecoxib Oral Solution) 62.5 mg	—	COMPLETED	2018-08-20	NCT03554772
Baudax Bio	DEX-IN	—	COMPLETED	2018-01-18	NCT03348423
Vertex Pharmaceuticals Incorporated	VX-150	—	COMPLETED	2017-12-01	NCT03206749
INSYS Therapeutics Inc	Fentanyl	opioid receptor	COMPLETED	2017-02-10	NCT02915978
A.T. Resolve SARL	RX-10045	—	COMPLETED	2015-09	NCT02329743
Olatec Therapeutics LLC	OLT1177 Gel	—	COMPLETED	2015-08	NCT02104050
Trevena Inc.	TRV130	—	COMPLETED	2015-07	NCT02335294
Aponia Laboratories, Inc.	S-Ibuprofen Topical Gel 5%	—	COMPLETED	2015-07	NCT02324985
McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.	JNJ-10450232 / Not yet marketed	—	COMPLETED	2015-04	NCT02209181
Adwin Life Care	—	—	COMPLETED	2014-11	NCT02380989
Trevena Inc.	TRV130	—	COMPLETED	2014-10	NCT02100748
BioDelivery Sciences International	Buprenorphine	Partial Opioid Agonist [EPC]	COMPLETED	2014-07	NCT01871285
Astellas	ASP3652	—	COMPLETED	2014-03-18	NCT01613586
gicare Pharma Inc.	GIC-1001	—	COMPLETED	2014-03	NCT01926444
Otic Therapy, LLC	Benzocaine	—	COMPLETED	2014-03	NCT02092454
Purdue Pharma LP	V116517 50-mg tablets	—	COMPLETED	2014-03	NCT01688947
Grünenthal GmbH	Tapentadol	—	COMPLETED	2014-02	NCT01729728
Eli Lilly	LY3023703	—	COMPLETED	2013-10	NCT01872910
Cara Therapeutics, Inc.	CR845	—	COMPLETED	2013-08	NCT01789476
Daiichi Sankyo Co., Ltd.	DS-5565	—	COMPLETED	2013-06	NCT01504412
Purdue Pharma LP	V116517 50-mg tablets	—	COMPLETED	2013-06	NCT01688934
IBSA Institut Biochimique SA	Diclofenac sodium	Prostaglandin E1 Analog [EPC]	COMPLETED	2013-05	NCT01706588
Mundipharma Research GmbH & Co KG	Oxycodone naloxone prolonged release tablets	—	COMPLETED	2013-03	NCT01197261
InSightec	—	—	COMPLETED	2013-03	NCT01085565
US Oncology Research	Synera (lidocaine 70mg/tetracaine 70mg)	—	COMPLETED	2013-02	NCT01744197
Talphera, Inc	Sufentanil NanoTab 20 mcg	—	COMPLETED	2013-02	NCT01710345
Pfizer	Ibuprofen/acetaminophen	—	COMPLETED	2012-09-13	NCT01559259
Arbor Pharmaceuticals, Inc.	benzocaine	—	COMPLETED	2012-08	NCT01588535
Grünenthal GmbH	Tapentadol	—	COMPLETED	2012-02	NCT01435577
Tris Pharma, Inc.	GRT6005	—	COMPLETED	2012-01	NCT01347671
Menarini Group	Dexketoprofen Trometamol	—	COMPLETED	2011-10	NCT01307020
NeurogesX	NGX-1998	—	COMPLETED	2011-09	NCT01228838
Hospira, now a wholly owned subsidiary of Pfizer	Dexmedetomidine	—	COMPLETED	2011-08	NCT01378988
Boehringer Ingelheim	Ambroxol Spray	—	COMPLETED	2011-08	NCT01361802
AbbVie (prior sponsor, Abbott)	Hydrocodone/Acetaminophen Extended Release	—	COMPLETED	2011-06	NCT01333722
PainReform LTD	PRF-108	—	COMPLETED	2011-04	NCT00883194
