Mechanisms
Drug landscapes organized by mechanism of action — cross-indication view for BD scouts and biotech investors.
189
Mechanisms
1,534
Approved drugs
1,610
Active Phase 3 trials
0
By drug count + trial activity
Top 60 mechanisms by approved-drug count. Click to see cross-indication landscape, active sponsors, Phase 3 readout calendar.
Corticosteroid
77 drugs 75 active P3
Multiple Myeloma · Relapsed or Refractory Multiple Myeloma
Kinase Inhibitor
51 drugs 102 active P3
Chronic Lymphocytic Leukemia · Breast Cancer
Radiographic Contrast Agent
37 drugs
Nonsteroidal Anti-inflammatory Drug
36 drugs 6 active P3
B-cell Acute Lymphoblastic Leukemia · Lupus Nephritis
Retinoid
36 drugs 1 active P3
Acne Vulgaris
Estrogen
33 drugs
Thiazide Diuretic
28 drugs
Insulin Analog
24 drugs 3 active P3
Pharmacokinetics · Pharmacodynamics
Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor
24 drugs 2 active P3
HIV Infections · Acquired Immune Deficiency Syndrome (AIDS)
Atypical Antipsychotic
23 drugs 4 active P3
Schizophrenia · Bipolar I Disorder
Anti-epileptic Agent
22 drugs 1 active P3
Bipolar Disorder Type I With Mania
Benzodiazepine
20 drugs 3 active P3
Depressive Disorder, Major · Breast Cancer
Azole Antifungal
20 drugs 1 active P3
Candidemia · Candidiasis, Invasive
Radioactive Diagnostic Agent
20 drugs
Progestin
20 drugs
Nucleoside Metabolic Inhibitor
19 drugs 73 active P3
Breast Cancer · Breast Neoplasms
GLP-1 Receptor Agonist
18 drugs 36 active P3
Obesity · Overweight
Alkylating Drug
18 drugs 21 active P3
Glioblastoma · Small Cell Lung Cancer
Prostaglandin Analog
18 drugs 3 active P3
Open Angle Glaucoma · Ocular Hypertension
Angiotensin 2 Receptor Blocker
17 drugs 3 active P3
Immunoglobulin A Nephropathy · Essential Hypertension
Leukocyte Growth Factor
17 drugs 2 active P3
Metastatic Non-small Cell Lung Cancer
RANK Ligand Inhibitor
17 drugs 1 active P3
Giant Cell Tumor of Bone
Osmotic Diuretic
16 drugs
Nitroimidazole Antimicrobial
15 drugs 1 active P3
Intra-abdominal Infections
Vascular Endothelial Growth Factor Inhibitor
13 drugs 66 active P3
Ovarian Cancer · Hepatocellular Carcinoma
Central Nervous System Stimulant
13 drugs 4 active P3
B-cell Acute Lymphoblastic Leukemia · Lupus Nephritis
Aromatic Amino Acid Decarboxylation Inhibitor
13 drugs
Aromatic Amino Acid
13 drugs
Endoglycosidase
12 drugs 198 active P3
Non-small Cell Lung Cancer · Chronic Lymphocytic Leukemia
Tumor Necrosis Factor Blocker
12 drugs 4 active P3
Psoriasis · Moderate Chronic Plaque Psoriasis
Mood Stabilizer
12 drugs 1 active P3
Bipolar Disorder Type I With Mania
Calcineurin Inhibitor Immunosuppressant
12 drugs 1 active P3
Primary Membranous Nephropathy
Programmed Death Receptor-1 Blocking Antibody
11 drugs 176 active P3
Non-Small Cell Lung Cancer · Non-small Cell Lung Cancer
CD20-directed Cytolytic Antibody
11 drugs 72 active P3
Chronic Lymphocytic Leukemia · Small Lymphocytic Lymphoma
Aminoglycoside Antibacterial
11 drugs 47 active P3
Multiple Myeloma · Relapsed or Refractory Multiple Myeloma
Interleukin-23 Antagonist
11 drugs 18 active P3
Colitis, Ulcerative · Crohn Disease
Dipeptidyl Peptidase 4 Inhibitor
11 drugs 9 active P3
Heart Failure · Diabetes Mellitus, Type 2
Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
11 drugs 1 active P3
HIV · HIV Infections
Nitrate Vasodilator
11 drugs
alpha-Adrenergic Agonist
11 drugs
beta-Adrenergic Agonist
11 drugs
Catecholamine
11 drugs
HER2/neu Receptor Antagonist
10 drugs 29 active P3
HER2-positive Breast Cancer · Breast Cancer
Sodium-Glucose Cotransporter 2 Inhibitor
10 drugs 13 active P3
Heart Failure · Diabetes Mellitus, Type 2
General Anesthetic
10 drugs 1 active P3
General Anesthetic
Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
10 drugs
Cytochrome P450 3A Inhibitor
9 drugs 2 active P3
Acquired Immune Deficiency Syndrome (AIDS) · HIV Infections
Antiarrhythmic
9 drugs
mTOR Inhibitor Immunosuppressant
8 drugs 11 active P3
Carcinoma, Renal Cell · Neuroendocrine Tumors
Complement Inhibitor
8 drugs 6 active P3
Paroxysmal Nocturnal Hemoglobinuria · C3G
Phosphodiesterase 5 Inhibitor
8 drugs 2 active P3
Hypertension, Pulmonary · Erectile Dysfunction
Acetylcholine Release Inhibitor
8 drugs 2 active P3
Chronic Migraine · Episodic Migraine
Osmotic Laxative
8 drugs 1 active P3
Candidal Vulvovaginitis (ICD-10 Code: B37.3) · Vulvovaginal Candidiasis (VVC)
Sulfonylurea
8 drugs
Thiazide-like Diuretic
8 drugs
Platelet Aggregation Inhibitor
8 drugs
Loop Diuretic
8 drugs
Androgen Receptor Inhibitor
7 drugs 20 active P3
Metastatic Castration-resistant Prostate Cancer · Prostatic Neoplasms
Phosphodiesterase 4 Inhibitor
7 drugs 7 active P3
Plaque Psoriasis · Active Juvenile Psoriatic Arthritis
Interleukin-12 Antagonist
7 drugs 7 active P3
Plaque Psoriasis · Crohn Disease
+129 more mechanisms with 3+ approved drugs (long-tail not yet built into pages).
Methodology
Mechanisms are sourced from FDA pharmClassEpc (Established Pharmacologic Class) labeling on every approved drug. Drug count is approved drugs only; trial counts are active industry-sponsored trials matched to those approved drugs by intervention name.
Pages are built for mechanisms with 3+ approved drugs to avoid thin pages on rare or single-drug classes. As more drugs in a long-tail class are approved, those pages auto-build.