TheraRadar
Class patent landscape

Vascular Endothelial Growth Factor Inhibitor

Cross-drug patent estate across 3 approved drugs in the vascular endothelial growth factor inhibitor class. Loss-of-exclusivity timeline, sponsor concentration, and per-drug links to full patent landscapes.

Approved drugs
3
with patent data
OB patents
97
across the class
Patent families
40
1,901 docs · 46 countries
Earliest US LOE
Jul 30, 2035
first drug off patent
Latest US LOE
May 9, 2042
last drug off patent

Loss-of-exclusivity waterfall

Drugs in the vascular endothelial growth factor inhibitor class sorted by US Orange Book expiry — earliest LOE first. Each row links to the drug's full patent landscape.

Drug Sponsor OB patents Families Intl docs Latest US expiry
AVASTIN
bevacizumab
Genentech, Inc. 6 6 263 Jul 30, 2035
+9y
View →
LUCENTIS
ranibizumab
Genentech, Inc. 3 3 99 Nov 4, 2035
+9y
View →
EYLEA
aflibercept
Regeneron Pharmaceuticals, Inc. 88 34 1,539 May 9, 2042
+16y
View →

Sponsor concentration

Which companies anchor the IP across this class.

Pro Sponsor concentration — Which sponsors anchor the IP across the class
See what Pro includes ↓

Methodology & data sources

  • Drugs in class: aggregated from drug.pharmClassEpc field. Drugs without EPC tags are not included here (data gap, not coverage limitation).
  • Patent data: per-drug patent thickets from FDA Orange Book / Purple Book + BigQuery family expansion. See individual drug patent pages for source detail.
  • LOE waterfall: sorted by latestPatentExpiry from Orange Book. Reflects US patent term adjustments (PTA) but not exclusivity overlays (ODE, NPP, PED).
  • Class-level analysis: sums across per-drug thickets. Same patent family may appear in multiple drugs (e.g., Jakafi + Opzelura share composition family) — counted once per family per drug for OB totals.
Intelligence, not legal advice. Class-level summary reflects what's listed publicly. Generic launch dynamics depend on per-drug NCE/ODE/PED overlays, ANDA Para IV outcomes, and BPCIA settlements not captured here.

TheraRadar Pro — patent intelligence

Free covers what's publicly listed: Orange Book patents, basic stats, composition expiry. Pro adds the deeper view: LLM-driven estate analysis, full international family thicket, and (coming soon) alerts + exports.

Always free

  • Orange Book patent table (every patent, family, use code, expiry)
  • Stat strip — OB count, families, global doc footprint, multiplier
  • Composition family priority + nominal global expiry
  • International vs US expiry comparison
  • Coverage status + methodology
  • LOE waterfall across all approved drugs in the class
PRO

What Pro adds today

  • Estate analysis (sections 2-5) — Composition anchor, lifecycle layers, international vs US, strategic outlook
  • Full patent families table — Country lists, doc counts, priority dates per family
  • Sponsor concentration — Who owns the IP across the class
  • International nominal expiries — Priority + 20 years per family with global vs US gap
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Class patent data updated: Jun 17, 2026