Janssen Pharmaceutical K.K.	Tapentadol	—	COMPLETED	2011-04	NCT01124617
Janssen Pharmaceutical K.K.	Tapentadol Hydrochloride	MOR/NET	COMPLETED	2010-12	NCT01124604
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.	Celecoxib	Nonsteroidal Anti-inflammatory Drug [EPC]	COMPLETED	2010-08	NCT01062113
AbbVie (prior sponsor, Abbott)	Hydrocodone/Acetaminophen Extended Release	—	COMPLETED	2010-05	NCT01038609
Talphera, Inc	Sublingual sufentanil NanoTabs™ and placebo NanoTabs™	—	COMPLETED	2010-03	NCT00833040
Cara Therapeutics, Inc.	CR845	—	COMPLETED	2009-12	NCT00877799
Talphera, Inc	Sublingual Sufentanil/Triazolam NanoTab™ (ARX-F03)	—	COMPLETED	2009-09	NCT00894699
Pfizer	ibuprofen	Nonsteroidal Anti-inflammatory Drug [EPC]	COMPLETED	2009-08-01	NCT00913627
AbbVie (prior sponsor, Abbott)	ABT-712 Extended-release	—	COMPLETED	2009-08	NCT00935311
AstraZeneca	AZD2066	—	COMPLETED	2009-08	NCT00857623
Janssen Pharmaceutical K.K.	Tapentadol PR	—	COMPLETED	2009-07	NCT00805142
Sanofi	ataciguat (HMR1766)	—	COMPLETED	2009-06	NCT00799656
FORSIGHT Vision3	—	—	COMPLETED	2008-10	NCT00741624
AstraZeneca	AZD1386	—	COMPLETED	2008-06	NCT00672646
AstraZeneca	AZD1940	—	COMPLETED	2008-05	NCT00659490
GSK	GSK3858279	—	TERMINATED	2024-10-14	NCT05838755
GSK	GSK3858279	—	TERMINATED	2024-08-12	NCT05838742
Jiangsu HengRui Medicine Co., Ltd.	HR18042 tablets	—	TERMINATED	2022-12-16	NCT05470075
Kowa Research Institute, Inc.	K-285	—	TERMINATED	2021-03-19	NCT04484428
Nobelpharma	NPC-06	—	TERMINATED	2021-02-28	NCT04139330
Regeneron	REGN5069	—	TERMINATED	2020-05-01	NCT03956550
Ono Pharmaceutical Co., Ltd.	ONO-4474	—	TERMINATED	2018-01-09	NCT02997696
Trevena Inc.	TRV130	—	TERMINATED	2015-10-23	NCT02520297
Wex Pharmaceuticals Inc.	Tetrodotoxin	—	TERMINATED	2015-01	NCT01655823
Grünenthal GmbH	Lidocaine 5% medicated plaster	—	TERMINATED	2012-11	NCT01155986
Sanofi	SSR411298	—	TERMINATED	2012-02	NCT01439919
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	Oxycodone CR (standard pain medication)	—	TERMINATED	2011-07-01	NCT01094262
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	JNJ-42160443	—	TERMINATED	2011-07	NCT00964990
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	JNJ-42160443	—	TERMINATED	2011-06-30	NCT00973141
AstraZeneca	AZD1386	—	TERMINATED	2009-07	NCT00878501
AstraZeneca	AZD1386	—	TERMINATED	—	NCT00976534
Sorrento Therapeutics, Inc.	Resiniferatoxin	—	SUSPENDED	2027-06	NCT05067257
EMS	Escócia association	—	WITHDRAWN	2025-02	NCT04666701
EMS	TIRADENTES ASSOCIATION	—	WITHDRAWN	2023-08	NCT04593329
Purdue Pharma LP	HYD tablets	—	WITHDRAWN	2019-07	NCT02542098

