5-HT 1D receptor Inhibitors
2 drugsAbout 5-HT 1D receptor
The 5-HT<sub>1D</sub> receptor is a serotonin receptor subtype in the central nervous system (CNS) that modulates neuronal activity and neurotransmitter release. As a G protein-coupled receptor (GPCR), it binds serotonin (5-hydroxytryptamine).
The 5-HT<sub>1D</sub> receptor is a therapeutic target for CNS disorders, but there is currently no genetic evidence linking it to specific diseases.
Two FDA-approved drugs, SYMBRAVO and MAXALT, target the 5-HT<sub>1D</sub> receptor. Both drugs are small molecules and address CNS indications.
Strategic Insights
ℹ️ How we calculate- White space opportunity in Endometrial Cancer with only 1 trials.
- phase2 represents biological uncertainty with 0% completion.
Top 5-HT 1D receptor Drugs
The competitive landscape includes AXSOME and Merck, each with one approved drug.
The market is not highly concentrated, suggesting opportunities for new entrants with differentiated products.
5-HT 1D receptor Drug Modality Landscape
Modalities
Routes of Administration
5-HT 1D receptor is amenable to small molecule drugs, with oral options available for convenient dosing.
Explore alternative modalities like antibodies or peptides to differentiate from existing therapies.
5-HT 1D receptor Clinical Trials 46 trials
Completion by Phase
| Phase | Total | Completed | Failed | Active | Completion |
|---|---|---|---|---|---|
| Phase 1 | 5 | 5 | 0 | 0 | 100% |
| Phase 2 | 9 | 5 | 2 | 2 | 71% |
| Phase 3 | 21 | 18 | 3 | 0 | 86% |
| Phase 4 | 11 | 4 | 3 | 4 | 57% |
Top Sponsors
By Modality
5-HT 1D receptor Drug Approval Timeline (1998 - 2025)
The first drug was approved in 1998, and the most recent in 2025, spanning 28 years.
The recent approval suggests renewed interest, but consider potential market saturation.
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Deep insights for drug target analysis
Competitive Landscape
- • 2 companies competing
- • Market share by company
Full Drug Portfolio
- • All 2 approved drugs
- • Approval dates & indications
Genetic Validation
- • Full genetic evidence table
- • Effect sizes & directions
Approval Timeline
- • Full 2-drug timeline
- • First-of-modality markers
Clinical Trials Analysis
- • Competition: High (15 sponsors)
- • White space: 10 underexplored indications
- • Success rates by condition
Full summary • All drugs • Genetic evidence • Trials • Timeline
How We Calculate These Metrics
Target Attractiveness Score
A 0-100 score based on trial activity, sponsor diversity, and completion rates. Calculated from 35 clinical trials targeting 5-HT 1D receptor.
Completion rate: Percentage of trials that reached their planned endpoint. Trials terminated early, withdrawn, or suspended are not counted—these often indicate safety issues, lack of efficacy, or strategic pivots.
- Highly Attractive (80+): High trial activity, many sponsors, strong completion rates
- Attractive (60-79): Good trial activity and validation
- Moderate (40-59): Moderate interest from sponsors
- Low (under 40): Limited trial activity or validation concerns
Strategic Insights
Auto-generated insights based on trial analytics including competition intensity, white space opportunities, modality shifts, and failure patterns. We analyze trial sponsors, phases, indications, and outcomes.
Risk Signals
- High Competition: Many sponsors competing for this target (may reduce market opportunity)
- High Failure Risk: Low trial completion rates suggest development challenges
- Low Validation: Limited trial activity or poor outcomes indicate uncertain viability
- White Space Available: Underexplored indications present opportunities