M2 muscarinic receptor Inhibitors
1 drugsAbout M2 muscarinic receptor
The M2 muscarinic receptor is a G protein-coupled receptor primarily located in the heart and smooth muscle. It mediates the slowing of heart rate and plays a role in cholinergic neurotransmission. As a subtype of the muscarinic acetylcholine receptor family, it is involved in various physiological processes.
Currently, there is no genetic evidence directly linking the M2 muscarinic receptor to specific diseases. However, its role in cholinergic neurotransmission makes it a potential target for drug development. Modulating M2 receptor activity has therapeutic potential in several areas.
There is one FDA-approved drug, darifenacin, that targets muscarinic receptors, approved in 2017. It is a small molecule drug developed by Macleods Pharms Ltd. and is categorized within the 'Other' therapeutic area.
Strategic Insights
ℹ️ How we calculate- White space opportunity in Untreated Follicular Lymphoma with only 1 trials.
Top M2 muscarinic receptor Drugs
Macleods Pharms Ltd. is the only company with an approved drug targeting M2.
The low number of competitors suggests a potential opportunity, but also a high barrier to entry.
M2 muscarinic receptor Drug Modality Landscape
Modalities
Routes of Administration
Only one approved drug targets M2 muscarinic receptor, using small molecule modality.
Explore opportunities for novel modalities like antibodies or biologics to differentiate from existing treatments.
M2 muscarinic receptor Clinical Trials 8 trials
Completion by Phase
| Phase | Total | Completed | Failed | Active | Completion |
|---|---|---|---|---|---|
| Phase 1 | 2 | 2 | 0 | 0 | 100% |
| Phase 2 | 2 | 0 | 1 | 1 | 0% |
| Phase 3 | 1 | 1 | 0 | 0 | 100% |
| Phase 4 | 3 | 2 | 1 | 0 | 67% |
Top Sponsors
By Modality
Top Conditions
Top Drugs
M2 muscarinic receptor Drug Approval Timeline (2017 - 2017)
The first and most recent drug approval was in 2017, with darifenacin.
The lack of recent approvals indicates a potentially saturated market or challenges in developing new M2-targeting drugs.
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Deep insights for drug target analysis
Competitive Landscape
- • 1 companies competing
- • Market share by company
Full Drug Portfolio
- • All 1 approved drugs
- • Approval dates & indications
Genetic Validation
- • Full genetic evidence table
- • Effect sizes & directions
Approval Timeline
- • Full 1-drug timeline
- • First-of-modality markers
Clinical Trials Analysis
- • Competition: High (15 sponsors)
- • White space: 10 underexplored indications
- • Success rates by condition
Full summary • All drugs • Genetic evidence • Trials • Timeline
How We Calculate These Metrics
Target Attractiveness Score
A 0-100 score based on trial activity, sponsor diversity, and completion rates. Calculated from 19 clinical trials targeting M2 muscarinic receptor.
Completion rate: Percentage of trials that reached their planned endpoint. Trials terminated early, withdrawn, or suspended are not counted—these often indicate safety issues, lack of efficacy, or strategic pivots.
- Highly Attractive (80+): High trial activity, many sponsors, strong completion rates
- Attractive (60-79): Good trial activity and validation
- Moderate (40-59): Moderate interest from sponsors
- Low (under 40): Limited trial activity or validation concerns
Strategic Insights
Auto-generated insights based on trial analytics including competition intensity, white space opportunities, modality shifts, and failure patterns. We analyze trial sponsors, phases, indications, and outcomes.
Risk Signals
- High Competition: Many sponsors competing for this target (may reduce market opportunity)
- High Failure Risk: Low trial completion rates suggest development challenges
- Low Validation: Limited trial activity or poor outcomes indicate uncertain viability
- White Space Available: Underexplored indications present opportunities