Showing 100 of 151 trials (top 100 by completion date — export for full list)

Sponsor	Asset	MoA	Status	Primary Completion	NCT
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	RECRUITING	2026-07-11	NCT07570069
Tafalgie Therapeutics	TT5	—	RECRUITING	2026-10-01	NCT06789861
Sparian Biosciences, Inc	SBS-147	—	RECRUITING	2027-01-31	NCT07335913
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	RECRUITING	2027-02-26	NCT07378865
Shanghai Hengrui Pharmaceutical Co., Ltd.	HRS-6257	—	RECRUITING	2026-05	NCT07301333
iN Therapeutics Co., Ltd.	iN1011-N17 HCl Suspension (Part 1)	—	RECRUITING	2024-07-29	NCT06218784
HALEON	Test Product	—	NOT YET RECRUITING	2026-09	NCT07632274
Iongen Therapeutics Co., Ltd.	IG001119	—	NOT YET RECRUITING	2027-04-30	NCT07618247
Nyree Penn	Diprivan (propofol), Astra-Zeneca	—	NOT YET RECRUITING	2026-05-01	NCT06644573
South Rampart Pharma, LLC	SRP-3D (diethylamide)	—	NOT YET RECRUITING	2025-12-31	NCT05484414
Jiangsu Aosaikang Pharmaceutical Co., Ltd.	5% ASKC200	—	NOT YET RECRUITING	2025-04	NCT06614608
Vertex Pharmaceuticals Incorporated	VX-973	—	COMPLETED	2025-07-21	NCT06615570
Joincare Pharmaceutical Group Industry Co., Ltd	JKN2306	—	COMPLETED	2025-07-02	NCT07412938
Shandong Suncadia Medicine Co., Ltd.	HRS-2129	—	COMPLETED	2025-07-02	NCT06742840
Vertex Pharmaceuticals Incorporated	14C-VX-993	—	COMPLETED	2025-05-17	NCT06886269
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	COMPLETED	2025-04-29	NCT06820307
Vertex Pharmaceuticals Incorporated	SUZ	—	COMPLETED	2025-04-24	NCT06834009
HALEON	Paracetamol ODT	—	COMPLETED	2025-04-17	NCT06855576
HALEON	ADA Liquid Filled Capsules (Test Product)	—	COMPLETED	2025-04-12	NCT06802185
Vertex Pharmaceuticals Incorporated	VX-150	—	COMPLETED	2025-03-22	NCT06420765
Vertex Pharmaceuticals Incorporated	VX-993	—	COMPLETED	2025-02-18	NCT06394167
Shandong Suncadia Medicine Co., Ltd.	HRS-2129	—	COMPLETED	2025-01-20	NCT06619392
Vertex Pharmaceuticals Incorporated	VX-993	—	COMPLETED	2024-12-31	NCT06523595
Vertex Pharmaceuticals Incorporated	VX-993	—	COMPLETED	2024-09-10	NCT06508762
Bayer	Naproxen (BAYH006689)	—	COMPLETED	2024-08-20	NCT06511973
Bayer	Naproxen (BAYH006689)	—	COMPLETED	2024-08-01	NCT06415019
Vertex Pharmaceuticals Incorporated	VX-993	—	COMPLETED	2024-07-02	NCT06392659
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	COMPLETED	2024-06-19	NCT06336096
Vertex Pharmaceuticals Incorporated	VX-993	—	COMPLETED	2024-06-12	NCT06226454
Merck	MK-4318	—	COMPLETED	2024-04-11	NCT06692647
Vertex Pharmaceuticals Incorporated	VX-973	—	COMPLETED	2024-04-04	NCT05866055
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2024-03-30	NCT05704556
Yangtze River Pharmaceutical Group Jiangsu Zilong Pharmaceutical Co. Ltd	Nabufine Hydrochloride Injection	—	COMPLETED	2023-12-26	NCT06902103
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2023-10-30	NCT05851157
iN Therapeutics Co., Ltd.	iN1011-N17	—	COMPLETED	2023-10-08	NCT05496205
Vertex Pharmaceuticals Incorporated	VX-993	—	COMPLETED	2023-09-12	NCT05653323
Sparian Biosciences, Inc	SBS-1000	—	COMPLETED	2023-08-15	NCT05721287
Yangtze River Pharmaceutical Group Co., Ltd.	Meloxicam Nanocrystal Injection(Yangtze River Pharmaceutical Group Co., Ltd.)	—	COMPLETED	2023-07-25	NCT06902090
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2023-07-24	NCT05560464
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2023-06-12	NCT05818852
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2023-06-08	NCT05635110
HALEON	Ibuprofen arginine granules 400 mg	—	COMPLETED	2023-05-15	NCT05737069
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2023-04-16	NCT05541471
Vertex Pharmaceuticals Incorporated	VX-708	—	COMPLETED	2023-04-14	NCT05347394
Tris Pharma, Inc.	Cebranopadol 600 µg	—	COMPLETED	2023-03-30	NCT05491785
HALEON	Advil PM Liqui-Gels Minis	—	COMPLETED	2023-03-21	NCT05674721
Vertex Pharmaceuticals Incorporated	VX-708	—	COMPLETED	2023-03-07	NCT05518734
GSK	GSK3858279	—	COMPLETED	2023-02-10	NCT05174013
Xgene Pharmaceutical Group	XG004	—	COMPLETED	2023-01-23	NCT05454020
Kures, Inc.	KUR-101	—	COMPLETED	2022-10-12	NCT05114265
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2022-09-17	NCT05455502
Vertex Pharmaceuticals Incorporated	VX-150	—	COMPLETED	2022-09-14	NCT05418712
Unither Pharmaceuticals, France	paracetamol Uniflash (125 mg/ 1.25 mL)	—	COMPLETED	2022-07-23	NCT05406752
Atridia Pty Ltd.	HRS4800 tablets	—	COMPLETED	2021-09-20	NCT04573036
HALEON	New Paracetamol Oral Suspension (24 mg/ml)	—	COMPLETED	2021-09-08	NCT05022810
AlzeCure Pharma	ACD440	—	COMPLETED	2021-03-10	NCT04704232
Nanoform Finland Plc	Nanoformed Piroxicam IR Tablet	—	COMPLETED	2021-02-01	NCT05104931
Xgene Pharmaceutical Group	XG005-03	—	COMPLETED	2021-01-28	NCT04283474
Syntrix Biosystems, Inc.	Desmetramadol	—	COMPLETED	2021-01-18	NCT04683926
Addpharma Inc.	AD-2111	—	COMPLETED	2020-07-16	NCT04375865
Xgene Pharmaceutical Group	XG005	—	COMPLETED	2019-12-03	NCT04067947
Centrexion Therapeutics	CNTX-6016	—	COMPLETED	2019-08-21	NCT04154501
GSK	Diclofenac Diethylamine (DDEA) gel	—	COMPLETED	2019-03-01	NCT03497039
Stragen France	STR-324 Dose Level 1	—	COMPLETED	2018-11-07	NCT03430232
Shijiazhuang Yiling Pharmaceutical Co. Ltd	Felbinac Trometamol Injection	—	COMPLETED	2018-11-05	NCT03617510
Atridia Pty Ltd.	0.5μg/kg SHR0410	—	COMPLETED	2018-06-29	NCT03493191
Bayer	Naproxen sodium and diphenhydramine hydrochloride soft capsules	—	COMPLETED	2018-03-26	NCT03396250
Abide Therapeutics	ABX-1431	—	COMPLETED	2018-03	NCT02929264
Xgene Pharmaceutical Group	XG005	—	COMPLETED	2018-01-18	NCT04499209
Syntrix Biosystems, Inc.	Omnitram	—	COMPLETED	2017-12-15	NCT03312777
AstraZeneca	EMLA test patch	—	COMPLETED	2017-11-09	NCT03313336
Liquidia Technologies, Inc.	LIQ865A bupivacaine formulation	—	COMPLETED	2017-03-23	NCT02982889
BDD Pharma Ltd	Radiolabelled Diclofenac Tablet A	—	COMPLETED	2016-05	NCT02714842
Charleston Laboratories, Inc	CL-108	—	COMPLETED	2015-09	NCT02712554
Mundipharma Research Limited	MRXXX	—	COMPLETED	2015-07	NCT02446561
Futura Medical Developments Ltd.	Ibuprofen	Nonsteroidal Anti-inflammatory Drug [EPC]	COMPLETED	2015-05	NCT02666846
Mundipharma Research Limited	BTDS	—	COMPLETED	2015-05	NCT02431624
Boston Scientific Corporation	—	—	COMPLETED	2015-04	NCT01461265
Lumosa Therapeutics Co., Ltd.	Bain®	—	COMPLETED	2015-04	NCT02446301
gicare Pharma Inc.	GIC-1001 375 mg TID	—	COMPLETED	2014-12	NCT02276768
Mundipharma Research Limited	Buprenorphine	Partial Opioid Agonist [EPC]	COMPLETED	2014-12	NCT02268422
GSK	Diclofenac sodium	Prostaglandin E1 Analog [EPC]	COMPLETED	2014-11-21	NCT02201238
Syntrix Biosystems, Inc.	Omnitram	—	COMPLETED	2014-10	NCT02205554
Mundipharma Research Limited	Second generation BTDS patch	—	COMPLETED	2014-08	NCT02160067
GSK	Diclofenac + Menthol Gel	—	COMPLETED	2014-07-15	NCT02192203
GSK	1% Diclofenac Sodium	—	COMPLETED	2014-07-01	NCT02169154
Mundipharma Research Limited	4 mg 12 hourly capsule - strong pain killer fasted	—	COMPLETED	2014-06	NCT02133820
Mundipharma Research Limited	Active comparator MR2XXX	—	COMPLETED	2014-05	NCT02089581
Menarini Group	Enantyum® oral solution	—	COMPLETED	2014-05	NCT02209454
Bayer	Acetylsalicylic acid (Aspirin, BAY1019036)	—	COMPLETED	2014-03	NCT03056703
BDD Pharma Ltd	Radiolabelled T4 Tablet	—	COMPLETED	2014-03	NCT02004301
Trevena Inc.	TRV130 1.5 mg	—	COMPLETED	2013-08	NCT02083315
Aros Pharma ApS	PPC-5650	—	COMPLETED	2013-05	NCT01449487
Pfizer	Ibuprofen 5% topical gel	—	COMPLETED	2013-02	NCT01771822
Pfizer	Topical gel vehicle	—	COMPLETED	2013-02	NCT01787448
Teva Branded Pharmaceutical Products R&D, Inc.	90 mg dose of the hydrocodone bitartrate extended-release tablet administered as either two 45-mg tablets (Treatment A) or one 90-mg tablet (Treatment B).	—	COMPLETED	2013-01	NCT01769677
Teva Branded Pharmaceutical Products R&D, Inc.	a 60 mg dose of the hydrocodone bitartrate extended-release tablet administered as either two 30-mg tablets (Treatment A) or one 60-mg tablet (Treatment B).	—	COMPLETED	2013-01	NCT01758978
Pfizer	PF-04427429	—	COMPLETED	2013-01	NCT01511497
Pfizer	PF-05089771	—	COMPLETED	2012-10	NCT01529671
Pain Therapeutics	Oxycodone	Opioid Agonist [EPC]	COMPLETED	2012-09	NCT01552863

Novel Pain Drugs by Company (New molecular entities)

2 companies have an FDA-approved novel drug for Pain.

HARROW EYE 1 drug

IBSA 1 drug

Reformulations (36 drugs) Click to expand

Reformulations are FDA-approved versions of existing molecules in new dosage forms (e.g., oral solution vs tablet, extended-release vs immediate-release). They require a new NDA but use an already-proven active ingredient.

XIFYRM

AZURITY

UNKNOWN 2025

PHENYLEPHRINE HYDROCHLORIDE IN 0.9% SODIUM CHLORIDE